A Novel Targeted RIG-I Receptor 5′Triphosphate Double Strain RNA-Based Adjuvant Significantly Improves the Immunogenicity of the SARS-CoV-2 Delta-Omicron Chimeric RBD-Dimer Recombinant Protein Vaccine

A Novel Targeted RIG-I Receptor 5′Triphosphate Double Strain RNA-Based Adjuvant Significantly Improves the Immunogenicity of the SARS-CoV-2 Delta-Omicron Chimeric RBD-Dimer Recombinant Protein Vaccine

The rapid mutation and spread of SARS-CoV-2 variants recently, especially through the emerging variants Omicron BA5, BF7, XBB and BQ1, necessitate the development of universal vaccines to provide broad spectrum protection against variants. For the SARS-CoV-2 universal recombinant protein vaccines, a...

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Bibliographic Details
Main Authors: Yu Bai, Chaoqiang An, Xuanxuan Zhang, Kelei Li, Feiran Cheng, Bopei Cui, Ziyang Song, Dong Liu, Jialu Zhang, Qian He, Jianyang Liu, Qunying Mao, Zhenglun Liang
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Viruses
Subjects:
retinoic acid-inducible gene-I (RIG-I) receptor
vaccine adjuvant
immunogenicity
recombinant protein vaccine
Online Access:https://www.mdpi.com/1999-4915/15/5/1099

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