Mitochondrial Dynamics in Drug-Induced Liver Injury
Mitochondria have been studied for decades from the standpoint of metabolism and ATP generation. However, in recent years mitochondrial dynamics and its influence on bioenergetics and cellular homeostasis is also being appreciated. Mitochondria undergo regular cycles of fusion and fission regulated...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
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| Series: | Livers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2673-4389/1/3/10 |
| _version_ | 1797514135530897408 |
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| author | Anup Ramachandran David S. Umbaugh Hartmut Jaeschke |
| author_facet | Anup Ramachandran David S. Umbaugh Hartmut Jaeschke |
| author_sort | Anup Ramachandran |
| collection | DOAJ |
| description | Mitochondria have been studied for decades from the standpoint of metabolism and ATP generation. However, in recent years mitochondrial dynamics and its influence on bioenergetics and cellular homeostasis is also being appreciated. Mitochondria undergo regular cycles of fusion and fission regulated by various cues including cellular energy requirements and pathophysiological stimuli, and the network of critical proteins and membrane lipids involved in mitochondrial dynamics is being revealed. Hepatocytes are highly metabolic cells which have abundant mitochondria suggesting a biologically relevant role for mitochondrial dynamics in hepatocyte injury and recovery. Here we review information on molecular mediators of mitochondrial dynamics and their alteration in drug-induced liver injury. Based on current information, it is evident that changes in mitochondrial fusion and fission are hallmarks of liver pathophysiology ranging from acetaminophen-induced or cholestatic liver injury to chronic liver diseases. These alterations in mitochondrial dynamics influence multiple related mitochondrial responses such as mitophagy and mitochondrial biogenesis, which are important adaptive responses facilitating liver recovery in several contexts, including drug-induced liver injury. The current focus on characterization of molecular mechanisms of mitochondrial dynamics is of immense relevance to liver pathophysiology and have the potential to provide significant insight into mechanisms of liver recovery and regeneration after injury. |
| first_indexed | 2024-03-10T06:27:21Z |
| format | Article |
| id | doaj.art-d3645c0a37d44468ab54a8a24bfe5a94 |
| institution | Directory Open Access Journal |
| issn | 2673-4389 |
| language | English |
| last_indexed | 2024-03-10T06:27:21Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Livers |
| spelling | doaj.art-d3645c0a37d44468ab54a8a24bfe5a942023-11-22T18:53:46ZengMDPI AGLivers2673-43892021-06-011310211510.3390/livers1030010Mitochondrial Dynamics in Drug-Induced Liver InjuryAnup Ramachandran0David S. Umbaugh1Hartmut Jaeschke2Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USADepartment of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USAMitochondria have been studied for decades from the standpoint of metabolism and ATP generation. However, in recent years mitochondrial dynamics and its influence on bioenergetics and cellular homeostasis is also being appreciated. Mitochondria undergo regular cycles of fusion and fission regulated by various cues including cellular energy requirements and pathophysiological stimuli, and the network of critical proteins and membrane lipids involved in mitochondrial dynamics is being revealed. Hepatocytes are highly metabolic cells which have abundant mitochondria suggesting a biologically relevant role for mitochondrial dynamics in hepatocyte injury and recovery. Here we review information on molecular mediators of mitochondrial dynamics and their alteration in drug-induced liver injury. Based on current information, it is evident that changes in mitochondrial fusion and fission are hallmarks of liver pathophysiology ranging from acetaminophen-induced or cholestatic liver injury to chronic liver diseases. These alterations in mitochondrial dynamics influence multiple related mitochondrial responses such as mitophagy and mitochondrial biogenesis, which are important adaptive responses facilitating liver recovery in several contexts, including drug-induced liver injury. The current focus on characterization of molecular mechanisms of mitochondrial dynamics is of immense relevance to liver pathophysiology and have the potential to provide significant insight into mechanisms of liver recovery and regeneration after injury.https://www.mdpi.com/2673-4389/1/3/10drug-induced liver injuryacetaminophenmitochondrial dynamicsfusionfission |
| spellingShingle | Anup Ramachandran David S. Umbaugh Hartmut Jaeschke Mitochondrial Dynamics in Drug-Induced Liver Injury Livers drug-induced liver injury acetaminophen mitochondrial dynamics fusion fission |
| title | Mitochondrial Dynamics in Drug-Induced Liver Injury |
| title_full | Mitochondrial Dynamics in Drug-Induced Liver Injury |
| title_fullStr | Mitochondrial Dynamics in Drug-Induced Liver Injury |
| title_full_unstemmed | Mitochondrial Dynamics in Drug-Induced Liver Injury |
| title_short | Mitochondrial Dynamics in Drug-Induced Liver Injury |
| title_sort | mitochondrial dynamics in drug induced liver injury |
| topic | drug-induced liver injury acetaminophen mitochondrial dynamics fusion fission |
| url | https://www.mdpi.com/2673-4389/1/3/10 |
| work_keys_str_mv | AT anupramachandran mitochondrialdynamicsindruginducedliverinjury AT davidsumbaugh mitochondrialdynamicsindruginducedliverinjury AT hartmutjaeschke mitochondrialdynamicsindruginducedliverinjury |