Untargeted Metabolomic Profiling Reveals Differentially Expressed Serum Metabolites and Pathways in Type 2 Diabetes Patients with and without Cognitive Decline: A Cross-Sectional Study

Untargeted Metabolomic Profiling Reveals Differentially Expressed Serum Metabolites and Pathways in Type 2 Diabetes Patients with and without Cognitive Decline: A Cross-Sectional Study

Diabetes is recognized as a risk factor for cognitive decline, but the underlying mechanisms remain elusive. We aimed to identify the metabolic pathways altered in diabetes-associated cognitive decline (DACD) using untargeted metabolomics. We conducted liquid chromatography–mass spectrometry-based u...

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Bibliographic Details
Main Authors: Neyla S. Al-Akl, Olfa Khalifa, Georgios Ponirakis, Aijaz Parray, Marwan Ramadan, Shafi Khan, Mani Chandran, Raheem Ayadathil, Ahmed Elsotouhy, Ahmed Own, Hanadi Al Hamad, Julie Decock, Nehad M. Alajez, Omar Albagha, Rayaz A. Malik, Omar M. A. El-Agnaf, Abdelilah Arredouani
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
dementia
mild cognitive impairment
type 2 diabetes
metabolomics
diabetes-associated cognitive decline
Online Access:https://www.mdpi.com/1422-0067/25/4/2247

Internet

https://www.mdpi.com/1422-0067/25/4/2247

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