The lung-gut crosstalk in respiratory and inflammatory bowel disease
Both lung and gut belong to the common mucosal immune system (CMIS), with huge surface areas exposed to the external environment. They are the main defense organs against the invasion of pathogens and play a key role in innate and adaptive immunity. Recently, more and more evidence showed that stimu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1218565/full |
| _version_ | 1797738284396314624 |
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| author | Baoxiang Du Yan Fu Yuxiu Han Qihui Sun Jinke Xu Yong Yang Yong Yang Rong Rong Rong Rong Rong Rong |
| author_facet | Baoxiang Du Yan Fu Yuxiu Han Qihui Sun Jinke Xu Yong Yang Yong Yang Rong Rong Rong Rong Rong Rong |
| author_sort | Baoxiang Du |
| collection | DOAJ |
| description | Both lung and gut belong to the common mucosal immune system (CMIS), with huge surface areas exposed to the external environment. They are the main defense organs against the invasion of pathogens and play a key role in innate and adaptive immunity. Recently, more and more evidence showed that stimulation of one organ can affect the other, as exemplified by intestinal complications during respiratory disease and vice versa, which is called lung-gut crosstalk. Intestinal microbiota plays an important role in respiratory and intestinal diseases. It is known that intestinal microbial imbalance is related to inflammatory bowel disease (IBD), this imbalance could impact the integrity of the intestinal epithelial barrier and leads to the persistence of inflammation, however, gut microbial disturbances have also been observed in respiratory diseases such as asthma, allergy, chronic obstructive pulmonary disease (COPD), and respiratory infection. It is not fully clarified how these disorders happened. In this review, we summarized the latest examples and possible mechanisms of lung-gut crosstalk in respiratory disease and IBD and discussed the strategy of shaping intestinal flora to treat respiratory diseases. |
| first_indexed | 2024-03-12T13:40:38Z |
| format | Article |
| id | doaj.art-d36672ede6524760af9701b934ea001e |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-12T13:40:38Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-d36672ede6524760af9701b934ea001e2023-08-23T19:31:18ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-08-011310.3389/fcimb.2023.12185651218565The lung-gut crosstalk in respiratory and inflammatory bowel diseaseBaoxiang Du0Yan Fu1Yuxiu Han2Qihui Sun3Jinke Xu4Yong Yang5Yong Yang6Rong Rong7Rong Rong8Rong Rong9College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong Center for Disease Control and Prevention, Jinan, ChinaShandong Antiviral Engineering Research Center of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan, ChinaCollege of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan, ChinaShandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research, Shandong University of Traditional Chinese Medicine, Jinan, ChinaBoth lung and gut belong to the common mucosal immune system (CMIS), with huge surface areas exposed to the external environment. They are the main defense organs against the invasion of pathogens and play a key role in innate and adaptive immunity. Recently, more and more evidence showed that stimulation of one organ can affect the other, as exemplified by intestinal complications during respiratory disease and vice versa, which is called lung-gut crosstalk. Intestinal microbiota plays an important role in respiratory and intestinal diseases. It is known that intestinal microbial imbalance is related to inflammatory bowel disease (IBD), this imbalance could impact the integrity of the intestinal epithelial barrier and leads to the persistence of inflammation, however, gut microbial disturbances have also been observed in respiratory diseases such as asthma, allergy, chronic obstructive pulmonary disease (COPD), and respiratory infection. It is not fully clarified how these disorders happened. In this review, we summarized the latest examples and possible mechanisms of lung-gut crosstalk in respiratory disease and IBD and discussed the strategy of shaping intestinal flora to treat respiratory diseases.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1218565/fulllung-gut crosstalkcommon mucosal immune systemrespiratory diseaseinflammatory bowel diseasemicrobiota |
| spellingShingle | Baoxiang Du Yan Fu Yuxiu Han Qihui Sun Jinke Xu Yong Yang Yong Yang Rong Rong Rong Rong Rong Rong The lung-gut crosstalk in respiratory and inflammatory bowel disease Frontiers in Cellular and Infection Microbiology lung-gut crosstalk common mucosal immune system respiratory disease inflammatory bowel disease microbiota |
| title | The lung-gut crosstalk in respiratory and inflammatory bowel disease |
| title_full | The lung-gut crosstalk in respiratory and inflammatory bowel disease |
| title_fullStr | The lung-gut crosstalk in respiratory and inflammatory bowel disease |
| title_full_unstemmed | The lung-gut crosstalk in respiratory and inflammatory bowel disease |
| title_short | The lung-gut crosstalk in respiratory and inflammatory bowel disease |
| title_sort | lung gut crosstalk in respiratory and inflammatory bowel disease |
| topic | lung-gut crosstalk common mucosal immune system respiratory disease inflammatory bowel disease microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1218565/full |
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