Activity of Chitosans in combination with antibiotics in Pseudomonas aeruginosa
<p>Chitosan and its derivative water soluble Chitosan oligosaccharide are used in a variety of applications in pharmaceutical preparations. In this study, 2 wild (ATCC 15729 and PAO1) and 2 mutant strains (PT121 and PT149) of <i>P. aeruginosa </i>are investigated for drug-drug inte...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2009-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v05p0153.htm |
| _version_ | 1829460540808757248 |
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| author | San Tin, Kishore R. Sakharkar, Chu Sing Lim, Meena K. Sakharkar |
| author_facet | San Tin, Kishore R. Sakharkar, Chu Sing Lim, Meena K. Sakharkar |
| author_sort | San Tin, Kishore R. Sakharkar, Chu Sing Lim, Meena K. Sakharkar |
| collection | DOAJ |
| description | <p>Chitosan and its derivative water soluble Chitosan oligosaccharide are used in a variety of applications in pharmaceutical preparations. In this study, 2 wild (ATCC 15729 and PAO1) and 2 mutant strains (PT121 and PT149) of <i>P. aeruginosa </i>are investigated for drug-drug interactions <i>in vitro</i>. 10 antimicrobial agents (antibiotics) are combined with different degree of deacetylated Chitosans and Chitosan oligosaccharide. All the chitosans show synergistic activity with sulfamethoxazole, a sulfonamide antimicrobial agent. It is interesting to observe that the MIC value for the MexEF-OprN overexpressing mutant strain of <i>P. aeruginosa</i> is 5 fold higher than the other strains under investigation suggesting a possible role of this efflux pump in Sulfamethoxazole efflux. The findings suggest on the use of chitosans as enhancing agent in combination with antibiotics in pharmaceutical preparations.</p> |
| first_indexed | 2024-12-12T11:34:56Z |
| format | Article |
| id | doaj.art-d36706f8792a41a2b188a4ef0af00ed8 |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-12-12T11:34:56Z |
| publishDate | 2009-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-d36706f8792a41a2b188a4ef0af00ed82022-12-22T00:25:42ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882009-01-0152153160Activity of Chitosans in combination with antibiotics in Pseudomonas aeruginosaSan Tin, Kishore R. Sakharkar, Chu Sing Lim, Meena K. Sakharkar<p>Chitosan and its derivative water soluble Chitosan oligosaccharide are used in a variety of applications in pharmaceutical preparations. In this study, 2 wild (ATCC 15729 and PAO1) and 2 mutant strains (PT121 and PT149) of <i>P. aeruginosa </i>are investigated for drug-drug interactions <i>in vitro</i>. 10 antimicrobial agents (antibiotics) are combined with different degree of deacetylated Chitosans and Chitosan oligosaccharide. All the chitosans show synergistic activity with sulfamethoxazole, a sulfonamide antimicrobial agent. It is interesting to observe that the MIC value for the MexEF-OprN overexpressing mutant strain of <i>P. aeruginosa</i> is 5 fold higher than the other strains under investigation suggesting a possible role of this efflux pump in Sulfamethoxazole efflux. The findings suggest on the use of chitosans as enhancing agent in combination with antibiotics in pharmaceutical preparations.</p>http://www.biolsci.org/v05p0153.htm |
| spellingShingle | San Tin, Kishore R. Sakharkar, Chu Sing Lim, Meena K. Sakharkar Activity of Chitosans in combination with antibiotics in Pseudomonas aeruginosa International Journal of Biological Sciences |
| title | Activity of Chitosans in combination with antibiotics in Pseudomonas aeruginosa |
| title_full | Activity of Chitosans in combination with antibiotics in Pseudomonas aeruginosa |
| title_fullStr | Activity of Chitosans in combination with antibiotics in Pseudomonas aeruginosa |
| title_full_unstemmed | Activity of Chitosans in combination with antibiotics in Pseudomonas aeruginosa |
| title_short | Activity of Chitosans in combination with antibiotics in Pseudomonas aeruginosa |
| title_sort | activity of chitosans in combination with antibiotics in pseudomonas aeruginosa |
| url | http://www.biolsci.org/v05p0153.htm |
| work_keys_str_mv | AT santinkishorersakharkarchusinglimmeenaksakharkar activityofchitosansincombinationwithantibioticsinpseudomonasaeruginosa |