PROGRESSION OF ALBUMINURIA AND RETINOPATHY WITH DURATION OF DIABETES MELLITUS
Objective: To determine the progression of proteinuria with duration of type 2 diabetes mellitus, it also aimed at grading DR with duration of diabetes mellitus. Study Design: Cross sectional study. Place and Duration of Study: Duration of this study was 5 months, from Feb 2017 to Jun 2017. Mater...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2018-08-01
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| Series: | Pakistan Armed Forces Medical Journal |
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| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/72/49 |
| _version_ | 1818345017383583744 |
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| author | Azmat Ali Awais Saeed Abbasi Ahsan Nisar |
| author_facet | Azmat Ali Awais Saeed Abbasi Ahsan Nisar |
| author_sort | Azmat Ali |
| collection | DOAJ |
| description | Objective: To determine the progression of proteinuria with duration of type 2 diabetes mellitus, it also aimed at grading DR with duration of diabetes mellitus.
Study Design: Cross sectional study.
Place and Duration of Study: Duration of this study was 5 months, from Feb 2017 to Jun 2017.
Material and Methods: This study enrolled 53 patients with type 2 diabetes mellitus. Duration of this study was 5 months from February 2017 to June 2017. Urinary albumin was measured using the turbidometric method (Roche, Germany). A 3.5V Standard Ophthalmoscope (Welch Allyn) was used to examine the fundus. Statistical Package for Social Sciences (SPSS) version 20 was used for data analysis.
Results: In this study, 52.8% (n=28) were males while 47.1% (n=25) were females. Average age was 56.2 ± 11.6 years. Patients were grouped according to duration of diabetes; group1: disease duration less than 5 years, group 2: disease duration between 5 to 10 years, group 3: disease duration more than 10 years. Average HbA1C was 8.53% in group 1, 9.51 % in group 2 and 10% in group 3. In group 1, 22.6% (n=12) had urinary albumin less than 30 mg/dL. 16.9% (n=9) had urinary albumin equal to or more than 30 mg/dL and less than 300 mg/dL while no patient had urinary albumin equal to or more than 300 mg/dL. A p-value was 0.002. In group 2, 5.6% (n=3) had urinary albumin less than 30 mg/dL. Of 20.7% (n=11) had urinary albumin equal to or more than 30 mg/dL and less than 300 mg/dL while 1.8% (n=1) patient had urinary albumin equal to or more than 300 mg/dL. A p-value was 0.002. In group 3, No patient had urinary albumin less than 30 mg/dL. 18.8% (n=10) had urinary albumin equal to or more than 30 mg/dL and less than 300 mg/dL while 13.2% (n=7) patients had urinary albumin equal to or more than 300 mg/dL. A p-value was 0.001. In group 1, 1.8% (n=1) patient had DR. In group 2, 3.7% (n=2) patients had DR while in group 3, 20.1% (n=11) patients had DR. 45.3% of the patients were on oral hypoglycemic medications, 43.4% patients were on Insulin therapy while 9.4% patients were on Insulin and Oral Hypoglycemics both.
Conclusion: Patients had poor diabetic control despite being diagnosed for 5 to 10 years. Albuminuria progressed and grade of retinopathy increased with duration of diabetes. Relatively low rate of renal and retinal complications were found in this study. |
| first_indexed | 2024-12-13T16:55:41Z |
| format | Article |
| id | doaj.art-d367c0a60cfc474bb02e95f37311a5b3 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-13T16:55:41Z |
| publishDate | 2018-08-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-d367c0a60cfc474bb02e95f37311a5b32022-12-21T23:37:56ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422018-08-01684767772PROGRESSION OF ALBUMINURIA AND RETINOPATHY WITH DURATION OF DIABETES MELLITUSAzmat Ali0Awais Saeed Abbasi1Ahsan Nisar2KRL Hospital Islamabad PakistanKRL Hospital Islamabad PakistanKRL Hospital Islamabad PakistanObjective: To determine the progression of proteinuria with duration of type 2 diabetes mellitus, it also aimed at grading DR with duration of diabetes mellitus. Study Design: Cross sectional study. Place and Duration of Study: Duration of this study was 5 months, from Feb 2017 to Jun 2017. Material and Methods: This study enrolled 53 patients with type 2 diabetes mellitus. Duration of this study was 5 months from February 2017 to June 2017. Urinary albumin was measured using the turbidometric method (Roche, Germany). A 3.5V Standard Ophthalmoscope (Welch Allyn) was used to examine the fundus. Statistical Package for Social Sciences (SPSS) version 20 was used for data analysis. Results: In this study, 52.8% (n=28) were males while 47.1% (n=25) were females. Average age was 56.2 ± 11.6 years. Patients were grouped according to duration of diabetes; group1: disease duration less than 5 years, group 2: disease duration between 5 to 10 years, group 3: disease duration more than 10 years. Average HbA1C was 8.53% in group 1, 9.51 % in group 2 and 10% in group 3. In group 1, 22.6% (n=12) had urinary albumin less than 30 mg/dL. 16.9% (n=9) had urinary albumin equal to or more than 30 mg/dL and less than 300 mg/dL while no patient had urinary albumin equal to or more than 300 mg/dL. A p-value was 0.002. In group 2, 5.6% (n=3) had urinary albumin less than 30 mg/dL. Of 20.7% (n=11) had urinary albumin equal to or more than 30 mg/dL and less than 300 mg/dL while 1.8% (n=1) patient had urinary albumin equal to or more than 300 mg/dL. A p-value was 0.002. In group 3, No patient had urinary albumin less than 30 mg/dL. 18.8% (n=10) had urinary albumin equal to or more than 30 mg/dL and less than 300 mg/dL while 13.2% (n=7) patients had urinary albumin equal to or more than 300 mg/dL. A p-value was 0.001. In group 1, 1.8% (n=1) patient had DR. In group 2, 3.7% (n=2) patients had DR while in group 3, 20.1% (n=11) patients had DR. 45.3% of the patients were on oral hypoglycemic medications, 43.4% patients were on Insulin therapy while 9.4% patients were on Insulin and Oral Hypoglycemics both. Conclusion: Patients had poor diabetic control despite being diagnosed for 5 to 10 years. Albuminuria progressed and grade of retinopathy increased with duration of diabetes. Relatively low rate of renal and retinal complications were found in this study.https://www.pafmj.org/index.php/PAFMJ/article/view/72/49diabetic nephropathydiabetic retinopathydiabetes mellitushba1cmoderately increased albuminuriamicroalbuminuria |
| spellingShingle | Azmat Ali Awais Saeed Abbasi Ahsan Nisar PROGRESSION OF ALBUMINURIA AND RETINOPATHY WITH DURATION OF DIABETES MELLITUS Pakistan Armed Forces Medical Journal diabetic nephropathy diabetic retinopathy diabetes mellitus hba1c moderately increased albuminuria microalbuminuria |
| title | PROGRESSION OF ALBUMINURIA AND RETINOPATHY WITH DURATION OF DIABETES MELLITUS |
| title_full | PROGRESSION OF ALBUMINURIA AND RETINOPATHY WITH DURATION OF DIABETES MELLITUS |
| title_fullStr | PROGRESSION OF ALBUMINURIA AND RETINOPATHY WITH DURATION OF DIABETES MELLITUS |
| title_full_unstemmed | PROGRESSION OF ALBUMINURIA AND RETINOPATHY WITH DURATION OF DIABETES MELLITUS |
| title_short | PROGRESSION OF ALBUMINURIA AND RETINOPATHY WITH DURATION OF DIABETES MELLITUS |
| title_sort | progression of albuminuria and retinopathy with duration of diabetes mellitus |
| topic | diabetic nephropathy diabetic retinopathy diabetes mellitus hba1c moderately increased albuminuria microalbuminuria |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/72/49 |
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