Exposure of Keratinocytes to Candida Albicans in the Context of Atopic Milieu Induces Changes in the Surface Glycosylation Pattern of Small Extracellular Vesicles to Enhance Their Propensity to Interact With Inhibitory Siglec Receptors

Exposure of Keratinocytes to Candida Albicans in the Context of Atopic Milieu Induces Changes in the Surface Glycosylation Pattern of Small Extracellular Vesicles to Enhance Their Propensity to Interact With Inhibitory Siglec Receptors

Candida albicans (C. albicans) infection is a potential complication in the individuals with atopic dermatitis (AD) and can affect clinical course of the disease. Here, using primary keratinocytes we determined that atopic milieu promotes changes in the interaction of small extracellular vesicles (s...

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Main Authors: Adrian Kobiela, Joanna E. Frackowiak, Anna Biernacka, Lilit Hovhannisyan, Aleksandra E. Bogucka, Kinga Panek, Argho Aninda Paul, Joanna Lukomska, Xinwen Wang, Eleni Giannoulatou, Aleksandra Krolicka, Jacek Zielinski, Milena Deptula, Michal Pikula, Susanne Gabrielsson, Graham S. Ogg, Danuta Gutowska-Owsiak
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
Candida albicans
glycosylation
extracellular vesicle
keratinocyte
siglec
atopic dermatitis (AD)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.884530/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.884530/full

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