Drug Delivery and Therapy Strategies for Osteoporosis Intervention
With the advent of the aging society, osteoporosis (OP) risk increases yearly. Currently, the clinical usage of anti-OP drugs is challenged by recurrent side effects and poor patient compliance, regardless of oral, intravenous, or subcutaneous administration. Properly using a drug delivery system or...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/18/6652 |
| _version_ | 1797578562635563008 |
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| author | Mingyang Ma Huiling Zeng Pei Yang Jiabing Xu Xingwang Zhang Wei He |
| author_facet | Mingyang Ma Huiling Zeng Pei Yang Jiabing Xu Xingwang Zhang Wei He |
| author_sort | Mingyang Ma |
| collection | DOAJ |
| description | With the advent of the aging society, osteoporosis (OP) risk increases yearly. Currently, the clinical usage of anti-OP drugs is challenged by recurrent side effects and poor patient compliance, regardless of oral, intravenous, or subcutaneous administration. Properly using a drug delivery system or formulation strategy can achieve targeted drug delivery to the bone, diminish side effects, improve bioavailability, and prolong the in vivo residence time, thus effectively curing osteoporosis. This review expounds on the pathogenesis of OP and the clinical medicaments used for OP intervention, proposes the design approach for anti-OP drug delivery, emphatically discusses emerging novel anti-OP drug delivery systems, and enumerates anti-OP preparations under clinical investigation. Our findings may contribute to engineering anti-OP drug delivery and OP-targeting therapy. |
| first_indexed | 2024-03-10T22:24:34Z |
| format | Article |
| id | doaj.art-d36b30ed2c23444da6229bad1a8ac212 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T22:24:34Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d36b30ed2c23444da6229bad1a8ac2122023-11-19T12:10:30ZengMDPI AGMolecules1420-30492023-09-012818665210.3390/molecules28186652Drug Delivery and Therapy Strategies for Osteoporosis InterventionMingyang Ma0Huiling Zeng1Pei Yang2Jiabing Xu3Xingwang Zhang4Wei He5School of Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaSchool of Pharmacy, China Pharmaceutical University, Nanjing 211198, ChinaSchool of Science, China Pharmaceutical University, Nanjing 211198, ChinaTaizhou Institute for Drug Control, Taizhou 225316, ChinaDepartment of Pharmaceutics, School of Pharmacy, Jinan University, Guangzhou 510632, ChinaShanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, ChinaWith the advent of the aging society, osteoporosis (OP) risk increases yearly. Currently, the clinical usage of anti-OP drugs is challenged by recurrent side effects and poor patient compliance, regardless of oral, intravenous, or subcutaneous administration. Properly using a drug delivery system or formulation strategy can achieve targeted drug delivery to the bone, diminish side effects, improve bioavailability, and prolong the in vivo residence time, thus effectively curing osteoporosis. This review expounds on the pathogenesis of OP and the clinical medicaments used for OP intervention, proposes the design approach for anti-OP drug delivery, emphatically discusses emerging novel anti-OP drug delivery systems, and enumerates anti-OP preparations under clinical investigation. Our findings may contribute to engineering anti-OP drug delivery and OP-targeting therapy.https://www.mdpi.com/1420-3049/28/18/6652osteoporosisdrug deliverytargeted drug deliverybone tissue engineeringmicroneedles |
| spellingShingle | Mingyang Ma Huiling Zeng Pei Yang Jiabing Xu Xingwang Zhang Wei He Drug Delivery and Therapy Strategies for Osteoporosis Intervention Molecules osteoporosis drug delivery targeted drug delivery bone tissue engineering microneedles |
| title | Drug Delivery and Therapy Strategies for Osteoporosis Intervention |
| title_full | Drug Delivery and Therapy Strategies for Osteoporosis Intervention |
| title_fullStr | Drug Delivery and Therapy Strategies for Osteoporosis Intervention |
| title_full_unstemmed | Drug Delivery and Therapy Strategies for Osteoporosis Intervention |
| title_short | Drug Delivery and Therapy Strategies for Osteoporosis Intervention |
| title_sort | drug delivery and therapy strategies for osteoporosis intervention |
| topic | osteoporosis drug delivery targeted drug delivery bone tissue engineering microneedles |
| url | https://www.mdpi.com/1420-3049/28/18/6652 |
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