Termination of seizures by ictal transcranial focal cortex stimulation
Abstract Whereas high‐level evidence exists on chronic neuromodulatory effects of different brain stimulation approaches in reducing seizure frequency, evidence for acute antiseizure effects of electrical brain stimulation during seizures is sparse. As part of an ongoing trial, we implanted a patien...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Epilepsia Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/epi4.12728 |
| _version_ | 1797813830818988032 |
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| author | Martin Hirsch Volker Arnd Coenen Andreas Schulze‐Bonhage |
| author_facet | Martin Hirsch Volker Arnd Coenen Andreas Schulze‐Bonhage |
| author_sort | Martin Hirsch |
| collection | DOAJ |
| description | Abstract Whereas high‐level evidence exists on chronic neuromodulatory effects of different brain stimulation approaches in reducing seizure frequency, evidence for acute antiseizure effects of electrical brain stimulation during seizures is sparse. As part of an ongoing trial, we implanted a patient with a novel focal cortex stimulation (FCS) device with a Laplacian electrode placed over a precentral focal cortical dysplasia. The baseline seizure frequency was 125 per month, consisting of (i) focal aware sensory seizures that invariably progressed to uni‐ or bilateral tonic contraction and clonic jerking, and (ii) primary motor seizures. Besides an overall reduction in seizure frequency, on‐demand stimulation had an immediate effect on seizures with a sensory phase, whereby 63%‐86% of these seizures were terminated by ictal stimulation. These observations provide the first evidence that ictal self‐triggered transcranial focal cortex stimulation can significantly interfere with the progression of seizure semiology. |
| first_indexed | 2024-03-13T07:58:30Z |
| format | Article |
| id | doaj.art-d36bfbb87d2441ca98f4fd9cda2d2e2d |
| institution | Directory Open Access Journal |
| issn | 2470-9239 |
| language | English |
| last_indexed | 2024-03-13T07:58:30Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Epilepsia Open |
| spelling | doaj.art-d36bfbb87d2441ca98f4fd9cda2d2e2d2023-06-02T03:50:17ZengWileyEpilepsia Open2470-92392023-06-018267367710.1002/epi4.12728Termination of seizures by ictal transcranial focal cortex stimulationMartin Hirsch0Volker Arnd Coenen1Andreas Schulze‐Bonhage2Faculty of Medicine, Epilepsy Center University of Freiburg Freiburg GermanyDepartment of Stereotactic and Functional Neurosurgery Faculty of Medicine, University of Freiburg Freiburg GermanyFaculty of Medicine, Epilepsy Center University of Freiburg Freiburg GermanyAbstract Whereas high‐level evidence exists on chronic neuromodulatory effects of different brain stimulation approaches in reducing seizure frequency, evidence for acute antiseizure effects of electrical brain stimulation during seizures is sparse. As part of an ongoing trial, we implanted a patient with a novel focal cortex stimulation (FCS) device with a Laplacian electrode placed over a precentral focal cortical dysplasia. The baseline seizure frequency was 125 per month, consisting of (i) focal aware sensory seizures that invariably progressed to uni‐ or bilateral tonic contraction and clonic jerking, and (ii) primary motor seizures. Besides an overall reduction in seizure frequency, on‐demand stimulation had an immediate effect on seizures with a sensory phase, whereby 63%‐86% of these seizures were terminated by ictal stimulation. These observations provide the first evidence that ictal self‐triggered transcranial focal cortex stimulation can significantly interfere with the progression of seizure semiology.https://doi.org/10.1002/epi4.12728ictal stimulationneurostimulationseizure terminationtranscranial stimulation |
| spellingShingle | Martin Hirsch Volker Arnd Coenen Andreas Schulze‐Bonhage Termination of seizures by ictal transcranial focal cortex stimulation Epilepsia Open ictal stimulation neurostimulation seizure termination transcranial stimulation |
| title | Termination of seizures by ictal transcranial focal cortex stimulation |
| title_full | Termination of seizures by ictal transcranial focal cortex stimulation |
| title_fullStr | Termination of seizures by ictal transcranial focal cortex stimulation |
| title_full_unstemmed | Termination of seizures by ictal transcranial focal cortex stimulation |
| title_short | Termination of seizures by ictal transcranial focal cortex stimulation |
| title_sort | termination of seizures by ictal transcranial focal cortex stimulation |
| topic | ictal stimulation neurostimulation seizure termination transcranial stimulation |
| url | https://doi.org/10.1002/epi4.12728 |
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