Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study
Uterine leiomyoma (UL) is an estrogen-dependent neoplasm of the uterus, and estrogen metabolizing enzymes affect its progression. This study aimed to evaluate the association between two single-nucleotide polymorphisms of cytochrome P450 1A1 (CYP1A1) gene and UL risk. The study consisted of 105 pat...
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2016-08-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/1245 |
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| author | Saeedeh Salimi Mojtaba Sajadian Maryam Khodamian Atefeh Yazdi Soodabeh Rezaee Abbas Mohammadpour-Gharehbagh Mojgan Mokhtari Minoo Yaghmaie |
| author_facet | Saeedeh Salimi Mojtaba Sajadian Maryam Khodamian Atefeh Yazdi Soodabeh Rezaee Abbas Mohammadpour-Gharehbagh Mojgan Mokhtari Minoo Yaghmaie |
| author_sort | Saeedeh Salimi |
| collection | DOAJ |
| description |
Uterine leiomyoma (UL) is an estrogen-dependent neoplasm of the uterus, and estrogen metabolizing enzymes affect its progression. This study aimed to evaluate the association between two single-nucleotide polymorphisms of cytochrome P450 1A1 (CYP1A1) gene and UL risk. The study consisted of 105 patients with UL and 112 healthy women as controls. Ile462Val (A/G) and Asp449Asp (T/C) polymorphisms of CYP1A1 gene were analyzed by DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism methods, respectively. The findings indicated no association between Ile462Val (A/G) and Asp449Asp (T/C) polymorphisms of CYP1A1 gene and UL (p < 0.05). However, the combination effect of TT/AG genotypes of the Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms was associated with 4.3-fold higher risk of UL. In addition, haplotype analysis revealed that TG haplotype of the Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms could increase the UL risk nearly 4.9-fold. Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms of CYP1A1 gene were not associated with UL susceptibility; however, the combination of the TT/AG genotypes and TG haplotype could increase the UL risk.
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| first_indexed | 2024-04-24T23:32:53Z |
| format | Article |
| id | doaj.art-d36ca547298f4597b18ed31b91eea2ce |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:32:53Z |
| publishDate | 2016-08-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-d36ca547298f4597b18ed31b91eea2ce2024-03-15T14:31:52ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2016-08-0116310.17305/bjbms.2016.1245119Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control studySaeedeh Salimi0Mojtaba Sajadian1Maryam Khodamian2Atefeh Yazdi3Soodabeh Rezaee4Abbas Mohammadpour-Gharehbagh5Mojgan Mokhtari6Minoo Yaghmaie7Cellular and Molecular Research Center and Department of Clinical Biochemistry, School of Medicine,Zahedan University of Medical Sciences, Zahedan, IranCellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, IranZahedan University of Medical Sciences, Zahedan; School of Medicine, Zahedan University of Medical Sciences, ZahedanSchool of Medicine, Zahedan University of Medical Sciences, ZahedanSchool of Medicine, Zahedan University of Medical Sciences, ZahedanZahedan University of Medical Sciences, Zahedan; School of Medicine, Zahedan University of Medical Sciences, ZahedanSchool of Medicine, Zahedan University of Medical Sciences, Zahedan; Zahedan University of Medical Sciences, ZahedanSchool of Medicine, Shahid Beheshty University of Medical Sciences, Tehran Uterine leiomyoma (UL) is an estrogen-dependent neoplasm of the uterus, and estrogen metabolizing enzymes affect its progression. This study aimed to evaluate the association between two single-nucleotide polymorphisms of cytochrome P450 1A1 (CYP1A1) gene and UL risk. The study consisted of 105 patients with UL and 112 healthy women as controls. Ile462Val (A/G) and Asp449Asp (T/C) polymorphisms of CYP1A1 gene were analyzed by DNA sequencing and polymerase chain reaction-restriction fragment length polymorphism methods, respectively. The findings indicated no association between Ile462Val (A/G) and Asp449Asp (T/C) polymorphisms of CYP1A1 gene and UL (p < 0.05). However, the combination effect of TT/AG genotypes of the Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms was associated with 4.3-fold higher risk of UL. In addition, haplotype analysis revealed that TG haplotype of the Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms could increase the UL risk nearly 4.9-fold. Asp449Asp (T/C) and Ile462Val (A/G) polymorphisms of CYP1A1 gene were not associated with UL susceptibility; however, the combination of the TT/AG genotypes and TG haplotype could increase the UL risk. https://www.bjbms.org/ojs/index.php/bjbms/article/view/1245Cytochrome P450 1A1haplotypegenepolymorphismuterine leiomyoma |
| spellingShingle | Saeedeh Salimi Mojtaba Sajadian Maryam Khodamian Atefeh Yazdi Soodabeh Rezaee Abbas Mohammadpour-Gharehbagh Mojgan Mokhtari Minoo Yaghmaie Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study Biomolecules & Biomedicine Cytochrome P450 1A1 haplotype gene polymorphism uterine leiomyoma |
| title | Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study |
| title_full | Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study |
| title_fullStr | Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study |
| title_full_unstemmed | Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study |
| title_short | Combination effect of cytochrome P450 1A1 gene polymorphisms on uterine leiomyoma: A case-control study |
| title_sort | combination effect of cytochrome p450 1a1 gene polymorphisms on uterine leiomyoma a case control study |
| topic | Cytochrome P450 1A1 haplotype gene polymorphism uterine leiomyoma |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/1245 |
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