Glutathione Metabolism Contributes to the Induction of Trained Immunity

Glutathione Metabolism Contributes to the Induction of Trained Immunity

The innate immune system displays heterologous memory characteristics, which are characterized by stronger responses to a secondary challenge. This phenomenon termed trained immunity relies on epigenetic and metabolic rewiring of innate immune cells. As reactive oxygen species (ROS) production has b...

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Bibliographic Details
Main Authors: Anaisa V. Ferreira, Valerie A. C. M. Koeken, Vasiliki Matzaraki, Sarantos Kostidis, Juan Carlos Alarcon-Barrera, L. Charlotte J. de Bree, Simone J. C. F. M. Moorlag, Vera P. Mourits, Boris Novakovic, Martin A. Giera, Mihai G. Netea, Jorge Domínguez-Andrés
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
glutathione
trained immunity
macrophages
metabolism
innate immune memory
Online Access:https://www.mdpi.com/2073-4409/10/5/971

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