Coronavirus Disease 2019 (COVID-19) in Italy: Double Reading of Chest CT Examination
To assess the performance of the second reading of chest compute tomography (CT) examinations by expert radiologists in patients with discordance between the reverse transcription real-time fluorescence polymerase chain reaction (RT-PCR) test for COVID-19 viral pneumonia and the CT report. Three hun...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/10/2/89 |
| _version_ | 1797407597562691584 |
|---|---|
| author | Alfonso Reginelli Roberta Grassi Beatrice Feragalli Maria Paola Belfiore Alessandro Montanelli Gianluigi Patelli Michelearcangelo La Porta Fabrizio Urraro Roberta Fusco Vincenza Granata Antonella Petrillo Giuliana Giacobbe Gaetano Maria Russo Palmino Sacco Roberto Grassi Salvatore Cappabianca |
| author_facet | Alfonso Reginelli Roberta Grassi Beatrice Feragalli Maria Paola Belfiore Alessandro Montanelli Gianluigi Patelli Michelearcangelo La Porta Fabrizio Urraro Roberta Fusco Vincenza Granata Antonella Petrillo Giuliana Giacobbe Gaetano Maria Russo Palmino Sacco Roberto Grassi Salvatore Cappabianca |
| author_sort | Alfonso Reginelli |
| collection | DOAJ |
| description | To assess the performance of the second reading of chest compute tomography (CT) examinations by expert radiologists in patients with discordance between the reverse transcription real-time fluorescence polymerase chain reaction (RT-PCR) test for COVID-19 viral pneumonia and the CT report. Three hundred and seventy-eight patients were included in this retrospective study (121 women and 257 men; 71 years median age, with a range of 29–93 years) and subjected to RT-PCR tests for suspicious COVID-19 infection. All patients were subjected to CT examination in order to evaluate the pulmonary disease involvement by COVID-19. CT images were reviewed first by two radiologists who identified COVID-19 typical CT patterns and then reanalyzed by another two radiologists using a CT structured report for COVID-19 diagnosis. Weighted k values were used to evaluate the inter-reader agreement. The median temporal window between RT-PCRs execution and CT scan was zero days with a range of (−9, 11) days. The RT-PCR test was positive in 328/378 (86.8%). Discordance between RT-PCR and CT findings for viral pneumonia was revealed in 60 cases. The second reading changed the CT diagnosis in 16/60 (26.7%) cases contributing to an increase the concordance with the RT-PCR. Among these 60 cases, eight were false negative with positive RT-PCR, and 36 were false positive with negative RT-PCR. Sensitivity, specificity, positive predictive value and negative predictive value of CT were respectively of 97.3%, 53.8%, 89.0%, and 88.4%. Double reading of CT scans and expert second readers could increase the diagnostic confidence of radiological interpretation in COVID-19 patients. |
| first_indexed | 2024-03-09T03:43:51Z |
| format | Article |
| id | doaj.art-d36da792e6be4f0497d85a45223d78e1 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T03:43:51Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-d36da792e6be4f0497d85a45223d78e12023-12-03T14:36:34ZengMDPI AGBiology2079-77372021-01-011028910.3390/biology10020089Coronavirus Disease 2019 (COVID-19) in Italy: Double Reading of Chest CT ExaminationAlfonso Reginelli0Roberta Grassi1Beatrice Feragalli2Maria Paola Belfiore3Alessandro Montanelli4Gianluigi Patelli5Michelearcangelo La Porta6Fabrizio Urraro7Roberta Fusco8Vincenza Granata9Antonella Petrillo10Giuliana Giacobbe11Gaetano Maria Russo12Palmino Sacco13Roberto Grassi14Salvatore Cappabianca15Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, ItalyDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, ItalyOral and Biotechnological Sciences—Radiology Unit “G. D’Annunzio”, Department of Medical, University of Chieti-Pescara, 66100 Chieti, ItalyDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, ItalyLaboratory Medicine Unit, ASST Bergamo Est, 24068 Seriate, ItalyDepartment of Radiology, ASST Bergamo Est, 24068 Seriate, ItalyDepartment of Radiology, UOC San Severo Hospital, 71016 San Severo, ItalyDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, ItalyRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyRadiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale—IRCCS di Napoli, 80131 Naples, ItalyDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, ItalyDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, ItalyDiagnostic Imaging Unit, Department of Radiological Sciences, Azienda Ospedaliera Universitaria Senese, 53100 Siena, ItalyDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, ItalyDepartment of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, ItalyTo assess the performance of the second reading of chest compute tomography (CT) examinations by expert radiologists in patients with discordance between the reverse transcription real-time fluorescence polymerase chain reaction (RT-PCR) test for COVID-19 viral pneumonia and the CT report. Three hundred and seventy-eight patients were included in this retrospective study (121 women and 257 men; 71 years median age, with a range of 29–93 years) and subjected to RT-PCR tests for suspicious COVID-19 infection. All patients were subjected to CT examination in order to evaluate the pulmonary disease involvement by COVID-19. CT images were reviewed first by two radiologists who identified COVID-19 typical CT patterns and then reanalyzed by another two radiologists using a CT structured report for COVID-19 diagnosis. Weighted k values were used to evaluate the inter-reader agreement. The median temporal window between RT-PCRs execution and CT scan was zero days with a range of (−9, 11) days. The RT-PCR test was positive in 328/378 (86.8%). Discordance between RT-PCR and CT findings for viral pneumonia was revealed in 60 cases. The second reading changed the CT diagnosis in 16/60 (26.7%) cases contributing to an increase the concordance with the RT-PCR. Among these 60 cases, eight were false negative with positive RT-PCR, and 36 were false positive with negative RT-PCR. Sensitivity, specificity, positive predictive value and negative predictive value of CT were respectively of 97.3%, 53.8%, 89.0%, and 88.4%. Double reading of CT scans and expert second readers could increase the diagnostic confidence of radiological interpretation in COVID-19 patients.https://www.mdpi.com/2079-7737/10/2/89COVID-19chest CTstructured reportdouble readingradiological signs |
| spellingShingle | Alfonso Reginelli Roberta Grassi Beatrice Feragalli Maria Paola Belfiore Alessandro Montanelli Gianluigi Patelli Michelearcangelo La Porta Fabrizio Urraro Roberta Fusco Vincenza Granata Antonella Petrillo Giuliana Giacobbe Gaetano Maria Russo Palmino Sacco Roberto Grassi Salvatore Cappabianca Coronavirus Disease 2019 (COVID-19) in Italy: Double Reading of Chest CT Examination Biology COVID-19 chest CT structured report double reading radiological signs |
| title | Coronavirus Disease 2019 (COVID-19) in Italy: Double Reading of Chest CT Examination |
| title_full | Coronavirus Disease 2019 (COVID-19) in Italy: Double Reading of Chest CT Examination |
| title_fullStr | Coronavirus Disease 2019 (COVID-19) in Italy: Double Reading of Chest CT Examination |
| title_full_unstemmed | Coronavirus Disease 2019 (COVID-19) in Italy: Double Reading of Chest CT Examination |
| title_short | Coronavirus Disease 2019 (COVID-19) in Italy: Double Reading of Chest CT Examination |
| title_sort | coronavirus disease 2019 covid 19 in italy double reading of chest ct examination |
| topic | COVID-19 chest CT structured report double reading radiological signs |
| url | https://www.mdpi.com/2079-7737/10/2/89 |
| work_keys_str_mv | AT alfonsoreginelli coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT robertagrassi coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT beatriceferagalli coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT mariapaolabelfiore coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT alessandromontanelli coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT gianluigipatelli coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT michelearcangelolaporta coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT fabriziourraro coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT robertafusco coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT vincenzagranata coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT antonellapetrillo coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT giulianagiacobbe coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT gaetanomariarusso coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT palminosacco coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT robertograssi coronavirusdisease2019covid19initalydoublereadingofchestctexamination AT salvatorecappabianca coronavirusdisease2019covid19initalydoublereadingofchestctexamination |