Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

The dual-specificity tyrosine phosphorylation-regulated kinase DYRK2 has emerged as a critical regulator of cellular processes. We took a chemical biology approach to gain further insights into its function. We developed C17, a potent small-molecule DYRK2 inhibitor, through multiple rounds of struct...

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Bibliographic Details
Main Authors: Tiantian Wei, Jue Wang, Ruqi Liang, Wendong Chen, Yilan Chen, Mingzhe Ma, An He, Yifei Du, Wenjing Zhou, Zhiying Zhang, Xin Zeng, Chu Wang, Jin Lu, Xing Guo, Xiao-Wei Chen, Youjun Wang, Ruijun Tian, Junyu Xiao, Xiaoguang Lei
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
chemical biology
kinase
cancer
protein synthesis
Online Access:https://elifesciences.org/articles/77696

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