AhR-mediated, non-genomic modulation of IDO1 function.

AhR-mediated, non-genomic modulation of IDO1 function.

The evolutionary process has conferred a dual – enzymic and signaling – function on the ancestral metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which has long been known for converting the essential amino acid tryptophan into neuroactive and immunoactive catabolites (kynurenines). In additi...

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Bibliographic Details
Main Authors: Maria Teresa Pallotta, Francesca eFallarino, Davide eMatino, Antonio eMacchiarulo, Ciriana eOrabona
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Immunology
Subjects:
AhR
dendritic cells.
Immunoregulation
Ubiquitin ligase complex
ITIM
L-kynurenine
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00497/full

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