Evaluation of serum MicroRNA expression profiles in patients with panic disorder
BACKGROUND: Studies on the role of microRNAs (miRNA) in anxiety disorders are limited. We aimed to determine the availability of miRNAs as biomarkers in serum and to demonstrate the changes of miRNAs expression in patients with panic disorder (PD). METHODS: Thirty-five patients with PD and 35 health...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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AVES
2019-01-01
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| Series: | Psychiatry and Clinical Psychopharmacology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/24750573.2018.1429844 |
| _version_ | 1828016499228409856 |
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| author | Fikret Poyraz Çökmüş Erol Özmen Tunç Alkin Muhammet Burak Batir Fethi Sırrı Çam |
| author_facet | Fikret Poyraz Çökmüş Erol Özmen Tunç Alkin Muhammet Burak Batir Fethi Sırrı Çam |
| author_sort | Fikret Poyraz Çökmüş |
| collection | DOAJ |
| description | BACKGROUND: Studies on the role of microRNAs (miRNA) in anxiety disorders are limited. We aimed to determine the availability of miRNAs as biomarkers in serum and to demonstrate the changes of miRNAs expression in patients with panic disorder (PD). METHODS: Thirty-five patients with PD and 35 healthy controls (HC) were evaluated with Structured Clinical Interview for DSM Disorders-I (SCID-I) and Panic Disorder Severity Scale (PDSS). In each group miRNA expression analysis was performed in venous blood by the Real-time Polymerase Chain Reaction (RT–PCR) method for genetic evaluation. RESULTS: Compared with the HC group, eight miRNA expression levels were found different in the PD group. Five of them were upregulated and three of them were downregulated. There was no correlation between the levels of miRNA expression with PDSS total score and PDSS sub-items. However, miR-1297 and miR-4465 expression levels were significantly different between the two groups. LIMITATIONS: There are some limitations in this research. Firstly the number of samples is small. Another limitation of our study is that the presence of medical illness and continuous drug use were not excluded when PD and HC groups were selected. CONCLUSIONS: Our research is the first miRNA expression study in patients with PD which excluded psychotropic use and additional psychiatric disorders. In the PD group, miR-1297 and miR-4465 expression was upregulated than compared to the HC group. miR-1297 and miR-4465 regulate the GABAA gene regions that affect GABAA receptor subtypes that thought to play a role in the aetiology of PD. |
| first_indexed | 2024-04-10T10:33:39Z |
| format | Article |
| id | doaj.art-d3729faec5904d398332843ba5770aa4 |
| institution | Directory Open Access Journal |
| issn | 2475-0573 2475-0581 |
| language | English |
| last_indexed | 2024-04-10T10:33:39Z |
| publishDate | 2019-01-01 |
| publisher | AVES |
| record_format | Article |
| series | Psychiatry and Clinical Psychopharmacology |
| spelling | doaj.art-d3729faec5904d398332843ba5770aa42023-02-15T16:20:58ZengAVESPsychiatry and Clinical Psychopharmacology2475-05732475-05812019-01-0129181310.1080/24750573.2018.14298441429844Evaluation of serum MicroRNA expression profiles in patients with panic disorderFikret Poyraz Çökmüş0Erol Özmen1Tunç Alkin2Muhammet Burak Batir3Fethi Sırrı Çam4Nazilli State HospitalManisa Celal Bayar University Hospital9 Eylül University HospitalManisa Celal Bayar University HospitalManisa Celal Bayar University HospitalBACKGROUND: Studies on the role of microRNAs (miRNA) in anxiety disorders are limited. We aimed to determine the availability of miRNAs as biomarkers in serum and to demonstrate the changes of miRNAs expression in patients with panic disorder (PD). METHODS: Thirty-five patients with PD and 35 healthy controls (HC) were evaluated with Structured Clinical Interview for DSM Disorders-I (SCID-I) and Panic Disorder Severity Scale (PDSS). In each group miRNA expression analysis was performed in venous blood by the Real-time Polymerase Chain Reaction (RT–PCR) method for genetic evaluation. RESULTS: Compared with the HC group, eight miRNA expression levels were found different in the PD group. Five of them were upregulated and three of them were downregulated. There was no correlation between the levels of miRNA expression with PDSS total score and PDSS sub-items. However, miR-1297 and miR-4465 expression levels were significantly different between the two groups. LIMITATIONS: There are some limitations in this research. Firstly the number of samples is small. Another limitation of our study is that the presence of medical illness and continuous drug use were not excluded when PD and HC groups were selected. CONCLUSIONS: Our research is the first miRNA expression study in patients with PD which excluded psychotropic use and additional psychiatric disorders. In the PD group, miR-1297 and miR-4465 expression was upregulated than compared to the HC group. miR-1297 and miR-4465 regulate the GABAA gene regions that affect GABAA receptor subtypes that thought to play a role in the aetiology of PD.http://dx.doi.org/10.1080/24750573.2018.1429844AnxietyepigeneticmiR-1297miR-4465panic disorder |
| spellingShingle | Fikret Poyraz Çökmüş Erol Özmen Tunç Alkin Muhammet Burak Batir Fethi Sırrı Çam Evaluation of serum MicroRNA expression profiles in patients with panic disorder Psychiatry and Clinical Psychopharmacology Anxiety epigenetic miR-1297 miR-4465 panic disorder |
| title | Evaluation of serum MicroRNA expression profiles in patients with panic disorder |
| title_full | Evaluation of serum MicroRNA expression profiles in patients with panic disorder |
| title_fullStr | Evaluation of serum MicroRNA expression profiles in patients with panic disorder |
| title_full_unstemmed | Evaluation of serum MicroRNA expression profiles in patients with panic disorder |
| title_short | Evaluation of serum MicroRNA expression profiles in patients with panic disorder |
| title_sort | evaluation of serum microrna expression profiles in patients with panic disorder |
| topic | Anxiety epigenetic miR-1297 miR-4465 panic disorder |
| url | http://dx.doi.org/10.1080/24750573.2018.1429844 |
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