Effect of glucosamine and acetylsalicylic acid preparations on the skin histostructure after acute cold trauma
Aim. The study of the glucosamine and acetylsalicylic acid action on the morphological changes of the foot pads of hindlegs and the tip of rats’ tail after acute cold trauma (CT). Materials and methods. Rats were modeled CT in the Nord Inter-300 freezer at –18 °C for 2 hours. The study drugs – ac...
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2018-07-01
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| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/135381/136189 |
| _version_ | 1819026720634699776 |
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| author | Ye. V. Bondariev S. Yu. Shtryhol S. M. Drohovoz Yu. B. Larianovska |
| author_facet | Ye. V. Bondariev S. Yu. Shtryhol S. M. Drohovoz Yu. B. Larianovska |
| author_sort | Ye. V. Bondariev |
| collection | DOAJ |
| description | Aim. The study of the glucosamine and acetylsalicylic acid action on the morphological changes of the foot pads of hindlegs and the tip of rats’ tail after acute cold trauma (CT).
Materials and methods. Rats were modeled CT in the Nord Inter-300 freezer at –18 °C for 2 hours. The study drugs – acetylsalicylic acid (25 mg/kg), "Glucosamine-C BHFZ" (82.5 mg/kg) and glucosamine hydrochloride (50 mg/kg) were administered prophylactically 30 min before acute CT.
Results. Glucosamine hydrochloride and "Glucosamine-C BHFZ"It has been determined to have a marked positive effect on the rat skin histological structure in comparison with the reference drug (acetylsalicylic acid).
Conclusions. The most marked frigoprotective effect had glucosamine hydrochloride and "Glucosamine-C BHFZ" as with administration of which there were no inflammatory reactions in the dermis and microcirculation disturbances were not observed. In the group of animals treated with glucosamine hydrochloride the histological structure corresponded to the intact control group. Acetylsalicylic acid did not restore the animals’ skin histological structure as pronounced hyperkeratosis, keratinocytes dystrophy and inflammatory reaction in the dermis and in the subcutaneous adipose tissue were observed. |
| first_indexed | 2024-12-21T05:31:04Z |
| format | Article |
| id | doaj.art-d373eb2d17344cbc98bcfdf22967608d |
| institution | Directory Open Access Journal |
| issn | 2306-4145 2310-1210 |
| language | English |
| last_indexed | 2024-12-21T05:31:04Z |
| publishDate | 2018-07-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj.art-d373eb2d17344cbc98bcfdf22967608d2022-12-21T19:14:33ZengZaporozhye State Medical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102018-07-01456857310.14739/2310-1210.2018.4.135381Effect of glucosamine and acetylsalicylic acid preparations on the skin histostructure after acute cold traumaYe. V. BondarievS. Yu. Shtryhol S. M. DrohovozYu. B. LarianovskaAim. The study of the glucosamine and acetylsalicylic acid action on the morphological changes of the foot pads of hindlegs and the tip of rats’ tail after acute cold trauma (CT). Materials and methods. Rats were modeled CT in the Nord Inter-300 freezer at –18 °C for 2 hours. The study drugs – acetylsalicylic acid (25 mg/kg), "Glucosamine-C BHFZ" (82.5 mg/kg) and glucosamine hydrochloride (50 mg/kg) were administered prophylactically 30 min before acute CT. Results. Glucosamine hydrochloride and "Glucosamine-C BHFZ"It has been determined to have a marked positive effect on the rat skin histological structure in comparison with the reference drug (acetylsalicylic acid). Conclusions. The most marked frigoprotective effect had glucosamine hydrochloride and "Glucosamine-C BHFZ" as with administration of which there were no inflammatory reactions in the dermis and microcirculation disturbances were not observed. In the group of animals treated with glucosamine hydrochloride the histological structure corresponded to the intact control group. Acetylsalicylic acid did not restore the animals’ skin histological structure as pronounced hyperkeratosis, keratinocytes dystrophy and inflammatory reaction in the dermis and in the subcutaneous adipose tissue were observed.http://zmj.zsmu.edu.ua/article/view/135381/136189cold injuryphysiological stressglucosamineaspirin |
| spellingShingle | Ye. V. Bondariev S. Yu. Shtryhol S. M. Drohovoz Yu. B. Larianovska Effect of glucosamine and acetylsalicylic acid preparations on the skin histostructure after acute cold trauma Zaporožskij Medicinskij Žurnal cold injury physiological stress glucosamine aspirin |
| title | Effect of glucosamine and acetylsalicylic acid preparations on the skin histostructure after acute cold trauma |
| title_full | Effect of glucosamine and acetylsalicylic acid preparations on the skin histostructure after acute cold trauma |
| title_fullStr | Effect of glucosamine and acetylsalicylic acid preparations on the skin histostructure after acute cold trauma |
| title_full_unstemmed | Effect of glucosamine and acetylsalicylic acid preparations on the skin histostructure after acute cold trauma |
| title_short | Effect of glucosamine and acetylsalicylic acid preparations on the skin histostructure after acute cold trauma |
| title_sort | effect of glucosamine and acetylsalicylic acid preparations on the skin histostructure after acute cold trauma |
| topic | cold injury physiological stress glucosamine aspirin |
| url | http://zmj.zsmu.edu.ua/article/view/135381/136189 |
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