Metabolomics in rheumatoid arthritis: Advances and review
Rheumatoid arthritis (RA) is an autoimmune disease accompanied by metabolic alterations. The metabolic profiles of patients with RA can be determined using targeted and non-targeted metabolomics technology. Metabolic changes in glucose, lipid, and amino acid levels are involved in glycolysis, the tr...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.961708/full |
| _version_ | 1811321809515053056 |
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| author | Lingxia Xu Lingxia Xu Lingxia Xu Cen Chang Cen Chang Cen Chang Ping Jiang Ping Jiang Ping Jiang Kai Wei Kai Wei Kai Wei Runrun Zhang Yehua Jin Yehua Jin Jianan Zhao Jianan Zhao Jianan Zhao Linshuai Xu Linshuai Xu Yiming Shi Yiming Shi Yiming Shi Shicheng Guo Shicheng Guo Dongyi He Dongyi He Dongyi He |
| author_facet | Lingxia Xu Lingxia Xu Lingxia Xu Cen Chang Cen Chang Cen Chang Ping Jiang Ping Jiang Ping Jiang Kai Wei Kai Wei Kai Wei Runrun Zhang Yehua Jin Yehua Jin Jianan Zhao Jianan Zhao Jianan Zhao Linshuai Xu Linshuai Xu Yiming Shi Yiming Shi Yiming Shi Shicheng Guo Shicheng Guo Dongyi He Dongyi He Dongyi He |
| author_sort | Lingxia Xu |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) is an autoimmune disease accompanied by metabolic alterations. The metabolic profiles of patients with RA can be determined using targeted and non-targeted metabolomics technology. Metabolic changes in glucose, lipid, and amino acid levels are involved in glycolysis, the tricarboxylic acid cycle, the pentose phosphate pathway, the arachidonic acid metabolic pathway, and amino acid metabolism. These alterations in metabolic pathways and metabolites can fulfill bio-energetic requirements, promote cell proliferation, drive inflammatory mediator secretion, mediate leukocyte infiltration, induce joint destruction and muscle atrophy, and regulate cell proliferation, which may reflect the etiologies of RA. Differential metabolites can be used as biomarkers for the diagnosis, prognosis, and risk prediction, improving the specificity and accuracy of diagnostics and prognosis prediction. Additionally, metabolic changes associated with therapeutic responses can improve the understanding of drug mechanism. Metabolic homeostasis and regulation are new therapeutic strategies for RA. In this review, we provide a comprehensive overview of advances in metabolomics for RA. |
| first_indexed | 2024-04-13T13:24:18Z |
| format | Article |
| id | doaj.art-d3749dff4b5445d3a0c17e7212d386db |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T13:24:18Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d3749dff4b5445d3a0c17e7212d386db2022-12-22T02:45:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.961708961708Metabolomics in rheumatoid arthritis: Advances and reviewLingxia Xu0Lingxia Xu1Lingxia Xu2Cen Chang3Cen Chang4Cen Chang5Ping Jiang6Ping Jiang7Ping Jiang8Kai Wei9Kai Wei10Kai Wei11Runrun Zhang12Yehua Jin13Yehua Jin14Jianan Zhao15Jianan Zhao16Jianan Zhao17Linshuai Xu18Linshuai Xu19Yiming Shi20Yiming Shi21Yiming Shi22Shicheng Guo23Shicheng Guo24Dongyi He25Dongyi He26Dongyi He27Guanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Medical Genetics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, United StatesComputation and Informatics in Biology and Medicine, University of Wisconsin-Madison, Madison, WI, United StatesGuanghua Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, ChinaRheumatoid arthritis (RA) is an autoimmune disease accompanied by metabolic alterations. The metabolic profiles of patients with RA can be determined using targeted and non-targeted metabolomics technology. Metabolic changes in glucose, lipid, and amino acid levels are involved in glycolysis, the tricarboxylic acid cycle, the pentose phosphate pathway, the arachidonic acid metabolic pathway, and amino acid metabolism. These alterations in metabolic pathways and metabolites can fulfill bio-energetic requirements, promote cell proliferation, drive inflammatory mediator secretion, mediate leukocyte infiltration, induce joint destruction and muscle atrophy, and regulate cell proliferation, which may reflect the etiologies of RA. Differential metabolites can be used as biomarkers for the diagnosis, prognosis, and risk prediction, improving the specificity and accuracy of diagnostics and prognosis prediction. Additionally, metabolic changes associated with therapeutic responses can improve the understanding of drug mechanism. Metabolic homeostasis and regulation are new therapeutic strategies for RA. In this review, we provide a comprehensive overview of advances in metabolomics for RA.https://www.frontiersin.org/articles/10.3389/fimmu.2022.961708/fullrheumatoid arthritismetabolomicspathogenesismedicinebiomarkers |
| spellingShingle | Lingxia Xu Lingxia Xu Lingxia Xu Cen Chang Cen Chang Cen Chang Ping Jiang Ping Jiang Ping Jiang Kai Wei Kai Wei Kai Wei Runrun Zhang Yehua Jin Yehua Jin Jianan Zhao Jianan Zhao Jianan Zhao Linshuai Xu Linshuai Xu Yiming Shi Yiming Shi Yiming Shi Shicheng Guo Shicheng Guo Dongyi He Dongyi He Dongyi He Metabolomics in rheumatoid arthritis: Advances and review Frontiers in Immunology rheumatoid arthritis metabolomics pathogenesis medicine biomarkers |
| title | Metabolomics in rheumatoid arthritis: Advances and review |
| title_full | Metabolomics in rheumatoid arthritis: Advances and review |
| title_fullStr | Metabolomics in rheumatoid arthritis: Advances and review |
| title_full_unstemmed | Metabolomics in rheumatoid arthritis: Advances and review |
| title_short | Metabolomics in rheumatoid arthritis: Advances and review |
| title_sort | metabolomics in rheumatoid arthritis advances and review |
| topic | rheumatoid arthritis metabolomics pathogenesis medicine biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.961708/full |
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