Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells
Axonal myelination by oligodendrocytes increases the speed and reliability of action potential propagation, and so plays a pivotal role in cortical information processing. The extent and profile of myelination vary between different cortical layers and groups of neurons. Two subtypes of cortical GAB...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/3/216 |
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| author | Elisa Mazuir Desdemona Fricker Nathalie Sol-Foulon |
| author_facet | Elisa Mazuir Desdemona Fricker Nathalie Sol-Foulon |
| author_sort | Elisa Mazuir |
| collection | DOAJ |
| description | Axonal myelination by oligodendrocytes increases the speed and reliability of action potential propagation, and so plays a pivotal role in cortical information processing. The extent and profile of myelination vary between different cortical layers and groups of neurons. Two subtypes of cortical GABAergic neurons are myelinated: fast-spiking parvalbumin-expressing cells and somatostatin-containing cells. The expression of pre-nodes on the axon of these inhibitory cells before myelination illuminates communication between oligodendrocytes and neurons. We explore the consequences of myelination for action potential propagation, for patterns of neuronal connectivity and for the expression of behavioral plasticity. |
| first_indexed | 2024-03-10T13:25:34Z |
| format | Article |
| id | doaj.art-d374dde272dc47e5b0a9eb18b64772c1 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T13:25:34Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-d374dde272dc47e5b0a9eb18b64772c12023-11-21T09:41:18ZengMDPI AGLife2075-17292021-03-0111321610.3390/life11030216Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic CellsElisa Mazuir0Desdemona Fricker1Nathalie Sol-Foulon2Inserm, CNRS, Paris Brain Institute, ICM, Sorbonne University, Pitié-Salpêtrière Hospital, F-75013 Paris, FranceCNRS UMR 8002, Integrative Neuroscience and Cognition Center, Université de Paris, F-75006 Paris, FranceInserm, CNRS, Paris Brain Institute, ICM, Sorbonne University, Pitié-Salpêtrière Hospital, F-75013 Paris, FranceAxonal myelination by oligodendrocytes increases the speed and reliability of action potential propagation, and so plays a pivotal role in cortical information processing. The extent and profile of myelination vary between different cortical layers and groups of neurons. Two subtypes of cortical GABAergic neurons are myelinated: fast-spiking parvalbumin-expressing cells and somatostatin-containing cells. The expression of pre-nodes on the axon of these inhibitory cells before myelination illuminates communication between oligodendrocytes and neurons. We explore the consequences of myelination for action potential propagation, for patterns of neuronal connectivity and for the expression of behavioral plasticity.https://www.mdpi.com/2075-1729/11/3/216Myelinoligodendrocytesoligodendrocyte lineage cellsGABAergic neuronsinterneuronsfast-spiking PV<sup>+</sup> cells |
| spellingShingle | Elisa Mazuir Desdemona Fricker Nathalie Sol-Foulon Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells Life Myelin oligodendrocytes oligodendrocyte lineage cells GABAergic neurons interneurons fast-spiking PV<sup>+</sup> cells |
| title | Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells |
| title_full | Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells |
| title_fullStr | Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells |
| title_full_unstemmed | Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells |
| title_short | Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells |
| title_sort | neuron oligodendrocyte communication in myelination of cortical gabaergic cells |
| topic | Myelin oligodendrocytes oligodendrocyte lineage cells GABAergic neurons interneurons fast-spiking PV<sup>+</sup> cells |
| url | https://www.mdpi.com/2075-1729/11/3/216 |
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