Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination
In 2016, an outbreak of mumps occurred in a primary school in China with a student population having high vaccination coverage. An unmatched case-control study was performed to identify risk factors contributing to this outbreak, and a retrospective cohort study was conducted to evaluate the effecti...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-09-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | http://dx.doi.org/10.1080/21645515.2019.1581526 |
| _version_ | 1797677441211170816 |
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| author | Wei Qin Yao Wang Tao Yang Xiao-Kang Xu Xiang-Mei Meng Chang-Jun Zhao Shao-Yi Li Shao-Yu Xie Kai-Chun Li Hong Su |
| author_facet | Wei Qin Yao Wang Tao Yang Xiao-Kang Xu Xiang-Mei Meng Chang-Jun Zhao Shao-Yi Li Shao-Yu Xie Kai-Chun Li Hong Su |
| author_sort | Wei Qin |
| collection | DOAJ |
| description | In 2016, an outbreak of mumps occurred in a primary school in China with a student population having high vaccination coverage. An unmatched case-control study was performed to identify risk factors contributing to this outbreak, and a retrospective cohort study was conducted to evaluate the effectiveness of mumps-containing vaccine (MuCV). A total of 97 cases were identified during the outbreak, and the overall attack rate was 8.2%. Among students with confirmed vaccination status, 90% had received at least one dose of MuCV. Cases were more likely than non-cases to report taking the school bus during the epidemic period (adjusted OR = 2.3, 95% CI: 1.4–3.7). Vaccine effectiveness (VE) was higher for two-dose MuCV (76%, 95% CI:49–89%) than for one-dose MuCV (59%, 95% CI: 36–74%. The protection afforded by both one-dose and two-dose MuCV waned over time, from 82% among students vaccinated within 5 years to 41% among those vaccinated more than 10 years previously for one-dose VE, and from 90% to 25% over the same time period for two-dose VE. We found that outbreaks of mumps can occur in schools despite high coverage of one-dose MuCV vaccination. Although the VE of both two-dose and one-dose MuCV wanes over time, the overall VE for two-dose MuCV was superior than that of one-dose MuCV. Therefore, a two-dose MuCV schedule through routine services is likely needed in order to control mumps epidemics in China. |
| first_indexed | 2024-03-11T22:45:14Z |
| format | Article |
| id | doaj.art-d37539e05602410397bbc9f1c1ec19be |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:45:14Z |
| publishDate | 2019-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-d37539e05602410397bbc9f1c1ec19be2023-09-22T08:38:26ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2019-09-011592106211110.1080/21645515.2019.15815261581526Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccinationWei Qin0Yao Wang1Tao Yang2Xiao-Kang Xu3Xiang-Mei Meng4Chang-Jun Zhao5Shao-Yi Li6Shao-Yu Xie7Kai-Chun Li8Hong Su9Lu’an Municipal Center for Disease Control and PreventionLu’an Municipal Center for Disease Control and PreventionLu’an Municipal Center for Disease Control and PreventionLu’an Municipal Center for Disease Control and PreventionLu’an Municipal Center for Disease Control and PreventionJin’an District Center for Disease Control and PreventionJin’an District Center for Disease Control and PreventionLu’an Municipal Center for Disease Control and PreventionLu’an Municipal Center for Disease Control and PreventionSchool of Public Health, Anhui Medical UniversityIn 2016, an outbreak of mumps occurred in a primary school in China with a student population having high vaccination coverage. An unmatched case-control study was performed to identify risk factors contributing to this outbreak, and a retrospective cohort study was conducted to evaluate the effectiveness of mumps-containing vaccine (MuCV). A total of 97 cases were identified during the outbreak, and the overall attack rate was 8.2%. Among students with confirmed vaccination status, 90% had received at least one dose of MuCV. Cases were more likely than non-cases to report taking the school bus during the epidemic period (adjusted OR = 2.3, 95% CI: 1.4–3.7). Vaccine effectiveness (VE) was higher for two-dose MuCV (76%, 95% CI:49–89%) than for one-dose MuCV (59%, 95% CI: 36–74%. The protection afforded by both one-dose and two-dose MuCV waned over time, from 82% among students vaccinated within 5 years to 41% among those vaccinated more than 10 years previously for one-dose VE, and from 90% to 25% over the same time period for two-dose VE. We found that outbreaks of mumps can occur in schools despite high coverage of one-dose MuCV vaccination. Although the VE of both two-dose and one-dose MuCV wanes over time, the overall VE for two-dose MuCV was superior than that of one-dose MuCV. Therefore, a two-dose MuCV schedule through routine services is likely needed in order to control mumps epidemics in China.http://dx.doi.org/10.1080/21645515.2019.1581526mumpsvaccine effectivenessrisk factorsoutbreak |
| spellingShingle | Wei Qin Yao Wang Tao Yang Xiao-Kang Xu Xiang-Mei Meng Chang-Jun Zhao Shao-Yi Li Shao-Yu Xie Kai-Chun Li Hong Su Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination Human Vaccines & Immunotherapeutics mumps vaccine effectiveness risk factors outbreak |
| title | Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination |
| title_full | Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination |
| title_fullStr | Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination |
| title_full_unstemmed | Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination |
| title_short | Outbreak of mumps in a student population with high vaccination coverage in China: time for two-dose vaccination |
| title_sort | outbreak of mumps in a student population with high vaccination coverage in china time for two dose vaccination |
| topic | mumps vaccine effectiveness risk factors outbreak |
| url | http://dx.doi.org/10.1080/21645515.2019.1581526 |
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