Polymorphism of Folate metabolism genes and risk of lung cancer
Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality worldwide. Folate metabolism plays an important role in carcinogenesis through its involvement in the process of dNamethylation and repair.The aim of our study was to evaluate the relationship between MTHFR С...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2019-04-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/1017 |
| _version_ | 1826563748011180032 |
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| author | M. L. Bakanova V. I. Minina Ya. A. Savchenko A. N. Glushkov |
| author_facet | M. L. Bakanova V. I. Minina Ya. A. Savchenko A. N. Glushkov |
| author_sort | M. L. Bakanova |
| collection | DOAJ |
| description | Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality worldwide. Folate metabolism plays an important role in carcinogenesis through its involvement in the process of dNamethylation and repair.The aim of our study was to evaluate the relationship between MTHFR С677Т (rs1801133), MTR A2756G (rs1805087), MTRR А66G (rs1801394) gene polymorphisms and lung cancer risk.Material and methods. Asystematic literature search was conducted in the electronic databases pubmed, elibrary.ru in the time period between 2003 and 2018.Results. The MTHFR C677Tand MTRR А66G gene polymorphisms were found to be significantly associated with lung cancer. No significant association between the MTR A2756Gpolymorphism and lung cancer risk was found. the variant alleles of MTR 2756A > Gand MTRR 66A > Gpolymorphisms may have a joint effect on lung cancer risk. anumber of factors, such as nationality, smoking, gender, and an accurate diagnosis can influence the results of studies on the role of genes involved in folate cycle in patients with lung cancer.Conclusion. Future studies are needed to consider gene-gene and gene-environment interactions in lung cancer. Further investigations on MTHFR С677Т (rs1801133), MTR A2756G (rs1805087), MTRR А66G (rs1801394) polymorphisms and lung cancer susceptibility may provide a theoretical basis for lung cancer prevention. |
| first_indexed | 2024-04-10T01:53:42Z |
| format | Article |
| id | doaj.art-d375731f34de44df8bf6e123a7e460cc |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2025-03-14T10:08:53Z |
| publishDate | 2019-04-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-d375731f34de44df8bf6e123a7e460cc2025-03-02T11:16:11ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682019-04-01182707710.21294/1814-4861-2019-18-2-70-77629Polymorphism of Folate metabolism genes and risk of lung cancerM. L. Bakanova0V. I. Minina1Ya. A. Savchenko2A. N. Glushkov3Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences.Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences.Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences.Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences.Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer mortality worldwide. Folate metabolism plays an important role in carcinogenesis through its involvement in the process of dNamethylation and repair.The aim of our study was to evaluate the relationship between MTHFR С677Т (rs1801133), MTR A2756G (rs1805087), MTRR А66G (rs1801394) gene polymorphisms and lung cancer risk.Material and methods. Asystematic literature search was conducted in the electronic databases pubmed, elibrary.ru in the time period between 2003 and 2018.Results. The MTHFR C677Tand MTRR А66G gene polymorphisms were found to be significantly associated with lung cancer. No significant association between the MTR A2756Gpolymorphism and lung cancer risk was found. the variant alleles of MTR 2756A > Gand MTRR 66A > Gpolymorphisms may have a joint effect on lung cancer risk. anumber of factors, such as nationality, smoking, gender, and an accurate diagnosis can influence the results of studies on the role of genes involved in folate cycle in patients with lung cancer.Conclusion. Future studies are needed to consider gene-gene and gene-environment interactions in lung cancer. Further investigations on MTHFR С677Т (rs1801133), MTR A2756G (rs1805087), MTRR А66G (rs1801394) polymorphisms and lung cancer susceptibility may provide a theoretical basis for lung cancer prevention.https://www.siboncoj.ru/jour/article/view/1017lung cancergenetic polymorphism of folate metabolism genes mthfrmtrmtrrdnametabolismoncogenesis |
| spellingShingle | M. L. Bakanova V. I. Minina Ya. A. Savchenko A. N. Glushkov Polymorphism of Folate metabolism genes and risk of lung cancer Сибирский онкологический журнал lung cancer genetic polymorphism of folate metabolism genes mthfr mtr mtrr dna metabolism oncogenesis |
| title | Polymorphism of Folate metabolism genes and risk of lung cancer |
| title_full | Polymorphism of Folate metabolism genes and risk of lung cancer |
| title_fullStr | Polymorphism of Folate metabolism genes and risk of lung cancer |
| title_full_unstemmed | Polymorphism of Folate metabolism genes and risk of lung cancer |
| title_short | Polymorphism of Folate metabolism genes and risk of lung cancer |
| title_sort | polymorphism of folate metabolism genes and risk of lung cancer |
| topic | lung cancer genetic polymorphism of folate metabolism genes mthfr mtr mtrr dna metabolism oncogenesis |
| url | https://www.siboncoj.ru/jour/article/view/1017 |
| work_keys_str_mv | AT mlbakanova polymorphismoffolatemetabolismgenesandriskoflungcancer AT viminina polymorphismoffolatemetabolismgenesandriskoflungcancer AT yaasavchenko polymorphismoffolatemetabolismgenesandriskoflungcancer AT anglushkov polymorphismoffolatemetabolismgenesandriskoflungcancer |