An insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus.
Central insulin resistance (IR) influences striatal dopamine (DA) tone, an important determinant of behavioral self-regulation. We hypothesized that an association exists between the degree of peripheral IR and impulse control, mediated by the impact of IR on brain circuits controlling the speed of...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5724830?pdf=render |
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| author | Kristen L Eckstrand Nishit Mummareddy Hakmook Kang Ronald Cowan Minchun Zhou David Zald Heidi J Silver Kevin D Niswender Malcolm J Avison |
| author_facet | Kristen L Eckstrand Nishit Mummareddy Hakmook Kang Ronald Cowan Minchun Zhou David Zald Heidi J Silver Kevin D Niswender Malcolm J Avison |
| author_sort | Kristen L Eckstrand |
| collection | DOAJ |
| description | Central insulin resistance (IR) influences striatal dopamine (DA) tone, an important determinant of behavioral self-regulation. We hypothesized that an association exists between the degree of peripheral IR and impulse control, mediated by the impact of IR on brain circuits controlling the speed of executing "go" and/or "stop" responses. We measured brain activation and associated performance on a stop signal task (SST) in obese adults with type 2 diabetes (age, 48.1 ± 6.9 yrs (mean ± SD); BMI, 36.5 ± 4.0 kg/m2; HOMA-IR, 7.2 ± 4.1; 12 male, 18 female). Increasing IR, but not BMI, was a predictor of shorter critical stop signal delay (cSSD), a measure of the time window during which a go response can be successfully countermanded (R2 = 0.12). This decline was explained by an IR-associated increase in go speed (R2 = 0.13) with little impact of IR or BMI on stop speed. Greater striatal fMRI activation contrast in stop error (SE) compared with stop success (SS) trials (CONSE>SS) was a significant predictor of faster go speeds (R2 = 0.33, p = 0.002), and was itself predicted by greater IR (CONSE>SS vs HOMA-IR: R2 = 0.10, p = 0.04). Furthermore, this impact of IR on striatal activation was a significant mediator of the faster go speeds and greater impulsivity observed with greater IR. These findings suggest a neural mechanism by which IR may increase impulsivity and degrade behavioral self-regulation. |
| first_indexed | 2024-12-11T08:38:12Z |
| format | Article |
| id | doaj.art-d377112acfb04a9d996c3c178728c5b1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T08:38:12Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d377112acfb04a9d996c3c178728c5b12022-12-22T01:14:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011212e018911310.1371/journal.pone.0189113An insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus.Kristen L EckstrandNishit MummareddyHakmook KangRonald CowanMinchun ZhouDavid ZaldHeidi J SilverKevin D NiswenderMalcolm J AvisonCentral insulin resistance (IR) influences striatal dopamine (DA) tone, an important determinant of behavioral self-regulation. We hypothesized that an association exists between the degree of peripheral IR and impulse control, mediated by the impact of IR on brain circuits controlling the speed of executing "go" and/or "stop" responses. We measured brain activation and associated performance on a stop signal task (SST) in obese adults with type 2 diabetes (age, 48.1 ± 6.9 yrs (mean ± SD); BMI, 36.5 ± 4.0 kg/m2; HOMA-IR, 7.2 ± 4.1; 12 male, 18 female). Increasing IR, but not BMI, was a predictor of shorter critical stop signal delay (cSSD), a measure of the time window during which a go response can be successfully countermanded (R2 = 0.12). This decline was explained by an IR-associated increase in go speed (R2 = 0.13) with little impact of IR or BMI on stop speed. Greater striatal fMRI activation contrast in stop error (SE) compared with stop success (SS) trials (CONSE>SS) was a significant predictor of faster go speeds (R2 = 0.33, p = 0.002), and was itself predicted by greater IR (CONSE>SS vs HOMA-IR: R2 = 0.10, p = 0.04). Furthermore, this impact of IR on striatal activation was a significant mediator of the faster go speeds and greater impulsivity observed with greater IR. These findings suggest a neural mechanism by which IR may increase impulsivity and degrade behavioral self-regulation.http://europepmc.org/articles/PMC5724830?pdf=render |
| spellingShingle | Kristen L Eckstrand Nishit Mummareddy Hakmook Kang Ronald Cowan Minchun Zhou David Zald Heidi J Silver Kevin D Niswender Malcolm J Avison An insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus. PLoS ONE |
| title | An insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus. |
| title_full | An insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus. |
| title_fullStr | An insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus. |
| title_full_unstemmed | An insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus. |
| title_short | An insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus. |
| title_sort | insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus |
| url | http://europepmc.org/articles/PMC5724830?pdf=render |
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