Heterologous Challenge with PRRSV-1 MLV in Pregnant Vaccinated Gilts: Potential Risk on Health and Immunity of Piglets
The objective of the present study was to evaluate the potential risks of the four commercial PRRS-1 MLV vaccines in pregnant vaccinated gilts at the last stage of gestation under field conditions. The study was conducted at four pig farms, including 25 gilts from each farm (25 × 4 = 100 gilts), whi...
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MDPI AG
2022-02-01
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| Online Access: | https://www.mdpi.com/2076-2615/12/4/450 |
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| author | Georgios Papakonstantinou Eleftherios Meletis Georgios Christodoulopoulos Eleni D. Tzika Polychronis Kostoulas Vasileios G. Papatsiros |
| author_facet | Georgios Papakonstantinou Eleftherios Meletis Georgios Christodoulopoulos Eleni D. Tzika Polychronis Kostoulas Vasileios G. Papatsiros |
| author_sort | Georgios Papakonstantinou |
| collection | DOAJ |
| description | The objective of the present study was to evaluate the potential risks of the four commercial PRRS-1 MLV vaccines in pregnant vaccinated gilts at the last stage of gestation under field conditions. The study was conducted at four pig farms, including 25 gilts from each farm (25 × 4 = 100 gilts), which were equally allocated to five different study groups. A PRRS-1 MLV vaccination was applied on the 100th day of their pregnancy with the different commercial vaccines that are available in the Greek market. The results indicated virus congenital infection and viremia in piglets (20/200 = 10% PRRSV infected piglets), and detection of PRRSV-specific antibodies (181/200 = 90.5% piglets found with PRRSV antibodies). The subsequent phylogenetic analyses revealed high percentages of similarity between the PRRSV-1 strain detected in infected litters and the PRRSV-1 vaccine strain to which the study gilts had been previously exposed to. Health status analyses of trial piglets resulted in differences between litters from vaccinated sows and litters from non-vaccinated sows at 110th day of gestation as regards the number of weak-born piglets, mummies, and piglets with splay-leg and/or respiratory symptoms. The current study’s results indicate several potential dangers of the PRRS MLV vaccination in late gestation. |
| first_indexed | 2024-03-09T22:48:47Z |
| format | Article |
| id | doaj.art-d37baa1da0e9438990a06805d2a476e5 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-09T22:48:47Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-d37baa1da0e9438990a06805d2a476e52023-11-23T18:25:19ZengMDPI AGAnimals2076-26152022-02-0112445010.3390/ani12040450Heterologous Challenge with PRRSV-1 MLV in Pregnant Vaccinated Gilts: Potential Risk on Health and Immunity of PigletsGeorgios Papakonstantinou0Eleftherios Meletis1Georgios Christodoulopoulos2Eleni D. Tzika3Polychronis Kostoulas4Vasileios G. Papatsiros5Clinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, 43100 Karditsa, GreeceLaboratory of Epidemiology & Artificial Intelligence, Faculty of Public Health, School of Health Sciences, University of Thessaly, 43100 Karditsa, GreeceClinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, 43100 Karditsa, GreeceFarm Animals Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, 54627 Thessaloniki, GreeceLaboratory of Epidemiology & Artificial Intelligence, Faculty of Public Health, School of Health Sciences, University of Thessaly, 43100 Karditsa, GreeceClinic of Medicine, Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, 43100 Karditsa, GreeceThe objective of the present study was to evaluate the potential risks of the four commercial PRRS-1 MLV vaccines in pregnant vaccinated gilts at the last stage of gestation under field conditions. The study was conducted at four pig farms, including 25 gilts from each farm (25 × 4 = 100 gilts), which were equally allocated to five different study groups. A PRRS-1 MLV vaccination was applied on the 100th day of their pregnancy with the different commercial vaccines that are available in the Greek market. The results indicated virus congenital infection and viremia in piglets (20/200 = 10% PRRSV infected piglets), and detection of PRRSV-specific antibodies (181/200 = 90.5% piglets found with PRRSV antibodies). The subsequent phylogenetic analyses revealed high percentages of similarity between the PRRSV-1 strain detected in infected litters and the PRRSV-1 vaccine strain to which the study gilts had been previously exposed to. Health status analyses of trial piglets resulted in differences between litters from vaccinated sows and litters from non-vaccinated sows at 110th day of gestation as regards the number of weak-born piglets, mummies, and piglets with splay-leg and/or respiratory symptoms. The current study’s results indicate several potential dangers of the PRRS MLV vaccination in late gestation.https://www.mdpi.com/2076-2615/12/4/450PRRSVantibodiesMLV vaccinesafetypiglet |
| spellingShingle | Georgios Papakonstantinou Eleftherios Meletis Georgios Christodoulopoulos Eleni D. Tzika Polychronis Kostoulas Vasileios G. Papatsiros Heterologous Challenge with PRRSV-1 MLV in Pregnant Vaccinated Gilts: Potential Risk on Health and Immunity of Piglets Animals PRRSV antibodies MLV vaccine safety piglet |
| title | Heterologous Challenge with PRRSV-1 MLV in Pregnant Vaccinated Gilts: Potential Risk on Health and Immunity of Piglets |
| title_full | Heterologous Challenge with PRRSV-1 MLV in Pregnant Vaccinated Gilts: Potential Risk on Health and Immunity of Piglets |
| title_fullStr | Heterologous Challenge with PRRSV-1 MLV in Pregnant Vaccinated Gilts: Potential Risk on Health and Immunity of Piglets |
| title_full_unstemmed | Heterologous Challenge with PRRSV-1 MLV in Pregnant Vaccinated Gilts: Potential Risk on Health and Immunity of Piglets |
| title_short | Heterologous Challenge with PRRSV-1 MLV in Pregnant Vaccinated Gilts: Potential Risk on Health and Immunity of Piglets |
| title_sort | heterologous challenge with prrsv 1 mlv in pregnant vaccinated gilts potential risk on health and immunity of piglets |
| topic | PRRSV antibodies MLV vaccine safety piglet |
| url | https://www.mdpi.com/2076-2615/12/4/450 |
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