γ-2 and GSG1L bind with comparable affinities to the tetrameric GluA1 core

γ-2 and GSG1L bind with comparable affinities to the tetrameric GluA1 core

Abstract Background The AMPA-type ionotropic glutamate receptor mediates fast excitatory neurotransmission in the brain. A variety of auxiliary subunits regulate its gating properties, assembly, and trafficking, but it is unknown if the binding of these auxiliary subunits to the receptor core is dyn...

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Bibliographic Details
Main Authors: Chenlu Yu, Hendrik F. P. Runge, Antara Mukhopadhyay, Gerd Zolles, Maximilian H. Ulbrich
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Cellular & Molecular Biology Letters
Subjects:
Receptor assembly
Subunit stoichiometry
AMPA receptor regulatory subunits
Single-molecule imaging
Online Access:https://doi.org/10.1186/s11658-023-00470-9

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