Innate Immune Training of Human Macrophages by Cathelicidin Analogs

Innate Immune Training of Human Macrophages by Cathelicidin Analogs

Trained innate immunity can be induced in human macrophages by microbial ligands, but it is unknown if exposure to endogenous alarmins such as cathelicidins can have similar effects. Previously, we demonstrated sustained protection against infection by the chicken cathelicidin-2 analog DCATH-2. Thus...

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Bibliographic Details
Main Authors: Albert van Dijk, Jennifer Anten, Anne Bakker, Noah Evers, Anna T. Hoekstra, Jung-Chin Chang, Maaike R. Scheenstra, Edwin J. A. Veldhuizen, Mihai G. Netea, Celia R. Berkers, Henk P. Haagsman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
host defense peptide
cathelicidin
macrophage
trained immunity
immunomodulation
metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.777530/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.777530/full

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