Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain
IntroductionChronic pain is one of the leading causes of disability that may accelerate biological aging and reduce physical function. Epigenetic clocks provide an estimate of how the system ages and can predict health outcomes such as physical function. Physical function declines may be attributed...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1122364/full |
| _version_ | 1827981630830018560 |
|---|---|
| author | Jessica A. Peterson Jessica A. Peterson Joshua A. Crow Joshua A. Crow Alisa J. Johnson Alisa J. Johnson Lingsong Meng Asha Rani Zhiguang Huo Thomas C. Foster Thomas C. Foster Roger B. Fillingim Roger B. Fillingim Yenisel Cruz-Almeida Yenisel Cruz-Almeida Yenisel Cruz-Almeida |
| author_facet | Jessica A. Peterson Jessica A. Peterson Joshua A. Crow Joshua A. Crow Alisa J. Johnson Alisa J. Johnson Lingsong Meng Asha Rani Zhiguang Huo Thomas C. Foster Thomas C. Foster Roger B. Fillingim Roger B. Fillingim Yenisel Cruz-Almeida Yenisel Cruz-Almeida Yenisel Cruz-Almeida |
| author_sort | Jessica A. Peterson |
| collection | DOAJ |
| description | IntroductionChronic pain is one of the leading causes of disability that may accelerate biological aging and reduce physical function. Epigenetic clocks provide an estimate of how the system ages and can predict health outcomes such as physical function. Physical function declines may be attributed to decreases in muscle quality due to disuse that can be measured quickly and noninvasively using grip strength. The purpose of this study was to explore the associations among self-reported pain, grip strength, and epigenetic aging in those with chronic pain.MethodsParticipants (57.91 ± 8.04 years) completed pain questionnaires, a blood draw and hand grip strength task. We used an epigenetic clock previously associated with knee pain (DNAmGrimAge), and used the subsequent difference of predicted epigenetic age from chronological age (DNAmGrimAge-Difference).ResultsExploratory pathway analyses revealed that pain intensity mediated the association between DNAmGrimAge-difference and handgrip strength in males only (β = −0.1115; CI [−0.2929, −0.0008]) and pain interference mediated the association between DNAmGrimAge-difference and handgrip strength in males β = −0.1401; CI [−0.3400, −0.0222]), and females (β = −0.024; CI [−0.2918, −0.0020]).DiscussionChronic knee pain may accelerate epigenetic aging processes that may influence handgrip strength in older age adults. Chronic pain could be a symptom of the aging body thus contributing to declines in musculoskeletal function in later life. |
| first_indexed | 2024-04-09T22:11:04Z |
| format | Article |
| id | doaj.art-d3818217c6ef44e7834a626ca2d40dc7 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-09T22:11:04Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-d3818217c6ef44e7834a626ca2d40dc72023-03-23T10:54:17ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-03-011510.3389/fnagi.2023.11223641122364Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic painJessica A. Peterson0Jessica A. Peterson1Joshua A. Crow2Joshua A. Crow3Alisa J. Johnson4Alisa J. Johnson5Lingsong Meng6Asha Rani7Zhiguang Huo8Thomas C. Foster9Thomas C. Foster10Roger B. Fillingim11Roger B. Fillingim12Yenisel Cruz-Almeida13Yenisel Cruz-Almeida14Yenisel Cruz-Almeida15Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, United StatesDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, United StatesPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, United StatesDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, United StatesPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, United StatesDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, United StatesDepartment of Biostatistics, University of Florida, Gainesville, FL, United StatesDepartment of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, United StatesDepartment of Biostatistics, University of Florida, Gainesville, FL, United StatesDepartment of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, United StatesGenetics and Genomics Program, University of Florida, Gainesville, FL, United StatesPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, United StatesDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, United StatesPain Research and Intervention Center of Excellence, University of Florida, Gainesville, FL, United StatesDepartment of Community Dentistry and Behavioral Science, University of Florida, Gainesville, FL, United StatesDepartment of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL, United StatesIntroductionChronic pain is one of the leading causes of disability that may accelerate biological aging and reduce physical function. Epigenetic clocks provide an estimate of how the system ages and can predict health outcomes such as physical function. Physical function declines may be attributed to decreases in muscle quality due to disuse that can be measured quickly and noninvasively using grip strength. The purpose of this study was to explore the associations among self-reported pain, grip strength, and epigenetic aging in those with chronic pain.MethodsParticipants (57.91 ± 8.04 years) completed pain questionnaires, a blood draw and hand grip strength task. We used an epigenetic clock previously associated with knee pain (DNAmGrimAge), and used the subsequent difference of predicted epigenetic age from chronological age (DNAmGrimAge-Difference).ResultsExploratory pathway analyses revealed that pain intensity mediated the association between DNAmGrimAge-difference and handgrip strength in males only (β = −0.1115; CI [−0.2929, −0.0008]) and pain interference mediated the association between DNAmGrimAge-difference and handgrip strength in males β = −0.1401; CI [−0.3400, −0.0222]), and females (β = −0.024; CI [−0.2918, −0.0020]).DiscussionChronic knee pain may accelerate epigenetic aging processes that may influence handgrip strength in older age adults. Chronic pain could be a symptom of the aging body thus contributing to declines in musculoskeletal function in later life.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1122364/fullpaindisabilityepigenetic aginghand grip strengthphysical function |
| spellingShingle | Jessica A. Peterson Jessica A. Peterson Joshua A. Crow Joshua A. Crow Alisa J. Johnson Alisa J. Johnson Lingsong Meng Asha Rani Zhiguang Huo Thomas C. Foster Thomas C. Foster Roger B. Fillingim Roger B. Fillingim Yenisel Cruz-Almeida Yenisel Cruz-Almeida Yenisel Cruz-Almeida Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain Frontiers in Aging Neuroscience pain disability epigenetic aging hand grip strength physical function |
| title | Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain |
| title_full | Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain |
| title_fullStr | Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain |
| title_full_unstemmed | Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain |
| title_short | Pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain |
| title_sort | pain interference mediates the association between epigenetic aging and grip strength in middle to older aged males and females with chronic pain |
| topic | pain disability epigenetic aging hand grip strength physical function |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1122364/full |
| work_keys_str_mv | AT jessicaapeterson paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT jessicaapeterson paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT joshuaacrow paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT joshuaacrow paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT alisajjohnson paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT alisajjohnson paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT lingsongmeng paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT asharani paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT zhiguanghuo paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT thomascfoster paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT thomascfoster paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT rogerbfillingim paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT rogerbfillingim paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT yeniselcruzalmeida paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT yeniselcruzalmeida paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain AT yeniselcruzalmeida paininterferencemediatestheassociationbetweenepigeneticagingandgripstrengthinmiddletoolderagedmalesandfemaleswithchronicpain |