Investigation of the pharmacological treatment patterns of Chinese patients with major depressive disorder under real-world settings using multi-channel sequence analysis
BackgroundDespite many treatment guidelines available now, the treatment patterns of major depressive disorder (MDD) in China haven't been well-understood due to complexity and diversity.AimTo describe pharmacological treatment patterns of MDD patients in real-world settings using electronic he...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1089504/full |
| _version_ | 1797851399287996416 |
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| author | Tao Wu Sijia Dong Lu Yang Hong Qiu Hong Qiu David Mellor Jun Chen Jun Chen Jun Chen Yifeng Xu |
| author_facet | Tao Wu Sijia Dong Lu Yang Hong Qiu Hong Qiu David Mellor Jun Chen Jun Chen Jun Chen Yifeng Xu |
| author_sort | Tao Wu |
| collection | DOAJ |
| description | BackgroundDespite many treatment guidelines available now, the treatment patterns of major depressive disorder (MDD) in China haven't been well-understood due to complexity and diversity.AimTo describe pharmacological treatment patterns of MDD patients in real-world settings using electronic health records from a major psychiatric hospital in China.MethodsMDD patients (18–65 years, ICD-10: F32.x, F33.x) newly initiated single antidepressant (AD) in 2015 were enrolled, the date of first AD prescription during the study period was defined as index date, and eligible patients were followed up to 1 year. Treatment patterns were revealed and analyzed using multi-channel sequence analysis (MCSA), considering patients' chronological sequences (in days) of AD prescription, cumulative treatment step(s), and polypharmacy usage during the follow-up.ResultsThis study (n = 5,003) identified four types of MDD treatment patterns. The first type (1-time treatment) represents the largest proportion of patients (73.6%, n = 3,686), followed by the second type (6-month consistent treatment) and third type (long-term, consistent treatment) collectively accounted for 20.6% (n = 1,031) of patients, by contrast the last type (long-term, inconsistent treatment) made up the rest 5.7% (n = 286) of patients while exhibiting the most complicated treatments patterns. The choice of AD was dominated by selective serotonin reuptake inhibitors (SSRIs), while treatment duration spent in polypharmacy spanned at 2.8%, 16.4%, 2.0%, and 36.5% over the four types, respectively.ConclusionTreatment patterns reflecting real-world pharmacological treatment practices of MDD in China were revealed using MCSA. The observed discrepancies between real-world practice and treatment guidelines provided additional insights in improving the clinical management of MDD. |
| first_indexed | 2024-04-09T19:17:16Z |
| format | Article |
| id | doaj.art-d381b643b89c4d74b17e23f14e6b3a79 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-09T19:17:16Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-d381b643b89c4d74b17e23f14e6b3a792023-04-06T05:06:45ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-04-011410.3389/fpsyt.2023.10895041089504Investigation of the pharmacological treatment patterns of Chinese patients with major depressive disorder under real-world settings using multi-channel sequence analysisTao Wu0Sijia Dong1Lu Yang2Hong Qiu3Hong Qiu4David Mellor5Jun Chen6Jun Chen7Jun Chen8Yifeng Xu9Global Epidemiology, Office of Chief Medical Officer, Johnson & Johnson, Beijing, ChinaGlobal Epidemiology, Office of Chief Medical Officer, Johnson & Johnson, Shanghai, ChinaClinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaClinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaGlobal Epidemiology, Office of Chief Medical Officer, Johnson & Johnson, Titusville, NJ, United StatesSchool of Psychology, Deakin University, Melbourne, VIC, AustraliaClinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaCenter for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, ChinaShanghai Key Laboratory of Psychotic Disorders, Shanghai, ChinaClinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaBackgroundDespite many treatment guidelines available now, the treatment patterns of major depressive disorder (MDD) in China haven't been well-understood due to complexity and diversity.AimTo describe pharmacological treatment patterns of MDD patients in real-world settings using electronic health records from a major psychiatric hospital in China.MethodsMDD patients (18–65 years, ICD-10: F32.x, F33.x) newly initiated single antidepressant (AD) in 2015 were enrolled, the date of first AD prescription during the study period was defined as index date, and eligible patients were followed up to 1 year. Treatment patterns were revealed and analyzed using multi-channel sequence analysis (MCSA), considering patients' chronological sequences (in days) of AD prescription, cumulative treatment step(s), and polypharmacy usage during the follow-up.ResultsThis study (n = 5,003) identified four types of MDD treatment patterns. The first type (1-time treatment) represents the largest proportion of patients (73.6%, n = 3,686), followed by the second type (6-month consistent treatment) and third type (long-term, consistent treatment) collectively accounted for 20.6% (n = 1,031) of patients, by contrast the last type (long-term, inconsistent treatment) made up the rest 5.7% (n = 286) of patients while exhibiting the most complicated treatments patterns. The choice of AD was dominated by selective serotonin reuptake inhibitors (SSRIs), while treatment duration spent in polypharmacy spanned at 2.8%, 16.4%, 2.0%, and 36.5% over the four types, respectively.ConclusionTreatment patterns reflecting real-world pharmacological treatment practices of MDD in China were revealed using MCSA. The observed discrepancies between real-world practice and treatment guidelines provided additional insights in improving the clinical management of MDD.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1089504/fullmajor depressive disorderantidepressantsmulti-channel sequence analysistreatment patternselectronic health records |
| spellingShingle | Tao Wu Sijia Dong Lu Yang Hong Qiu Hong Qiu David Mellor Jun Chen Jun Chen Jun Chen Yifeng Xu Investigation of the pharmacological treatment patterns of Chinese patients with major depressive disorder under real-world settings using multi-channel sequence analysis Frontiers in Psychiatry major depressive disorder antidepressants multi-channel sequence analysis treatment patterns electronic health records |
| title | Investigation of the pharmacological treatment patterns of Chinese patients with major depressive disorder under real-world settings using multi-channel sequence analysis |
| title_full | Investigation of the pharmacological treatment patterns of Chinese patients with major depressive disorder under real-world settings using multi-channel sequence analysis |
| title_fullStr | Investigation of the pharmacological treatment patterns of Chinese patients with major depressive disorder under real-world settings using multi-channel sequence analysis |
| title_full_unstemmed | Investigation of the pharmacological treatment patterns of Chinese patients with major depressive disorder under real-world settings using multi-channel sequence analysis |
| title_short | Investigation of the pharmacological treatment patterns of Chinese patients with major depressive disorder under real-world settings using multi-channel sequence analysis |
| title_sort | investigation of the pharmacological treatment patterns of chinese patients with major depressive disorder under real world settings using multi channel sequence analysis |
| topic | major depressive disorder antidepressants multi-channel sequence analysis treatment patterns electronic health records |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1089504/full |
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