A permutation test for oligoset DNA pooling studies.
Case-control association studies often suffer from population stratification bias. A previous triple combination strategy of stratum matching, genomic controlling, and multiple DNA pooling can correct the bias and save genotyping cost. However the method requires researchers to prepare a multitude o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4357378?pdf=render |
| _version_ | 1818133255368474624 |
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| author | Hsiao-Yuan Huang Jui-Hsiang Lin Wen-Chung Lee |
| author_facet | Hsiao-Yuan Huang Jui-Hsiang Lin Wen-Chung Lee |
| author_sort | Hsiao-Yuan Huang |
| collection | DOAJ |
| description | Case-control association studies often suffer from population stratification bias. A previous triple combination strategy of stratum matching, genomic controlling, and multiple DNA pooling can correct the bias and save genotyping cost. However the method requires researchers to prepare a multitude of DNA pools-more than 30 case-control pooling sets in total (polyset). In this paper, the authors propose a permutation test for oligoset DNA pooling studies. Monte-Carlo simulations show that the proposed test has a type I error rate under control and a power comparable to that of individual genotyping. For a researcher on a tight budget, oligoset DNA pooling is a viable option. |
| first_indexed | 2024-12-11T08:49:49Z |
| format | Article |
| id | doaj.art-d384a44187e9493ba2ca26cc48dabd22 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T08:49:49Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d384a44187e9493ba2ca26cc48dabd222022-12-22T01:14:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e011909610.1371/journal.pone.0119096A permutation test for oligoset DNA pooling studies.Hsiao-Yuan HuangJui-Hsiang LinWen-Chung LeeCase-control association studies often suffer from population stratification bias. A previous triple combination strategy of stratum matching, genomic controlling, and multiple DNA pooling can correct the bias and save genotyping cost. However the method requires researchers to prepare a multitude of DNA pools-more than 30 case-control pooling sets in total (polyset). In this paper, the authors propose a permutation test for oligoset DNA pooling studies. Monte-Carlo simulations show that the proposed test has a type I error rate under control and a power comparable to that of individual genotyping. For a researcher on a tight budget, oligoset DNA pooling is a viable option.http://europepmc.org/articles/PMC4357378?pdf=render |
| spellingShingle | Hsiao-Yuan Huang Jui-Hsiang Lin Wen-Chung Lee A permutation test for oligoset DNA pooling studies. PLoS ONE |
| title | A permutation test for oligoset DNA pooling studies. |
| title_full | A permutation test for oligoset DNA pooling studies. |
| title_fullStr | A permutation test for oligoset DNA pooling studies. |
| title_full_unstemmed | A permutation test for oligoset DNA pooling studies. |
| title_short | A permutation test for oligoset DNA pooling studies. |
| title_sort | permutation test for oligoset dna pooling studies |
| url | http://europepmc.org/articles/PMC4357378?pdf=render |
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