An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy
<p>Abstract</p> <p>Background</p> <p>Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involv...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2006-12-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/6/298 |
| _version_ | 1818144873490939904 |
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| author | Chen Liyong Zhang Yan Zhang Dong Song Santai Song Yuhua Qian Lu Shi Ming Zhao Huibin Jiang Zefei Guo Ning |
| author_facet | Chen Liyong Zhang Yan Zhang Dong Song Santai Song Yuhua Qian Lu Shi Ming Zhao Huibin Jiang Zefei Guo Ning |
| author_sort | Chen Liyong |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significance of Fra-1 expression in breast carcinogenesis.</p> <p>Methods</p> <p>The expression of Fra-1 was investigated by immunohistochemistry in neoplastic breast diseases ranging from benign fibroadenoma to very aggressive undifferentiated carcinoma. The correlations of Fra-1 expression with other indicators of breast carcinoma prognosis (ER, PR and ErbB2 receptors) were analyzed.</p> <p>Results</p> <p>All neoplastic breast tissues, either benign or malignant breast tissues, were nuclear immunoreactive for Fra-1-recognizing antibody. The pattern of Fra-1 expression by benign neoplastic cells was predominantly nuclear. However, the nuclear/cytoplasmic concomitant immunoreactivity was observed in all types of breast carcinomas. A clear shift in Fra-1 immunoreactivity, from an exclusively nuclear to a simultaneous nuclear and cytoplasmic localization was noticed in ~90% of breast carcinomas.</p> <p>Conclusion</p> <p>The overall expression, pattern and intensity of Fra-1 proteins were correlated with breast oncogenesis. Overexpression of Fra-1, leading to a persistent high cytoplasmic accumulation, may play a role in the process of breast carcinogenesis.</p> |
| first_indexed | 2024-12-11T11:54:29Z |
| format | Article |
| id | doaj.art-d3852399ca9e41c1b4488ee9a4f8671a |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T11:54:29Z |
| publishDate | 2006-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-d3852399ca9e41c1b4488ee9a4f8671a2022-12-22T01:08:16ZengBMCBMC Cancer1471-24072006-12-016129810.1186/1471-2407-6-298An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancyChen LiyongZhang YanZhang DongSong SantaiSong YuhuaQian LuShi MingZhao HuibinJiang ZefeiGuo Ning<p>Abstract</p> <p>Background</p> <p>Overexpression of Fra-1 in fibroblasts causes anchorage-independent cell growth and oncogenic transformation. A high level of Fra-1 expression is found in various tumors and tumorigenic cell lines, suggesting that Fra-1 may be involved in malignant progression. This study aimed to investigate the significance of Fra-1 expression in breast carcinogenesis.</p> <p>Methods</p> <p>The expression of Fra-1 was investigated by immunohistochemistry in neoplastic breast diseases ranging from benign fibroadenoma to very aggressive undifferentiated carcinoma. The correlations of Fra-1 expression with other indicators of breast carcinoma prognosis (ER, PR and ErbB2 receptors) were analyzed.</p> <p>Results</p> <p>All neoplastic breast tissues, either benign or malignant breast tissues, were nuclear immunoreactive for Fra-1-recognizing antibody. The pattern of Fra-1 expression by benign neoplastic cells was predominantly nuclear. However, the nuclear/cytoplasmic concomitant immunoreactivity was observed in all types of breast carcinomas. A clear shift in Fra-1 immunoreactivity, from an exclusively nuclear to a simultaneous nuclear and cytoplasmic localization was noticed in ~90% of breast carcinomas.</p> <p>Conclusion</p> <p>The overall expression, pattern and intensity of Fra-1 proteins were correlated with breast oncogenesis. Overexpression of Fra-1, leading to a persistent high cytoplasmic accumulation, may play a role in the process of breast carcinogenesis.</p>http://www.biomedcentral.com/1471-2407/6/298 |
| spellingShingle | Chen Liyong Zhang Yan Zhang Dong Song Santai Song Yuhua Qian Lu Shi Ming Zhao Huibin Jiang Zefei Guo Ning An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy BMC Cancer |
| title | An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy |
| title_full | An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy |
| title_fullStr | An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy |
| title_full_unstemmed | An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy |
| title_short | An association of a simultaneous nuclear and cytoplasmic localization of Fra-1 with breast malignancy |
| title_sort | association of a simultaneous nuclear and cytoplasmic localization of fra 1 with breast malignancy |
| url | http://www.biomedcentral.com/1471-2407/6/298 |
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