Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring
Background: Excessive supraventricular ectopic activity (ESVEA), defined as ≥720 premature atrial contractions (PAC) per day or any runs of ≥20 PACs, has been proposed as a surrogate marker for paroxysmal atrial fibrillation (PAF). Objective: We aimed to estimate the prognostic impact of ESVEA on th...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Heart Rhythm O2 |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666501821000817 |
| _version_ | 1819148719166062592 |
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| author | Bjørn Strøier Larsen, MD Mark Aplin, MD, PhD Olav Wendelboe Nielsen, MD, PhD, DMSc Maria Helena Dominguez Vall-Lamora, MD, PhD Nis Baun Høst, MD, PhD Ole Peter Kristiansen, MD, DMSc Hanne Kruuse Rasmusen, MD, PhD Ulla Davidsen, MD Finn Michael Karlsen, MD, PhD Søren Højberg, MD, PhD Ahmad Sajadieh, MD, PhD, DMSc |
| author_facet | Bjørn Strøier Larsen, MD Mark Aplin, MD, PhD Olav Wendelboe Nielsen, MD, PhD, DMSc Maria Helena Dominguez Vall-Lamora, MD, PhD Nis Baun Høst, MD, PhD Ole Peter Kristiansen, MD, DMSc Hanne Kruuse Rasmusen, MD, PhD Ulla Davidsen, MD Finn Michael Karlsen, MD, PhD Søren Højberg, MD, PhD Ahmad Sajadieh, MD, PhD, DMSc |
| author_sort | Bjørn Strøier Larsen, MD |
| collection | DOAJ |
| description | Background: Excessive supraventricular ectopic activity (ESVEA), defined as ≥720 premature atrial contractions (PAC) per day or any runs of ≥20 PACs, has been proposed as a surrogate marker for paroxysmal atrial fibrillation (PAF). Objective: We aimed to estimate the prognostic impact of ESVEA on the future development of PAF in consecutive patients referred to ambulatory cardiac monitoring. Methods: The cohort consists of a population with comorbidities referred to 48-hour ambulatory electrocardiogram aged 30–98 (n = 1316) between 2009 and 2011. After exclusion of known or current atrial fibrillation (AF) (n = 527) and patients with pacemakers (n = 7), 782 patients were included, with a median follow-up of 8.1 years. Events of incident AF and death were retrieved from patient records. Results: Mean age was 58.6 ± 15.5 years and 56.5% were women. A total of 101 patients had ESVEA at baseline (12.9%). During follow-up, 69 (8.9%) developed incidental AF. Twenty-three patients with ESVEA developed AF (23%). Incidence rate of AF in patients with and without ESVEA was 37.1/1000 person-years and 9.1 per 1000 person-years, respectively (P < .001). ESVEA was associated with incident AF after adjustment for potential confounders in Cox regression analysis (hazard ratio [HR]: 2.39; 95% confidence interval [CI]: 1.40–4.09) and in competing risk analysis with death as competing risk (subdistribution HR: 2.35; 95% CI: 1.30–4.17). Conclusion: ESVEA increases the risk of incident AF substantially in a population referred to ambulatory cardiac monitoring. |
| first_indexed | 2024-12-22T13:50:11Z |
| format | Article |
| id | doaj.art-d3857a77e2864f2aa77ee29be094b580 |
| institution | Directory Open Access Journal |
| issn | 2666-5018 |
| language | English |
| last_indexed | 2024-12-22T13:50:11Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heart Rhythm O2 |
| spelling | doaj.art-d3857a77e2864f2aa77ee29be094b5802022-12-21T18:23:41ZengElsevierHeart Rhythm O22666-50182021-06-0123231238Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoringBjørn Strøier Larsen, MD0Mark Aplin, MD, PhD1Olav Wendelboe Nielsen, MD, PhD, DMSc2Maria Helena Dominguez Vall-Lamora, MD, PhD3Nis Baun Høst, MD, PhD4Ole Peter Kristiansen, MD, DMSc5Hanne Kruuse Rasmusen, MD, PhD6Ulla Davidsen, MD7Finn Michael Karlsen, MD, PhD8Søren Højberg, MD, PhD9Ahmad Sajadieh, MD, PhD, DMSc10Address reprint requests and correspondence: Dr Bjørn Strøier Larsen, Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Bispebjerg Bakke 23, Copenhagen DK-2400, Denmark.; Department of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkDepartment of Cardiology, Copenhagen University Hospital of Bispebjerg, Copenhagen, DenmarkBackground: Excessive supraventricular ectopic activity (ESVEA), defined as ≥720 premature atrial contractions (PAC) per day or any runs of ≥20 PACs, has been proposed as a surrogate marker for paroxysmal atrial fibrillation (PAF). Objective: We aimed to estimate the prognostic impact of ESVEA on the future development of PAF in consecutive patients referred to ambulatory cardiac monitoring. Methods: The cohort consists of a population with comorbidities referred to 48-hour ambulatory electrocardiogram aged 30–98 (n = 1316) between 2009 and 2011. After exclusion of known or current atrial fibrillation (AF) (n = 527) and patients with pacemakers (n = 7), 782 patients were included, with a median follow-up of 8.1 years. Events of incident AF and death were retrieved from patient records. Results: Mean age was 58.6 ± 15.5 years and 56.5% were women. A total of 101 patients had ESVEA at baseline (12.9%). During follow-up, 69 (8.9%) developed incidental AF. Twenty-three patients with ESVEA developed AF (23%). Incidence rate of AF in patients with and without ESVEA was 37.1/1000 person-years and 9.1 per 1000 person-years, respectively (P < .001). ESVEA was associated with incident AF after adjustment for potential confounders in Cox regression analysis (hazard ratio [HR]: 2.39; 95% confidence interval [CI]: 1.40–4.09) and in competing risk analysis with death as competing risk (subdistribution HR: 2.35; 95% CI: 1.30–4.17). Conclusion: ESVEA increases the risk of incident AF substantially in a population referred to ambulatory cardiac monitoring.http://www.sciencedirect.com/science/article/pii/S2666501821000817Atrial fibrillationEpidemiologyPremature atrial contractionsRisk stratificationSurvival analysis |
| spellingShingle | Bjørn Strøier Larsen, MD Mark Aplin, MD, PhD Olav Wendelboe Nielsen, MD, PhD, DMSc Maria Helena Dominguez Vall-Lamora, MD, PhD Nis Baun Høst, MD, PhD Ole Peter Kristiansen, MD, DMSc Hanne Kruuse Rasmusen, MD, PhD Ulla Davidsen, MD Finn Michael Karlsen, MD, PhD Søren Højberg, MD, PhD Ahmad Sajadieh, MD, PhD, DMSc Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring Heart Rhythm O2 Atrial fibrillation Epidemiology Premature atrial contractions Risk stratification Survival analysis |
| title | Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring |
| title_full | Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring |
| title_fullStr | Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring |
| title_full_unstemmed | Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring |
| title_short | Excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring |
| title_sort | excessive supraventricular ectopic activity and risk of incident atrial fibrillation in a consecutive population referred to ambulatory cardiac monitoring |
| topic | Atrial fibrillation Epidemiology Premature atrial contractions Risk stratification Survival analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2666501821000817 |
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