Physiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties

Physiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties

A model-based framework is presented to predict monoclonal antibody (mAb) pharmacokinetics (PK) in humans based on in vitro measures of antibody physiochemical properties. A physiologically based pharmacokinetic (PBPK) model is used to explore the predictive potential of 14 in vitro assays designed...

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Bibliographic Details
Main Authors: Shihao Hu, Amita Datta-Mannan, David Z. D’Argenio
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:mAbs
Subjects:
FcRn interaction
nonspecific binding
antibody convective transport
two-pore theory
in vitro-in vivo prediction
PBPK model
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2022.2056944

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2022.2056944

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