Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI

Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI

(1) Background: The acidosis of the tumor micro-environment may have profound impact on cancer progression and on the efficacy of treatments. In the present study, we evaluated the impact of a treatment with UK-5099, a mitochondrial pyruvate carrier (MPC) inhibitor on tumor extracellular pH (pHe); (...

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Bibliographic Details
Main Authors: Chloé Buyse, Nicolas Joudiou, Cyril Corbet, Olivier Feron, Lionel Mignion, Julien Flament, Bernard Gallez
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
pH
acidosis
glycolysis
tumor
mitochondrial pyruvate carrier (MPC)
MRI
Online Access:https://www.mdpi.com/2072-6694/13/17/4278

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