Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells

PLK1 is a protein kinase that regulates mitosis and is both an important oncology drug target and a potential antitarget of drugs for the DNA damage response pathway or anti-infective host kinases. To expand the range of live cell NanoBRET target engagement assays to include PLK1, we developed an en...

Full description

Bibliographic Details
Main Authors: Xuan Yang, Jeffery L. Smith, Michael T. Beck, Jennifer M. Wilkinson, Ani Michaud, James D. Vasta, Matthew B. Robers, Timothy M. Willson
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
kinase
assay
drug
in cell
target engagement
Online Access:https://www.mdpi.com/1420-3049/28/7/2950

Similar Items

Similar Items