Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodies
Abstract Marek’s disease (MD) is a major disease of chickens induced by Marek’s disease virus (MDV) associated to lethal lymphomas. Current MD vaccines protect against lymphomas, but fail to prevent infection and shedding. The control of MDV shedding is crucial in order to eradicate this highly cont...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Veterinary Research |
| Online Access: | http://link.springer.com/article/10.1186/s13567-020-00749-1 |
| _version_ | 1818447423320621056 |
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| author | Sylvie Rémy Gilles Le Pape David Gourichon Yannick Gardin Caroline Denesvre |
| author_facet | Sylvie Rémy Gilles Le Pape David Gourichon Yannick Gardin Caroline Denesvre |
| author_sort | Sylvie Rémy |
| collection | DOAJ |
| description | Abstract Marek’s disease (MD) is a major disease of chickens induced by Marek’s disease virus (MDV) associated to lethal lymphomas. Current MD vaccines protect against lymphomas, but fail to prevent infection and shedding. The control of MDV shedding is crucial in order to eradicate this highly contagious virus. Like pathogenic MDV, MD vaccines infect the feather follicles of the skin before being shed into the environment. MD vaccines constitute excellent models to study virus interaction with feathers, the unique excretion source of these viruses. Herein we studied the viral persistence in feathers of a MD vaccine, the recombinant turkey herpesvirus (rHVT-ND). We report that most of the birds showed a persistent HVT infection of feathers over 41 weeks with moderate viral loads. Interestingly, 20% of the birds were identified as low HVT producers, among which six birds cleared the infection. Indeed, after week 14–26, these birds named controllers had undetectable HVT DNA in their feathers through week 41. All vaccinated birds developed antibodies to NDV, which lasted until week 41 in 95% of the birds, including the controllers. No correlation was found between HVT loads in feathers and NDV antibody titers over time. Interestingly, no HVT DNA was detected in the spleens of four controllers. This is the first description of chickens that durably cleared MD vaccine infection of feathers suggesting that control of Mardivirus shedding is achievable by the host. |
| first_indexed | 2024-12-14T20:03:23Z |
| format | Article |
| id | doaj.art-d391269193f440c2baeea3785f2671f2 |
| institution | Directory Open Access Journal |
| issn | 1297-9716 |
| language | English |
| last_indexed | 2024-12-14T20:03:23Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Veterinary Research |
| spelling | doaj.art-d391269193f440c2baeea3785f2671f22022-12-21T22:49:07ZengBMCVeterinary Research1297-97162020-02-0151111210.1186/s13567-020-00749-1Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodiesSylvie Rémy0Gilles Le Pape1David Gourichon2Yannick Gardin3Caroline Denesvre4Laboratoire de Biologie des Virus Aviaires, ISP, INRAE, Université ToursAnastatsPEAT, INRAECeva Santé AnimaleLaboratoire de Biologie des Virus Aviaires, ISP, INRAE, Université ToursAbstract Marek’s disease (MD) is a major disease of chickens induced by Marek’s disease virus (MDV) associated to lethal lymphomas. Current MD vaccines protect against lymphomas, but fail to prevent infection and shedding. The control of MDV shedding is crucial in order to eradicate this highly contagious virus. Like pathogenic MDV, MD vaccines infect the feather follicles of the skin before being shed into the environment. MD vaccines constitute excellent models to study virus interaction with feathers, the unique excretion source of these viruses. Herein we studied the viral persistence in feathers of a MD vaccine, the recombinant turkey herpesvirus (rHVT-ND). We report that most of the birds showed a persistent HVT infection of feathers over 41 weeks with moderate viral loads. Interestingly, 20% of the birds were identified as low HVT producers, among which six birds cleared the infection. Indeed, after week 14–26, these birds named controllers had undetectable HVT DNA in their feathers through week 41. All vaccinated birds developed antibodies to NDV, which lasted until week 41 in 95% of the birds, including the controllers. No correlation was found between HVT loads in feathers and NDV antibody titers over time. Interestingly, no HVT DNA was detected in the spleens of four controllers. This is the first description of chickens that durably cleared MD vaccine infection of feathers suggesting that control of Mardivirus shedding is achievable by the host.http://link.springer.com/article/10.1186/s13567-020-00749-1 |
| spellingShingle | Sylvie Rémy Gilles Le Pape David Gourichon Yannick Gardin Caroline Denesvre Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodies Veterinary Research |
| title | Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodies |
| title_full | Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodies |
| title_fullStr | Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodies |
| title_full_unstemmed | Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodies |
| title_short | Chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine-induced antibodies |
| title_sort | chickens can durably clear herpesvirus vaccine infection in feathers while still carrying vaccine induced antibodies |
| url | http://link.springer.com/article/10.1186/s13567-020-00749-1 |
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