Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literature
Sperm carries male genetic information, and flagella help move the sperm to reach oocytes. When the ultrastructure of the flagella is abnormal, the sperm is unable to reach the oocyte and achieve insemination. Multiple morphological abnormalities of sperm flagella (MMAF) is a relatively rare idiopat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.1034951/full |
| _version_ | 1797985127895138304 |
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| author | Jiaxiong Wang Weizhuo Wang Liyan Shen Aiyan Zheng Qingxia Meng Hong Li Shenmin Yang |
| author_facet | Jiaxiong Wang Weizhuo Wang Liyan Shen Aiyan Zheng Qingxia Meng Hong Li Shenmin Yang |
| author_sort | Jiaxiong Wang |
| collection | DOAJ |
| description | Sperm carries male genetic information, and flagella help move the sperm to reach oocytes. When the ultrastructure of the flagella is abnormal, the sperm is unable to reach the oocyte and achieve insemination. Multiple morphological abnormalities of sperm flagella (MMAF) is a relatively rare idiopathic condition that is mainly characterized by multiple defects in sperm flagella. In the last decade, with the development of high-throughput DNA sequencing approaches, many genes have been revealed to be related to MMAF. However, the differences in sperm phenotypes and reproductive outcomes in many cases are attributed to different pathogenic genes or different pathogenic mutations in the same gene. Here, we will review information about the various phenotypes resulting from different pathogenic genes, including sperm ultrastructure and encoding proteins with their location and functions as well as assisted reproductive technology (ART) outcomes. We will share our clinical detection and diagnosis experience to provide additional clinical views and broaden the understanding of this disease. |
| first_indexed | 2024-04-11T07:13:51Z |
| format | Article |
| id | doaj.art-d3933c150a33438f95cba4dd5b6da724 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-11T07:13:51Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-d3933c150a33438f95cba4dd5b6da7242022-12-22T04:38:05ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-11-011310.3389/fgene.2022.10349511034951Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literatureJiaxiong WangWeizhuo WangLiyan ShenAiyan ZhengQingxia MengHong LiShenmin YangSperm carries male genetic information, and flagella help move the sperm to reach oocytes. When the ultrastructure of the flagella is abnormal, the sperm is unable to reach the oocyte and achieve insemination. Multiple morphological abnormalities of sperm flagella (MMAF) is a relatively rare idiopathic condition that is mainly characterized by multiple defects in sperm flagella. In the last decade, with the development of high-throughput DNA sequencing approaches, many genes have been revealed to be related to MMAF. However, the differences in sperm phenotypes and reproductive outcomes in many cases are attributed to different pathogenic genes or different pathogenic mutations in the same gene. Here, we will review information about the various phenotypes resulting from different pathogenic genes, including sperm ultrastructure and encoding proteins with their location and functions as well as assisted reproductive technology (ART) outcomes. We will share our clinical detection and diagnosis experience to provide additional clinical views and broaden the understanding of this disease.https://www.frontiersin.org/articles/10.3389/fgene.2022.1034951/fullMMAFintracytoplasmic sperm injectionclinical detectiondiagnosisgenetic |
| spellingShingle | Jiaxiong Wang Weizhuo Wang Liyan Shen Aiyan Zheng Qingxia Meng Hong Li Shenmin Yang Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literature Frontiers in Genetics MMAF intracytoplasmic sperm injection clinical detection diagnosis genetic |
| title | Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literature |
| title_full | Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literature |
| title_fullStr | Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literature |
| title_full_unstemmed | Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literature |
| title_short | Clinical detection, diagnosis and treatment of morphological abnormalities of sperm flagella: A review of literature |
| title_sort | clinical detection diagnosis and treatment of morphological abnormalities of sperm flagella a review of literature |
| topic | MMAF intracytoplasmic sperm injection clinical detection diagnosis genetic |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.1034951/full |
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