Heart rate and blood pressure in male Ts65Dn mice: a model to investigate cardiovascular responses in Down syndrome

Abstract Down syndrome (Ds) is the most common chromosomal cause of intellectual disability that results from triplication of chromosome 21 genes. Lower blood pressure (BP) and heart rate (HR) in response to exercise and other stressors are prevalent in Ds, and are mediated by autonomic dysfunction....

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Bibliographic Details
Main Authors: Lara R. DeRuisseau, Candace N. Receno, Kevin S. Heffernan, Caitlin M. Cunningham
Format: Article
Language:English
Published: Wiley 2019-09-01
Series:Physiological Reports
Subjects:
Online Access:https://doi.org/10.14814/phy2.14205