The inverted U‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyte
Abstract Background The relationship between epinephrine and cancer can be dose‐dependent in in vivo study. Whether it is the same in human body still needs verification. Method We used frozen human pancreatic ductal adenocarcinoma (PDAC) tissues to detect epinephrine content and analyzed its relati...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-04-01
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| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.7164 |
| _version_ | 1797205668323655680 |
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| author | Bing‐Xue Li Xiao‐Cen Zhu Xia‐Xing Deng |
| author_facet | Bing‐Xue Li Xiao‐Cen Zhu Xia‐Xing Deng |
| author_sort | Bing‐Xue Li |
| collection | DOAJ |
| description | Abstract Background The relationship between epinephrine and cancer can be dose‐dependent in in vivo study. Whether it is the same in human body still needs verification. Method We used frozen human pancreatic ductal adenocarcinoma (PDAC) tissues to detect epinephrine content and analyzed its relationship with survival using the K‐M method and Cox regression. Disturbance of blood cell count and C‐reactive protein and identification of related potent intermediary factors were also analyzed. Results K‐M plot and Cox regression all showed the inverted U‐shaped relationship between epinephrine and PDAC survival. Lymphocyte adjustment can increase the HRs of epinephrine for PDAC death by >10%. Conclusion Epinephrine played an anti‐tumor or pro‐tumor effect depending on the specific concentration. Circulating lymphocyte count was elevated and might acted as a compensation pathway to reduce the pro‐tumor effect of epinephrine to PDAC. |
| first_indexed | 2024-04-24T08:54:47Z |
| format | Article |
| id | doaj.art-d39442c8b90044e9a35b3603f758d46d |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-24T08:54:47Z |
| publishDate | 2024-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-d39442c8b90044e9a35b3603f758d46d2024-04-16T08:48:34ZengWileyCancer Medicine2045-76342024-04-01137n/an/a10.1002/cam4.7164The inverted U‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyteBing‐Xue Li0Xiao‐Cen Zhu1Xia‐Xing Deng2Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai ChinaCore Facility of Basic Medical Sciences Shanghai Jiaotong University School of Medicine Shanghai ChinaDepartment of General Surgery, Pancreatic Disease Center, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai ChinaAbstract Background The relationship between epinephrine and cancer can be dose‐dependent in in vivo study. Whether it is the same in human body still needs verification. Method We used frozen human pancreatic ductal adenocarcinoma (PDAC) tissues to detect epinephrine content and analyzed its relationship with survival using the K‐M method and Cox regression. Disturbance of blood cell count and C‐reactive protein and identification of related potent intermediary factors were also analyzed. Results K‐M plot and Cox regression all showed the inverted U‐shaped relationship between epinephrine and PDAC survival. Lymphocyte adjustment can increase the HRs of epinephrine for PDAC death by >10%. Conclusion Epinephrine played an anti‐tumor or pro‐tumor effect depending on the specific concentration. Circulating lymphocyte count was elevated and might acted as a compensation pathway to reduce the pro‐tumor effect of epinephrine to PDAC.https://doi.org/10.1002/cam4.7164immunologypancreatic cancerprognostic factorsurvival |
| spellingShingle | Bing‐Xue Li Xiao‐Cen Zhu Xia‐Xing Deng The inverted U‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyte Cancer Medicine immunology pancreatic cancer prognostic factor survival |
| title | The inverted U‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyte |
| title_full | The inverted U‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyte |
| title_fullStr | The inverted U‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyte |
| title_full_unstemmed | The inverted U‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyte |
| title_short | The inverted U‐shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients' survival with compensation of lymphocyte |
| title_sort | inverted u shaped relationship between epinephrine and pancreatic ductal adenocarcinoma patients survival with compensation of lymphocyte |
| topic | immunology pancreatic cancer prognostic factor survival |
| url | https://doi.org/10.1002/cam4.7164 |
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