Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites.

Exposure to N-ethyl-N-nitrosourea in adult mice alters structural and functional integrity of neurogenic sites.

<h4>Background</h4>Previous studies have shown that prenatal exposure to the mutagen N-ethyl-N-nitrosourea (ENU), a N-nitroso compound (NOC) found in the environment, disrupts developmental neurogenesis and alters memory formation. Previously, we showed that postnatal ENU treatment induc...

Full description

Bibliographic Details
Main Authors:	Vivian Capilla-Gonzalez, Sara Gil-Perotin, Antonio Ferragud, Luis Bonet-Ponce, Juan Jose Canales, Jose Manuel Garcia-Verdugo
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2012-01-01
Series:	PLoS ONE
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22238669/?tool=EBI

Similar Items

N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels
by: Hrabé de Angelis Martin, et al.
Published: (2009-06-01)

Mutational Analysis of N-Ethyl-N-Nitrosourea (ENU) in the Fission Yeast Schizosaccharomyces pombe
by: Rafael Hoyos-Manchado, et al.
Published: (2020-03-01)

Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice
by: Lucienne Chatenoud, et al.
Published: (2022-06-01)

Spontaneous inflammatory pain model from a mouse line with <it>N</it>-ethyl-<it>N</it>-nitrosourea mutagenesis
by: Chen Tsung-Chieh, et al.
Published: (2012-05-01)

Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus.
by: Ming-Jen Lee, et al.
Published: (2009-11-01)

Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens.
by: Keays, D, et al.
Published: (2006)

Vanillic acid protects mortality and toxicity induced by N-ethyl-N-nitrosourea in mice; in vivo model of chronic lymphocytic leukemia
by: Ahmad Salimi, et al.
Published: (2024-06-01)

<i>Socrates:</i> A Novel N-Ethyl-N-nitrosourea-Induced Mouse Mutant with Audiogenic Epilepsy
by: Elena G. Varlamova, et al.
Published: (2023-12-01)

Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans
by: Omar A. Itani, et al.
Published: (2016-02-01)

An N-ethyl-N-nitrosourea (ENU) mutagenized mouse model for autosomal dominant non-syndromic kyphoscoliosis due to vertebral fusion
by: Esapa, C, et al.
Published: (2018)

An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria.
by: Silayuv E Bongfen, et al.
Published: (2012-01-01)

Alteration of serum biochemical parameters and urinalysis in Sprague Dawley rats administered with N-methyl-N-nitrosourea
by: Hakimi, M. K., et al.
Published: (2012)

An N-ethyl-N-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess.
by: Bentley, L, et al.
Published: (2014)

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models
by: Esapa, C, et al.
Published: (2015)

An N-ethyl-n-nitrosourea induced corticotropin-releasing hormone promoter mutation provides a mouse model for endogenous glucocorticoid excess
by: Bentley, L, et al.
Published: (2014)

N-ethyl-n-nitrosourea induced leukaemia in a mouse model through upregulation of vascular endothelial growth factor and evading apoptosis
by: Abdullahi, Aliyu, et al.
Published: (2020)

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models.
by: Christopher T Esapa, et al.
Published: (2015-01-01)

Effects of N-methyl-N-nitrosourea on seed germination of Stevia rebaudiana
by: Ahmad, Lyena Watty Zuraine, et al.
Published: (2019)

Effects of N-Methyl-N-Nitrosourea on seed germination of Stevia rebaudiana
by: Lyena Watty Zuraine Ahmad,, et al.
Published: (2019)

Antimutagenic components in Spatholobus suberectus Dunn against N-methyl-N-nitrosourea
by: Keiko Inami, et al.
Published: (2019-12-01)

An N-ethyl-N-Nitrosourea Mutagenesis Screen in Mice Reveals a Mutation in <i>Nuclear Respiratory Factor 1</i> (<i>Nrf1)</i> Altering the DNA Methylation State and Correct Embryonic Development
by: Maria Alba Sorolla, et al.
Published: (2021-07-01)

N-ethyl-N-nitrosourea-induced adaptor protein 2 sigma subunit 1 ( Ap2s1 ) mutations establish Ap2s1 loss-of-function mice
by: Gorvin, C, et al.
Published: (2017)

Genotoxic and chemopreventive potentials of ethanol leaves extract of Annona muricata on N-Ethyl-N-Nitrosourea-induced pro-leukaemia carcinogen in mice model by bone marrow micronucleus assay
by: Oluwaseyi Bamisaye, et al.
Published: (2022-12-01)

Short-term carcinogenicity study of N-methyl-N-nitrosourea in FVB-Trp53 heterozygous mice.
by: Na-Won Kim, et al.
Published: (2023-01-01)

Role of Oxidative Stress in Retinal Photoreceptor Cell Death in N-Methyl-N-nitrosourea–Treated Mice
by: Kazuhiro Tsuruma, et al.
Published: (2012-01-01)

Involvement of neuronal nitric oxide synthase in N-methyl-N-nitrosourea-induced retinal degeneration in mice
by: Yoshiki Koriyama, et al.
Published: (2015-03-01)

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis
by: Esapa, C, et al.
Published: (2012)

<i>N</i>-Ethyl-<i>n</i>-Nitrosourea Induced Leukaemia in a Mouse Model through Upregulation of Vascular Endothelial Growth Factor and Evading Apoptosis
by: Abdullahi Aliyu, et al.
Published: (2020-03-01)

A mouse with an N-Ethyl-N-nitrosourea (ENU) Induced Trp589Arg Galnt3 mutation represents a model for hyperphosphataemic familial tumoural calcinosis.
by: Christopher T Esapa, et al.
Published: (2012-01-01)

HSP70 cleavage-induced photoreceptor cell death caused by N-methyl-N-nitrosourea
by: Yoshiki Koriyama, et al.
Published: (2016-01-01)

o-Aminoazotoluene, 7,12-dimethylbenz[a]anthracene, and N-ethyl-N-nitrosourea, which are mutagenic but not carcinogenic in the colon, rapidly induce colonic tumors in mice with dextran sulfate sodium-induced colitis
by: Atsushi Hakura, et al.
Published: (2022-03-01)

Histopathological features of peripheral T-cell lymphoma in Sprague Dawley rats induced with N-methyl-N-nitrosourea
by: Al-Salih, Hutheyfa A. H., et al.
Published: (2011)

Lycium barbarum glycopeptide (wolfberry extract) slows N-methyl-N-nitrosourea-induced degradation of photoreceptors
by: Qihang Kong, et al.
Published: (2024-01-01)

The Influence of Physical Training on the Immune System of Rats during N-methyl-N-nitrosourea-Induced Carcinogenesis
by: Iwona Malicka, et al.
Published: (2022-10-01)

N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway
by: Saifang Fu, et al.
Published: (2022-07-01)

Preventive effect of Oenothera rosea on N-methyl-N-nitrosourea- (NMU) induced gastric cancer in rats
by: Almora-Pinedo Y, et al.
Published: (2017-12-01)

The reason for the amelioration of N-methyl-N-nitrosourea- induced retinitis pigmentosa in rats by hydrogen-rich saline
by: Wei-Ming Yan, et al.
Published: (2017-10-01)

N-Ethyl-N-Nitrosourea Induced Leukaemia in a Mouse Model: Protective Effect of Icaritin via Inhibition of IL-6/JAK2/STAT3 Pathway Causes Apoptosis
by: Hou X, et al.
Published: (2024-02-01)

Mice with an N-ethyl-N-nitrosourea (ENU) induced Tyr209Asn mutation in natriuretic peptide receptor 3 (NPR3) provide a model for kyphosis associated with activation of the MAPK signaling pathway
by: Esapa, C, et al.
Published: (2016)

Müller Cell Regulated Microglial Activation and Migration in Rats With N-Methyl-N-Nitrosourea-Induced Retinal Degeneration
by: Shuai Zhang, et al.
Published: (2018-12-01)