Influence of depressive symptoms on dopaminergic treatment of Parkinson’s disease
Introduction: Depressive symptoms are very common in patients with Parkinson’s disease and have a significant impact on the quality of life. Dopaminergic medication has been shown to have an influence on the development of depressive symptoms.Material and Methods: The present study analyzed two grou...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00188/full |
| _version_ | 1811273631392595968 |
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| author | Alexandru eHanganu Clotilde eDegroot Oury eMonchi Oury eMonchi Christophe eBedetti Béatriz eMejia-Constain Anne-Louise eLafontaine Anne-Louise eLafontaine Sylvain eChouinard Marie-Andrée eBruneau |
| author_facet | Alexandru eHanganu Clotilde eDegroot Oury eMonchi Oury eMonchi Christophe eBedetti Béatriz eMejia-Constain Anne-Louise eLafontaine Anne-Louise eLafontaine Sylvain eChouinard Marie-Andrée eBruneau |
| author_sort | Alexandru eHanganu |
| collection | DOAJ |
| description | Introduction: Depressive symptoms are very common in patients with Parkinson’s disease and have a significant impact on the quality of life. Dopaminergic medication has been shown to have an influence on the development of depressive symptoms.Material and Methods: The present study analyzed two groups of non-demented patients with Parkinson’s disease, with and without depressive symptoms, and reported the correlations between antiparkinsonian medication (specifically levodopa and dopaminergic agonists) with depressive symptoms.Results: A strong statistically significant positive correlation between levodopa dosages and the level of depressive symptoms has been revealed, suggesting that higher levodopa dosages correlate with a worsening of depressive status. No significant correlation was found with dopamine agonists.Discussion: The results of this study show that in patients with Parkinson’s disease, higher levodopa dosages correlate with worse depressive symptoms. From this point of view, Parkinson’s disease patients need to be better diagnosed with respect to depressive symptoms and need additional treatment adjustment when clinical manifestations of depression are present. Clinicians must be aware that dopaminergic drugs are not sufficient to alleviate depressive symptoms. |
| first_indexed | 2024-04-12T23:02:51Z |
| format | Article |
| id | doaj.art-d39806ce7ed54337a325bbc471323fa1 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T23:02:51Z |
| publishDate | 2014-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-d39806ce7ed54337a325bbc471323fa12022-12-22T03:13:00ZengFrontiers Media S.A.Frontiers in Neurology1664-22952014-09-01510.3389/fneur.2014.00188105585Influence of depressive symptoms on dopaminergic treatment of Parkinson’s diseaseAlexandru eHanganu0Clotilde eDegroot1Oury eMonchi2Oury eMonchi3Christophe eBedetti4Béatriz eMejia-Constain5Anne-Louise eLafontaine6Anne-Louise eLafontaine7Sylvain eChouinard8Marie-Andrée eBruneau9University of MontrealUniversity of MontrealUniversity of MontrealUniversity of MontrealHôpital du Sacré Coeur de MontréalUniversity of MontrealMontreal Neurological HospitalMcGill University Health CenterCentre Hospitalier de l'Université de MontréalUniversity of MontrealIntroduction: Depressive symptoms are very common in patients with Parkinson’s disease and have a significant impact on the quality of life. Dopaminergic medication has been shown to have an influence on the development of depressive symptoms.Material and Methods: The present study analyzed two groups of non-demented patients with Parkinson’s disease, with and without depressive symptoms, and reported the correlations between antiparkinsonian medication (specifically levodopa and dopaminergic agonists) with depressive symptoms.Results: A strong statistically significant positive correlation between levodopa dosages and the level of depressive symptoms has been revealed, suggesting that higher levodopa dosages correlate with a worsening of depressive status. No significant correlation was found with dopamine agonists.Discussion: The results of this study show that in patients with Parkinson’s disease, higher levodopa dosages correlate with worse depressive symptoms. From this point of view, Parkinson’s disease patients need to be better diagnosed with respect to depressive symptoms and need additional treatment adjustment when clinical manifestations of depression are present. Clinicians must be aware that dopaminergic drugs are not sufficient to alleviate depressive symptoms.http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00188/fullCognitionDopamine AgonistsL-DopaParkinson’s diseasedepressive symptoms |
| spellingShingle | Alexandru eHanganu Clotilde eDegroot Oury eMonchi Oury eMonchi Christophe eBedetti Béatriz eMejia-Constain Anne-Louise eLafontaine Anne-Louise eLafontaine Sylvain eChouinard Marie-Andrée eBruneau Influence of depressive symptoms on dopaminergic treatment of Parkinson’s disease Frontiers in Neurology Cognition Dopamine Agonists L-Dopa Parkinson’s disease depressive symptoms |
| title | Influence of depressive symptoms on dopaminergic treatment of Parkinson’s disease |
| title_full | Influence of depressive symptoms on dopaminergic treatment of Parkinson’s disease |
| title_fullStr | Influence of depressive symptoms on dopaminergic treatment of Parkinson’s disease |
| title_full_unstemmed | Influence of depressive symptoms on dopaminergic treatment of Parkinson’s disease |
| title_short | Influence of depressive symptoms on dopaminergic treatment of Parkinson’s disease |
| title_sort | influence of depressive symptoms on dopaminergic treatment of parkinson s disease |
| topic | Cognition Dopamine Agonists L-Dopa Parkinson’s disease depressive symptoms |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2014.00188/full |
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