Supplementation with β-carotene aids minimize inflammation in monosodium urate crystal- induced gouty arthritis in Wistar albino rats
Abstract Gout is a form of metabolic arthritis originated on grounds of increased accumulation of monosodium urate (MSU) crystals in joints. Current study focuses on anti-arthritic activities of β-carotene on MSU crystal-induced gouty arthritis rats in comparison with the non-steroidal anti-inflamma...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2022-04-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100549&tlng=en |
| _version_ | 1818126657947435008 |
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| author | Lavinya B Udhaya Aline Ubrewe Rutera K Ram Kumar N Sangeetha P Manisha Sabina Evan Prince |
| author_facet | Lavinya B Udhaya Aline Ubrewe Rutera K Ram Kumar N Sangeetha P Manisha Sabina Evan Prince |
| author_sort | Lavinya B Udhaya |
| collection | DOAJ |
| description | Abstract Gout is a form of metabolic arthritis originated on grounds of increased accumulation of monosodium urate (MSU) crystals in joints. Current study focuses on anti-arthritic activities of β-carotene on MSU crystal-induced gouty arthritis rats in comparison with the non-steroidal anti-inflammatory drug, indomethacin. The evaluation was done by taking into account paw oedema, lysosomal enzymes, anti-oxidant enzymes, lipid peroxidation, serum biochemical parameters (uric acid, creatinine), serum cytokines (TNF-α, IL-1β) and histopathological studies. After the induction of MSU crystals, the lysosomal enzymes were increased, antioxidant enzymes were reduced, lipid peroxidation increased and paw volume increased. β-carotene treated at a dose of 10 mg/kg of body weight stabilizes lysosomal enzymes, increases anti-oxidant enzymes, regulates lipid peroxidation and decreased paw volume. The drug β-carotene potentially influences anti-inflammatory effects in arthritic group which is evident from the reduction in the elevated levels of inflammatory cytokines, TNF-α and IL-1β. Current study is an evidence of anti-inflammatory and anti-oxidant effects of β-carotene against MSU-crystal induced gouty arthritis rats. |
| first_indexed | 2024-12-11T07:04:57Z |
| format | Article |
| id | doaj.art-d39cb783604f4c2fbb9a9415873f2d75 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-11T07:04:57Z |
| publishDate | 2022-04-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-d39cb783604f4c2fbb9a9415873f2d752022-12-22T01:16:31ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902022-04-015810.1590/s2175-97902020000118690Supplementation with β-carotene aids minimize inflammation in monosodium urate crystal- induced gouty arthritis in Wistar albino ratsLavinya B UdhayaAline Ubrewe RuteraK Ram KumarN SangeethaP ManishaSabina Evan Princehttps://orcid.org/0000-0003-2073-5971Abstract Gout is a form of metabolic arthritis originated on grounds of increased accumulation of monosodium urate (MSU) crystals in joints. Current study focuses on anti-arthritic activities of β-carotene on MSU crystal-induced gouty arthritis rats in comparison with the non-steroidal anti-inflammatory drug, indomethacin. The evaluation was done by taking into account paw oedema, lysosomal enzymes, anti-oxidant enzymes, lipid peroxidation, serum biochemical parameters (uric acid, creatinine), serum cytokines (TNF-α, IL-1β) and histopathological studies. After the induction of MSU crystals, the lysosomal enzymes were increased, antioxidant enzymes were reduced, lipid peroxidation increased and paw volume increased. β-carotene treated at a dose of 10 mg/kg of body weight stabilizes lysosomal enzymes, increases anti-oxidant enzymes, regulates lipid peroxidation and decreased paw volume. The drug β-carotene potentially influences anti-inflammatory effects in arthritic group which is evident from the reduction in the elevated levels of inflammatory cytokines, TNF-α and IL-1β. Current study is an evidence of anti-inflammatory and anti-oxidant effects of β-carotene against MSU-crystal induced gouty arthritis rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100549&tlng=enGouty arthritisInflammationβ-caroteneAntioxidantAnti-inflammatory |
| spellingShingle | Lavinya B Udhaya Aline Ubrewe Rutera K Ram Kumar N Sangeetha P Manisha Sabina Evan Prince Supplementation with β-carotene aids minimize inflammation in monosodium urate crystal- induced gouty arthritis in Wistar albino rats Brazilian Journal of Pharmaceutical Sciences Gouty arthritis Inflammation β-carotene Antioxidant Anti-inflammatory |
| title | Supplementation with β-carotene aids minimize inflammation in monosodium urate crystal- induced gouty arthritis in Wistar albino rats |
| title_full | Supplementation with β-carotene aids minimize inflammation in monosodium urate crystal- induced gouty arthritis in Wistar albino rats |
| title_fullStr | Supplementation with β-carotene aids minimize inflammation in monosodium urate crystal- induced gouty arthritis in Wistar albino rats |
| title_full_unstemmed | Supplementation with β-carotene aids minimize inflammation in monosodium urate crystal- induced gouty arthritis in Wistar albino rats |
| title_short | Supplementation with β-carotene aids minimize inflammation in monosodium urate crystal- induced gouty arthritis in Wistar albino rats |
| title_sort | supplementation with β carotene aids minimize inflammation in monosodium urate crystal induced gouty arthritis in wistar albino rats |
| topic | Gouty arthritis Inflammation β-carotene Antioxidant Anti-inflammatory |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100549&tlng=en |
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