Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study
BackgroundJuvenile idiopathic arthritis (JIA) is a chronic autoimmune disease characterized by destructive and inflammatory damage to the joints. The aim in this study was to compare vitamin D levels between children and adolescents, 1–18 years of age, with juvenile idiopathic arthritis (JIA) and a...
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.915943/full |
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| author | Elena I. Kondratyeva Elena I. Kondratyeva Nuriniso D. Odinaeva Leonid Ya Klimov Nadeshda S. Podchernyaeva Natalya I. Ilenkova Svetlana V. Dolbnya Elena K. Zhekaite Elena K. Zhekaite Victoria A. Kuryaninova Yuliya V. Kotova Margarita I. Tikhaya Elena P. Shitkovskaya Liubov V. Bychina Tamara G. Drepa Aisa E. Zodbinova Yuliya L. Melyanovskaya Yuliya L. Melyanovskaya Nika V. Petrova Elena V. Loshkova Sergei I. Kutsev |
| author_facet | Elena I. Kondratyeva Elena I. Kondratyeva Nuriniso D. Odinaeva Leonid Ya Klimov Nadeshda S. Podchernyaeva Natalya I. Ilenkova Svetlana V. Dolbnya Elena K. Zhekaite Elena K. Zhekaite Victoria A. Kuryaninova Yuliya V. Kotova Margarita I. Tikhaya Elena P. Shitkovskaya Liubov V. Bychina Tamara G. Drepa Aisa E. Zodbinova Yuliya L. Melyanovskaya Yuliya L. Melyanovskaya Nika V. Petrova Elena V. Loshkova Sergei I. Kutsev |
| author_sort | Elena I. Kondratyeva |
| collection | DOAJ |
| description | BackgroundJuvenile idiopathic arthritis (JIA) is a chronic autoimmune disease characterized by destructive and inflammatory damage to the joints. The aim in this study was to compare vitamin D levels between children and adolescents, 1–18 years of age, with juvenile idiopathic arthritis (JIA) and a health control group of peers. We considered effects of endogenous, exogenous, and genetic factors on measured differences in vitamin D levels among children with JIA.MethodsOur findings are based on a study sample of 150 patients with various variants of JIA and 277 healthy children. The blood level of vitamin D was assessed by calcidiol level. The following factors were included in our analysis: age and sex; level of insolation in three regions of country (center, south, north); assessment of dietary intake of vitamin D; effect of prophylactic doses of cholecalciferol; a relationship between the TaqI, FokI, and BsmI polymorphisms of the VDR gene and serum 25(OH)D concentration.ResultsWe identified a high frequency of low vitamin D among children with JIA, prevalence of 66%, with the medial level of vitamin D being within the range of “insufficient” vitamin D. We also show that the dietary intake of vitamin D by children with JIA is well below expected norms, and that prophylactic doses of vitamin D supplementation (cholecalciferol) at a dose of 500–1,000 IU/day and 1,500–2,000 IU/day do not meet the vitamin D needs of children with JIA. Of importance, we show that vitamin D levels among children with JIA are not affected by clinical therapies to manage the disease nor by the present of VDR genetic variants.ConclusionProphylactic administration of cholecalciferol and season of year play a determining role in the development of vitamin D deficiency and insufficiency. |
| first_indexed | 2024-04-13T10:24:21Z |
| format | Article |
| id | doaj.art-d39d1a95cdf1444780a67751f76a6569 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-13T10:24:21Z |
| publishDate | 2022-07-01 |
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| series | Frontiers in Pediatrics |
| spelling | doaj.art-d39d1a95cdf1444780a67751f76a65692022-12-22T02:50:23ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-07-011010.3389/fped.2022.915943915943Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative StudyElena I. Kondratyeva0Elena I. Kondratyeva1Nuriniso D. Odinaeva2Leonid Ya Klimov3Nadeshda S. Podchernyaeva4Natalya I. Ilenkova5Svetlana V. Dolbnya6Elena K. Zhekaite7Elena K. Zhekaite8Victoria A. Kuryaninova9Yuliya V. Kotova10Margarita I. Tikhaya11Elena P. Shitkovskaya12Liubov V. Bychina13Tamara G. Drepa14Aisa E. Zodbinova15Yuliya L. Melyanovskaya16Yuliya L. Melyanovskaya17Nika V. Petrova18Elena V. Loshkova19Sergei I. Kutsev20Research Centre for Medical Genetics, Moscow, RussiaResearch Clinical Institute for Childhood of the Moscow Region, Moscow, RussiaResearch Clinical Institute for Childhood of the Moscow Region, Moscow, RussiaStavropol State Medical University, Stavropol, RussiaSechenov University, Moscow, RussiaKrasnoyarsk State Medical University Named After Professor V. F. Voino-Yasenetsky, Krasnoyarsk, RussiaStavropol State Medical University, Stavropol, RussiaResearch Centre for Medical Genetics, Moscow, RussiaResearch Clinical Institute for Childhood of the Moscow Region, Moscow, RussiaStavropol State Medical University, Stavropol, RussiaResearch Clinical Institute for Childhood of the Moscow Region, Moscow, RussiaSechenov University, Moscow, RussiaKrasnoyarsk State Medical University Named After Professor V. F. Voino-Yasenetsky, Krasnoyarsk, RussiaKrasnoyarsk State Medical University Named After Professor V. F. Voino-Yasenetsky, Krasnoyarsk, RussiaStavropol State Medical University, Stavropol, RussiaResearch Centre for Medical Genetics, Moscow, RussiaResearch Centre for Medical Genetics, Moscow, RussiaResearch Clinical Institute for Childhood of the Moscow Region, Moscow, RussiaResearch Centre for Medical Genetics, Moscow, RussiaResearch Clinical Institute for Childhood of the Moscow Region, Moscow, RussiaResearch Centre for Medical Genetics, Moscow, RussiaBackgroundJuvenile idiopathic arthritis (JIA) is a chronic autoimmune disease characterized by destructive and inflammatory damage to the joints. The aim in this study was to compare vitamin D levels between children and adolescents, 1–18 years of age, with juvenile idiopathic arthritis (JIA) and a health control group of peers. We considered effects of endogenous, exogenous, and genetic factors on measured differences in vitamin D levels among children with JIA.MethodsOur findings are based on a study sample of 150 patients with various variants of JIA and 277 healthy children. The blood level of vitamin D was assessed by calcidiol level. The following factors were included in our analysis: age and sex; level of insolation in three regions of country (center, south, north); assessment of dietary intake of vitamin D; effect of prophylactic doses of cholecalciferol; a relationship between the TaqI, FokI, and BsmI polymorphisms of the VDR gene and serum 25(OH)D concentration.ResultsWe identified a high frequency of low vitamin D among children with JIA, prevalence of 66%, with the medial level of vitamin D being within the range of “insufficient” vitamin D. We also show that the dietary intake of vitamin D by children with JIA is well below expected norms, and that prophylactic doses of vitamin D supplementation (cholecalciferol) at a dose of 500–1,000 IU/day and 1,500–2,000 IU/day do not meet the vitamin D needs of children with JIA. Of importance, we show that vitamin D levels among children with JIA are not affected by clinical therapies to manage the disease nor by the present of VDR genetic variants.ConclusionProphylactic administration of cholecalciferol and season of year play a determining role in the development of vitamin D deficiency and insufficiency.https://www.frontiersin.org/articles/10.3389/fped.2022.915943/fullvitamin D deficiencyjuvenile idiopathic arthritisseasons of the yeargenotypesVDR gene |
| spellingShingle | Elena I. Kondratyeva Elena I. Kondratyeva Nuriniso D. Odinaeva Leonid Ya Klimov Nadeshda S. Podchernyaeva Natalya I. Ilenkova Svetlana V. Dolbnya Elena K. Zhekaite Elena K. Zhekaite Victoria A. Kuryaninova Yuliya V. Kotova Margarita I. Tikhaya Elena P. Shitkovskaya Liubov V. Bychina Tamara G. Drepa Aisa E. Zodbinova Yuliya L. Melyanovskaya Yuliya L. Melyanovskaya Nika V. Petrova Elena V. Loshkova Sergei I. Kutsev Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study Frontiers in Pediatrics vitamin D deficiency juvenile idiopathic arthritis seasons of the year genotypes VDR gene |
| title | Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study |
| title_full | Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study |
| title_fullStr | Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study |
| title_full_unstemmed | Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study |
| title_short | Vitamin D Status Among Children With Juvenile Idiopathic Arthritis: A Multicenter Prospective, Non-randomized, Comparative Study |
| title_sort | vitamin d status among children with juvenile idiopathic arthritis a multicenter prospective non randomized comparative study |
| topic | vitamin D deficiency juvenile idiopathic arthritis seasons of the year genotypes VDR gene |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.915943/full |
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