Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinoma
Cancer/testis antigens (CTAs) are reproductive tissue-restricted genes, frequently ectopic expressed in tumors. CTA genes associate with a poor prognosis in some solid tumors, due to their potential roles in the tumorigenesis and progression. However, whether CTAs relate with hepatocellular carcinom...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023004760 |
| _version_ | 1797852008979365888 |
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| author | Yingyu Xu Xin Xu Xiaojian Ni Jiaomeng Pan MaoPei Chen Youpei Lin Zhiying Zhao Lan Zhang Ningling Ge Guohe Song Juan Zhang |
| author_facet | Yingyu Xu Xin Xu Xiaojian Ni Jiaomeng Pan MaoPei Chen Youpei Lin Zhiying Zhao Lan Zhang Ningling Ge Guohe Song Juan Zhang |
| author_sort | Yingyu Xu |
| collection | DOAJ |
| description | Cancer/testis antigens (CTAs) are reproductive tissue-restricted genes, frequently ectopic expressed in tumors. CTA genes associate with a poor prognosis in some solid tumors, due to their potential roles in the tumorigenesis and progression. However, whether CTAs relate with hepatocellular carcinoma (HCC) remains unclear. In this study, the prognostic signatures based on CTA genes were investigated and validated in three cohorts including Chinese HCC patients with hepatitis B virus infection (CHCC-HBV), International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) cohorts. Univariate, LASSO, and multivariate Cox regression analyses were used to screen prognostic genes and develop the prognostic gene signature. A prognosis model was established with six CTA genes (SSX1, CTCFL, OIP5, CEP55, NOL4, and TPPP2) in CHCC-HBV cohort, and further validated in the ICGC and TCGA cohorts. The CTA signature was an essential prognostic predictor independent of other clinical pathological factors. High-risk group exhibited up-regulated cell cycle-related and tumor-related pathways and more M0 macrophage, activated mast cell, activated memory CD4+ T cell, and memory B cell infiltration. Furthermore, CTA signature correlated with the sensitivity to multiple chemotherapy drugs. Our results highlighted that the CTA gene profiling was a prognostic assessment tool for HCC patients. |
| first_indexed | 2024-04-09T19:26:00Z |
| format | Article |
| id | doaj.art-d39f1e1ef035452ea6f50f10c3abfd7a |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:26:00Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d39f1e1ef035452ea6f50f10c3abfd7a2023-04-05T08:15:26ZengElsevierHeliyon2405-84402023-03-0193e13269Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinomaYingyu Xu0Xin Xu1Xiaojian Ni2Jiaomeng Pan3MaoPei Chen4Youpei Lin5Zhiying Zhao6Lan Zhang7Ningling Ge8Guohe Song9Juan Zhang10Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, ChinaLiver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, ChinaDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, ChinaLiver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, ChinaLiver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, ChinaLiver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, ChinaLiver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, ChinaLiver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, ChinaLiver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, ChinaLiver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China; Corresponding author.Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China; Corresponding author.Cancer/testis antigens (CTAs) are reproductive tissue-restricted genes, frequently ectopic expressed in tumors. CTA genes associate with a poor prognosis in some solid tumors, due to their potential roles in the tumorigenesis and progression. However, whether CTAs relate with hepatocellular carcinoma (HCC) remains unclear. In this study, the prognostic signatures based on CTA genes were investigated and validated in three cohorts including Chinese HCC patients with hepatitis B virus infection (CHCC-HBV), International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) cohorts. Univariate, LASSO, and multivariate Cox regression analyses were used to screen prognostic genes and develop the prognostic gene signature. A prognosis model was established with six CTA genes (SSX1, CTCFL, OIP5, CEP55, NOL4, and TPPP2) in CHCC-HBV cohort, and further validated in the ICGC and TCGA cohorts. The CTA signature was an essential prognostic predictor independent of other clinical pathological factors. High-risk group exhibited up-regulated cell cycle-related and tumor-related pathways and more M0 macrophage, activated mast cell, activated memory CD4+ T cell, and memory B cell infiltration. Furthermore, CTA signature correlated with the sensitivity to multiple chemotherapy drugs. Our results highlighted that the CTA gene profiling was a prognostic assessment tool for HCC patients.http://www.sciencedirect.com/science/article/pii/S2405844023004760Hepatocellular carcinomaCancer-testis antigensBioinformaticsRisk scorePrognosis |
| spellingShingle | Yingyu Xu Xin Xu Xiaojian Ni Jiaomeng Pan MaoPei Chen Youpei Lin Zhiying Zhao Lan Zhang Ningling Ge Guohe Song Juan Zhang Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinoma Heliyon Hepatocellular carcinoma Cancer-testis antigens Bioinformatics Risk score Prognosis |
| title | Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinoma |
| title_full | Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinoma |
| title_fullStr | Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinoma |
| title_full_unstemmed | Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinoma |
| title_short | Gene-based cancer-testis antigens as prognostic indicators in hepatocellular carcinoma |
| title_sort | gene based cancer testis antigens as prognostic indicators in hepatocellular carcinoma |
| topic | Hepatocellular carcinoma Cancer-testis antigens Bioinformatics Risk score Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023004760 |
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