Acute pericarditis due to pegylated interferon alpha therapy for chronic HCV hepatitis - Case report
<p>Abstract</p> <p>Background</p> <p>Cardio toxicity due to interferon therapy was reported only in small case series or case reports. The most frequent cardiac adverse effects related to interferon are arrhythmias and ischemic manifestations. The cardiomyopathy and per...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-03-01
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| Series: | BMC Gastroenterology |
| Online Access: | http://www.biomedcentral.com/1471-230X/11/30 |
| _version_ | 1818114703221587968 |
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| author | Gliga Smaranda Arama Victoria Popescu Cristina |
| author_facet | Gliga Smaranda Arama Victoria Popescu Cristina |
| author_sort | Gliga Smaranda |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Cardio toxicity due to interferon therapy was reported only in small case series or case reports. The most frequent cardiac adverse effects related to interferon are arrhythmias and ischemic manifestations. The cardiomyopathy and pericarditis are rare but can be life threatening. The predisposing factors for interferon cardio toxicity were described only for ischemic manifestations and arrhythmias.</p> <p>Case presentation</p> <p>The authors report a case of pericarditis due to alpha interferon therapy for chronic hepatitis C, in a young woman without previous cardiac pathology. The clinical manifestations started during the 7-th month of interferon treatment. The cessation of interferon was necessary. After interferon discontinuation the patient recovered, with complete resolution of pericarditis. The patient scored 9 points on the Naranjo ADR probability scale, indicating a very probable association between pericarditis and interferon administration.</p> <p>Conclusion</p> <p>If a patient receiving interferon therapy complains of chest pain of sudden onset, a cardiac ultrasound should be performed in order to rule out pericarditis. We point out the possibility of an infrequent but severe adverse effect of interferon therapy.</p> |
| first_indexed | 2024-12-11T03:54:56Z |
| format | Article |
| id | doaj.art-d39ff4972b2645fa87ba5d442e6ba598 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-11T03:54:56Z |
| publishDate | 2011-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-d39ff4972b2645fa87ba5d442e6ba5982022-12-22T01:21:49ZengBMCBMC Gastroenterology1471-230X2011-03-011113010.1186/1471-230X-11-30Acute pericarditis due to pegylated interferon alpha therapy for chronic HCV hepatitis - Case reportGliga SmarandaArama VictoriaPopescu Cristina<p>Abstract</p> <p>Background</p> <p>Cardio toxicity due to interferon therapy was reported only in small case series or case reports. The most frequent cardiac adverse effects related to interferon are arrhythmias and ischemic manifestations. The cardiomyopathy and pericarditis are rare but can be life threatening. The predisposing factors for interferon cardio toxicity were described only for ischemic manifestations and arrhythmias.</p> <p>Case presentation</p> <p>The authors report a case of pericarditis due to alpha interferon therapy for chronic hepatitis C, in a young woman without previous cardiac pathology. The clinical manifestations started during the 7-th month of interferon treatment. The cessation of interferon was necessary. After interferon discontinuation the patient recovered, with complete resolution of pericarditis. The patient scored 9 points on the Naranjo ADR probability scale, indicating a very probable association between pericarditis and interferon administration.</p> <p>Conclusion</p> <p>If a patient receiving interferon therapy complains of chest pain of sudden onset, a cardiac ultrasound should be performed in order to rule out pericarditis. We point out the possibility of an infrequent but severe adverse effect of interferon therapy.</p>http://www.biomedcentral.com/1471-230X/11/30 |
| spellingShingle | Gliga Smaranda Arama Victoria Popescu Cristina Acute pericarditis due to pegylated interferon alpha therapy for chronic HCV hepatitis - Case report BMC Gastroenterology |
| title | Acute pericarditis due to pegylated interferon alpha therapy for chronic HCV hepatitis - Case report |
| title_full | Acute pericarditis due to pegylated interferon alpha therapy for chronic HCV hepatitis - Case report |
| title_fullStr | Acute pericarditis due to pegylated interferon alpha therapy for chronic HCV hepatitis - Case report |
| title_full_unstemmed | Acute pericarditis due to pegylated interferon alpha therapy for chronic HCV hepatitis - Case report |
| title_short | Acute pericarditis due to pegylated interferon alpha therapy for chronic HCV hepatitis - Case report |
| title_sort | acute pericarditis due to pegylated interferon alpha therapy for chronic hcv hepatitis case report |
| url | http://www.biomedcentral.com/1471-230X/11/30 |
| work_keys_str_mv | AT gligasmaranda acutepericarditisduetopegylatedinterferonalphatherapyforchronichcvhepatitiscasereport AT aramavictoria acutepericarditisduetopegylatedinterferonalphatherapyforchronichcvhepatitiscasereport AT popescucristina acutepericarditisduetopegylatedinterferonalphatherapyforchronichcvhepatitiscasereport |