Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study
Abstract Although some studies conducted about the risk of cholecystectomy and cardiovascular disease, there was a limit to explaining the relationship. We investigated the short-term and long-term relationship between cholecystectomy and cardiovascular disease, and evidence using the elements of th...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-53161-6 |
| _version_ | 1797274829840187392 |
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| author | Sangwoo Park Seogsong Jeong Sun Jae Park Jihun Song Sung Min Kim Jooyoung Chang Seulggie Choi Yoosun Cho Yun Hwan Oh Ji Soo Kim Young Jun Park Joung Sik Son Joseph C. Ahn Sang Min Park |
| author_facet | Sangwoo Park Seogsong Jeong Sun Jae Park Jihun Song Sung Min Kim Jooyoung Chang Seulggie Choi Yoosun Cho Yun Hwan Oh Ji Soo Kim Young Jun Park Joung Sik Son Joseph C. Ahn Sang Min Park |
| author_sort | Sangwoo Park |
| collection | DOAJ |
| description | Abstract Although some studies conducted about the risk of cholecystectomy and cardiovascular disease, there was a limit to explaining the relationship. We investigated the short-term and long-term relationship between cholecystectomy and cardiovascular disease, and evidence using the elements of the metabolic index as an intermediate step. It was a retrospective cohort study and we used the National Health Insurance Service database of South Korea between 2002 and 2015. Finally, 5,210 patients who underwent cholecystectomy and 49,457 at 1:10 age and gender-matched controls of subjects were collected. The main results was estimated by Multivariate Cox proportional hazard regression to calculate the hazard ratio (HR) with 95% confidence interval (CI) for risk of cardiovascular disease after cholecystectomy. Regarding short-term effects of cholecystectomy, increased risk of cardiovascular disease (aHR 1.35, 95% CI 1.15–1.58) and coronary heart disease (aHR 1.77, 95% CI 1.44–2.16) were similarly seen within 2 years of surgery. When analyzing the change in metabolic risk factors, cholecystectomy was associated with a change in systolic blood pressure (adjusted mean [aMean]: 1.51, 95% CI: [− 1.50 to − 4.51]), total cholesterol (aMean − 14.14, [− 20.33 to 7.95]) and body mass index (aMean − 0.13, [− 0.37 to 0.11]). Cholecystectomy patients had elevated risk of cardiovascular disease in the short-term, possibly due to the characteristics of the patient before surgery. The association of cholecystectomy and cardiovascular disease has decreased after 2 years in patients who underwent cholecystectomy, suggesting that because of improvement of metabolic health, cholecystectomy-associated elevation of cardiovascular disease risk may be ameliorated 2 years after cholecystectomy. |
| first_indexed | 2024-03-07T15:03:43Z |
| format | Article |
| id | doaj.art-d3a0c9acc2a541dba0c058f365fab387 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:03:43Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d3a0c9acc2a541dba0c058f365fab3872024-03-05T19:00:15ZengNature PortfolioScientific Reports2045-23222024-02-0114111010.1038/s41598-024-53161-6Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort studySangwoo Park0Seogsong Jeong1Sun Jae Park2Jihun Song3Sung Min Kim4Jooyoung Chang5Seulggie Choi6Yoosun Cho7Yun Hwan Oh8Ji Soo Kim9Young Jun Park10Joung Sik Son11Joseph C. Ahn12Sang Min Park13Department of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Biomedical Informatics, CHA University School of MedicineDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Biomedical Sciences, Seoul National University Graduate SchoolDepartment of Internal Medicine, Seoul National University HospitalTotal Healthcare Center, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan UniversityDepartment of Family Medicine, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of MedicineInternational Healthcare Center, Seoul National University HospitalMedical Research Center, Genomic Medicine Institute, Seoul National University College of MedicineDepartment of Family Medicine, Korea University Guro HospitalDivision of Gastroenterology and Hepatology, Mayo ClinicDepartment of Biomedical Sciences, Seoul National University Graduate SchoolAbstract Although some studies conducted about the risk of cholecystectomy and cardiovascular disease, there was a limit to explaining the relationship. We investigated the short-term and long-term relationship between cholecystectomy and cardiovascular disease, and evidence using the elements of the metabolic index as an intermediate step. It was a retrospective cohort study and we used the National Health Insurance Service database of South Korea between 2002 and 2015. Finally, 5,210 patients who underwent cholecystectomy and 49,457 at 1:10 age and gender-matched controls of subjects were collected. The main results was estimated by Multivariate Cox proportional hazard regression to calculate the hazard ratio (HR) with 95% confidence interval (CI) for risk of cardiovascular disease after cholecystectomy. Regarding short-term effects of cholecystectomy, increased risk of cardiovascular disease (aHR 1.35, 95% CI 1.15–1.58) and coronary heart disease (aHR 1.77, 95% CI 1.44–2.16) were similarly seen within 2 years of surgery. When analyzing the change in metabolic risk factors, cholecystectomy was associated with a change in systolic blood pressure (adjusted mean [aMean]: 1.51, 95% CI: [− 1.50 to − 4.51]), total cholesterol (aMean − 14.14, [− 20.33 to 7.95]) and body mass index (aMean − 0.13, [− 0.37 to 0.11]). Cholecystectomy patients had elevated risk of cardiovascular disease in the short-term, possibly due to the characteristics of the patient before surgery. The association of cholecystectomy and cardiovascular disease has decreased after 2 years in patients who underwent cholecystectomy, suggesting that because of improvement of metabolic health, cholecystectomy-associated elevation of cardiovascular disease risk may be ameliorated 2 years after cholecystectomy.https://doi.org/10.1038/s41598-024-53161-6 |
| spellingShingle | Sangwoo Park Seogsong Jeong Sun Jae Park Jihun Song Sung Min Kim Jooyoung Chang Seulggie Choi Yoosun Cho Yun Hwan Oh Ji Soo Kim Young Jun Park Joung Sik Son Joseph C. Ahn Sang Min Park Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study Scientific Reports |
| title | Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study |
| title_full | Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study |
| title_fullStr | Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study |
| title_full_unstemmed | Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study |
| title_short | Associations of cholecystectomy with metabolic health changes and incident cardiovascular disease: a retrospective cohort study |
| title_sort | associations of cholecystectomy with metabolic health changes and incident cardiovascular disease a retrospective cohort study |
| url | https://doi.org/10.1038/s41598-024-53161-6 |
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