Within subject, double blind, examination of opioid sensitivity in participant-reported, observed, physiologic, and analgesic outcomes
Background: Inter-individual differences in opioid sensitivity may underlie different opioid risk profiles but have often been researched in persons who have current or past opioid use disorder or physical dependence. This study examined how opioid sensitivity manifests across various assessments of...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Drug and Alcohol Dependence Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772724623000586 |
| _version_ | 1827815994062536704 |
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| author | Caitlyn J. Durgin Andrew S. Huhn Cecilia L. Bergeria Patrick H. Finan Claudia M. Campbell Denis G. Antoine Kelly E. Dunn |
| author_facet | Caitlyn J. Durgin Andrew S. Huhn Cecilia L. Bergeria Patrick H. Finan Claudia M. Campbell Denis G. Antoine Kelly E. Dunn |
| author_sort | Caitlyn J. Durgin |
| collection | DOAJ |
| description | Background: Inter-individual differences in opioid sensitivity may underlie different opioid risk profiles but have often been researched in persons who have current or past opioid use disorder or physical dependence. This study examined how opioid sensitivity manifests across various assessments of opioid effects in a primarily opioid-naïve population. Procedures: Data were harmonized from two within-subject, double-blind trials wherein healthy participants (N = 123) received placebo and 4 mg oral hydromorphone. Demographics, self-report ratings, observer ratings, physiological, and cold pressor measures were collected. Participants were categorized as being responsive or nonresponsive to the opioid dose tested and compared using mixed-models, Pearson product correlations, and paired t-tests. Findings: Participants were 49.6% female, mean 33.0 (SD=9.3) years old, and 44.7% Black/African American and 41.5% White, with 89.4% reporting no prior exposure to opioids. Within-subject sensitivity to opioids varied depending on the measure. One in five participants did not respond subjectively to the 4 mg hydromorphone dose based on their “Drug Effects” rating. Persons who were responsive showed more evidence of drug-dependent effects than did persons who were not responsive on ratings of Bad Effects (p= .03), feeling High (p= .01), Nausea (p= .03), pupil diameter (p< 0.01), and on the circular lights task (p< 0.001). Conclusions: This study provides initial evidence that the experience of opioids may be domain specific. Data suggest potentially clinically meaningful differences exist regarding opioid response patterns, evident following one dose among opioid inexperienced individuals. |
| first_indexed | 2024-03-12T00:08:35Z |
| format | Article |
| id | doaj.art-d3a1a58b798c4e5f9572a826c1abcfad |
| institution | Directory Open Access Journal |
| issn | 2772-7246 |
| language | English |
| last_indexed | 2024-03-12T00:08:35Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Drug and Alcohol Dependence Reports |
| spelling | doaj.art-d3a1a58b798c4e5f9572a826c1abcfad2023-09-16T05:32:05ZengElsevierDrug and Alcohol Dependence Reports2772-72462023-09-018100188Within subject, double blind, examination of opioid sensitivity in participant-reported, observed, physiologic, and analgesic outcomesCaitlyn J. Durgin0Andrew S. Huhn1Cecilia L. Bergeria2Patrick H. Finan3Claudia M. Campbell4Denis G. Antoine5Kelly E. Dunn6Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr, Baltimore MD 21224, USADepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr, Baltimore MD 21224, USADepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr, Baltimore MD 21224, USADepartment of Anesthesiology, University of Virginia, Charlottesville, VA, USADepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr, Baltimore MD 21224, USADepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr, Baltimore MD 21224, USADepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr, Baltimore MD 21224, USA; Corresponding author.Background: Inter-individual differences in opioid sensitivity may underlie different opioid risk profiles but have often been researched in persons who have current or past opioid use disorder or physical dependence. This study examined how opioid sensitivity manifests across various assessments of opioid effects in a primarily opioid-naïve population. Procedures: Data were harmonized from two within-subject, double-blind trials wherein healthy participants (N = 123) received placebo and 4 mg oral hydromorphone. Demographics, self-report ratings, observer ratings, physiological, and cold pressor measures were collected. Participants were categorized as being responsive or nonresponsive to the opioid dose tested and compared using mixed-models, Pearson product correlations, and paired t-tests. Findings: Participants were 49.6% female, mean 33.0 (SD=9.3) years old, and 44.7% Black/African American and 41.5% White, with 89.4% reporting no prior exposure to opioids. Within-subject sensitivity to opioids varied depending on the measure. One in five participants did not respond subjectively to the 4 mg hydromorphone dose based on their “Drug Effects” rating. Persons who were responsive showed more evidence of drug-dependent effects than did persons who were not responsive on ratings of Bad Effects (p= .03), feeling High (p= .01), Nausea (p= .03), pupil diameter (p< 0.01), and on the circular lights task (p< 0.001). Conclusions: This study provides initial evidence that the experience of opioids may be domain specific. Data suggest potentially clinically meaningful differences exist regarding opioid response patterns, evident following one dose among opioid inexperienced individuals.http://www.sciencedirect.com/science/article/pii/S2772724623000586OpioidHeroinOpioid sensitivityCold pressorOpioid naïvePersonalized medicine |
| spellingShingle | Caitlyn J. Durgin Andrew S. Huhn Cecilia L. Bergeria Patrick H. Finan Claudia M. Campbell Denis G. Antoine Kelly E. Dunn Within subject, double blind, examination of opioid sensitivity in participant-reported, observed, physiologic, and analgesic outcomes Drug and Alcohol Dependence Reports Opioid Heroin Opioid sensitivity Cold pressor Opioid naïve Personalized medicine |
| title | Within subject, double blind, examination of opioid sensitivity in participant-reported, observed, physiologic, and analgesic outcomes |
| title_full | Within subject, double blind, examination of opioid sensitivity in participant-reported, observed, physiologic, and analgesic outcomes |
| title_fullStr | Within subject, double blind, examination of opioid sensitivity in participant-reported, observed, physiologic, and analgesic outcomes |
| title_full_unstemmed | Within subject, double blind, examination of opioid sensitivity in participant-reported, observed, physiologic, and analgesic outcomes |
| title_short | Within subject, double blind, examination of opioid sensitivity in participant-reported, observed, physiologic, and analgesic outcomes |
| title_sort | within subject double blind examination of opioid sensitivity in participant reported observed physiologic and analgesic outcomes |
| topic | Opioid Heroin Opioid sensitivity Cold pressor Opioid naïve Personalized medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2772724623000586 |
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