Angiogenic and pleiotropic effects of VEGF165 and HGF combined gene therapy in a rat model of myocardial infarction.

Angiogenic and pleiotropic effects of VEGF165 and HGF combined gene therapy in a rat model of myocardial infarction.

Since development of plasmid gene therapy for therapeutic angiogenesis by J. Isner this approach was an attractive option for ischemic diseases affecting large cohorts of patients. However, first placebo-controlled clinical trials showed its limited efficacy questioning further advance to practice....

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Bibliographic Details
Main Authors:	Pavel I Makarevich, Konstantin V Dergilev, Zoya I Tsokolaeva, Maria A Boldyreva, Evgeniy K Shevchenko, Evgeny V Gluhanyuk, Julia O Gallinger, Mikhail Yu Menshikov, Yelena V Parfyonova
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2018-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC5963747?pdf=render

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