| Summary: | In this study, Titanium dioxide nanostructures were hydrothermally synthesized at different temperatures 130, 170 and 200 °C. The structural properties and crystallite size of TiO _2 nanostructures were confirmed through XRD analyses. Moreover, the morphologies were confirmed using TEM analyses. These analyses confirmed the formation of single phase TiO _2 nanostructures. The average crystallite size for the TiO _2 nanostructures synthesized at different hydrothermal temperatures of 130, 170, and 200 °C was found to be 11.5 nm, 5.3 nm, and 5 nm, respectively. The impact of changes in these morphologies on the physical characteristics and photokilling activity of cancer cells has been studied. The results showed that the photokilling activity of TiO _2 nanostructures is morphology dependent, with TiO _2 nanowires having the highest activity and nanosheets having the lowest under our experimental conditions.
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