Human ACE2 orthologous peptide sequences show better binding affinity to SARS-CoV-2 RBD domain: Implications for drug design

Human ACE2 orthologous peptide sequences show better binding affinity to SARS-CoV-2 RBD domain: Implications for drug design

Computational methods coupled with experimental validation play a critical role in the identification of novel inhibitory peptides that interact with viral antigenic determinants. The interaction between the receptor binding domain (RBD) of SARS-CoV-2 spike protein and the helical peptide of human a...

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Bibliographic Details
Main Authors: Lena Mahmoudi Azar, Muhammed Miran Öncel, Elif Karaman, Levent Faruk Soysal, Ayesha Fatima, Sy Bing Choi, Alp Ertunga Eyupoglu, Batu Erman, Asif M. Khan, Serdar Uysal
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
ACE2
Surface plasmon resonance (SPR)
Binding affinity
Inhibitory peptides
Biosimilar
Docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023002519

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http://www.sciencedirect.com/science/article/pii/S2001037023002519

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