Repeated intra-articular injections of umbilical cord-derived mesenchymal stem cells for knee osteoarthritis: a phase I, single-arm study
Abstract Introduction Stem cell therapy has emerged as an effective treatment for multiple diseases, and some studies also demonstrate that it may be a promising treatment for osteoarthritis (OA). However, few studies have clarified the safety of repeated intra-articular injection of human umbilical...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-06-01
|
| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-023-06555-y |
| _version_ | 1827923242213441536 |
|---|---|
| author | Yunong Ao Jiangjie Duan Na Xiong Nannan Qian Rui Zhang Liu Yang Shicang Yu Fuyou Wang |
| author_facet | Yunong Ao Jiangjie Duan Na Xiong Nannan Qian Rui Zhang Liu Yang Shicang Yu Fuyou Wang |
| author_sort | Yunong Ao |
| collection | DOAJ |
| description | Abstract Introduction Stem cell therapy has emerged as an effective treatment for multiple diseases, and some studies also demonstrate that it may be a promising treatment for osteoarthritis (OA). However, few studies have clarified the safety of repeated intra-articular injection of human umbilical cord-derived mesenchymal stem cells (UC-MSCs). To promote its application in treating OA, we conducted an open-label trial to investigate the safety of repeated intra-articular injections of UC-MSCs. Methods Fourteen patients with OA (Kellgrene-Lawrence grade 2 or 3) who received repeated intra-articular injections of UC-MSCs were evaluated in three months of follow-up. The primary outcomes were the adverse events, and the second outcomes included visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scores and SF-12 quality of life score. Results A total of 5 of 14 patients (35.7%) experienced transient adverse reactions, which resolved spontaneously. All patients showed some improvement in knee function limitation and pain after receiving stem cell therapy. VAS score 6.0 to 3.5, WOMAC score 26.0 to 8.5, MOCART score 42.0 to 58.0, SF-12 score 39.0 to 46.0. Conclusion Repeated intra-articular injection of UC-MSCs demonstrates safety in treating OA and does not induce serious adverse events. This treatment may transiently improve symptoms in patients with knee OA and may be a potential therapeutic option for OA. |
| first_indexed | 2024-03-13T04:53:57Z |
| format | Article |
| id | doaj.art-d3a646bcbec747649d449cb82b3f18ee |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-03-13T04:53:57Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-d3a646bcbec747649d449cb82b3f18ee2023-06-18T11:03:49ZengBMCBMC Musculoskeletal Disorders1471-24742023-06-012411710.1186/s12891-023-06555-yRepeated intra-articular injections of umbilical cord-derived mesenchymal stem cells for knee osteoarthritis: a phase I, single-arm studyYunong Ao0Jiangjie Duan1Na Xiong2Nannan Qian3Rui Zhang4Liu Yang5Shicang Yu6Fuyou Wang7Center for Joint Surgery, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Stem Cell and Regenerative Medicine, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical UniversityDepartment of Stem Cell and Regenerative Medicine, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical UniversityDepartment of Stem Cell and Regenerative Medicine, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical UniversityDepartment of Stem Cell and Regenerative Medicine, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical UniversityCenter for Joint Surgery, Southwest Hospital, Third Military Medical University (Army Medical University)Department of Stem Cell and Regenerative Medicine, Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical UniversityCenter for Joint Surgery, Southwest Hospital, Third Military Medical University (Army Medical University)Abstract Introduction Stem cell therapy has emerged as an effective treatment for multiple diseases, and some studies also demonstrate that it may be a promising treatment for osteoarthritis (OA). However, few studies have clarified the safety of repeated intra-articular injection of human umbilical cord-derived mesenchymal stem cells (UC-MSCs). To promote its application in treating OA, we conducted an open-label trial to investigate the safety of repeated intra-articular injections of UC-MSCs. Methods Fourteen patients with OA (Kellgrene-Lawrence grade 2 or 3) who received repeated intra-articular injections of UC-MSCs were evaluated in three months of follow-up. The primary outcomes were the adverse events, and the second outcomes included visual analog scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scores and SF-12 quality of life score. Results A total of 5 of 14 patients (35.7%) experienced transient adverse reactions, which resolved spontaneously. All patients showed some improvement in knee function limitation and pain after receiving stem cell therapy. VAS score 6.0 to 3.5, WOMAC score 26.0 to 8.5, MOCART score 42.0 to 58.0, SF-12 score 39.0 to 46.0. Conclusion Repeated intra-articular injection of UC-MSCs demonstrates safety in treating OA and does not induce serious adverse events. This treatment may transiently improve symptoms in patients with knee OA and may be a potential therapeutic option for OA.https://doi.org/10.1186/s12891-023-06555-yOsteoarthritisStem cellKneeCartilage |
| spellingShingle | Yunong Ao Jiangjie Duan Na Xiong Nannan Qian Rui Zhang Liu Yang Shicang Yu Fuyou Wang Repeated intra-articular injections of umbilical cord-derived mesenchymal stem cells for knee osteoarthritis: a phase I, single-arm study BMC Musculoskeletal Disorders Osteoarthritis Stem cell Knee Cartilage |
| title | Repeated intra-articular injections of umbilical cord-derived mesenchymal stem cells for knee osteoarthritis: a phase I, single-arm study |
| title_full | Repeated intra-articular injections of umbilical cord-derived mesenchymal stem cells for knee osteoarthritis: a phase I, single-arm study |
| title_fullStr | Repeated intra-articular injections of umbilical cord-derived mesenchymal stem cells for knee osteoarthritis: a phase I, single-arm study |
| title_full_unstemmed | Repeated intra-articular injections of umbilical cord-derived mesenchymal stem cells for knee osteoarthritis: a phase I, single-arm study |
| title_short | Repeated intra-articular injections of umbilical cord-derived mesenchymal stem cells for knee osteoarthritis: a phase I, single-arm study |
| title_sort | repeated intra articular injections of umbilical cord derived mesenchymal stem cells for knee osteoarthritis a phase i single arm study |
| topic | Osteoarthritis Stem cell Knee Cartilage |
| url | https://doi.org/10.1186/s12891-023-06555-y |
| work_keys_str_mv | AT yunongao repeatedintraarticularinjectionsofumbilicalcordderivedmesenchymalstemcellsforkneeosteoarthritisaphaseisinglearmstudy AT jiangjieduan repeatedintraarticularinjectionsofumbilicalcordderivedmesenchymalstemcellsforkneeosteoarthritisaphaseisinglearmstudy AT naxiong repeatedintraarticularinjectionsofumbilicalcordderivedmesenchymalstemcellsforkneeosteoarthritisaphaseisinglearmstudy AT nannanqian repeatedintraarticularinjectionsofumbilicalcordderivedmesenchymalstemcellsforkneeosteoarthritisaphaseisinglearmstudy AT ruizhang repeatedintraarticularinjectionsofumbilicalcordderivedmesenchymalstemcellsforkneeosteoarthritisaphaseisinglearmstudy AT liuyang repeatedintraarticularinjectionsofumbilicalcordderivedmesenchymalstemcellsforkneeosteoarthritisaphaseisinglearmstudy AT shicangyu repeatedintraarticularinjectionsofumbilicalcordderivedmesenchymalstemcellsforkneeosteoarthritisaphaseisinglearmstudy AT fuyouwang repeatedintraarticularinjectionsofumbilicalcordderivedmesenchymalstemcellsforkneeosteoarthritisaphaseisinglearmstudy |