Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease
Quercetin and curcumin are plant polyphenolic antioxidants with proven pharmacological efficacy. Their use is, however, limited due to low bioavailability and oral administration route. The encapsulation of lipophilic compounds in liposomes enables to increase their bioavailability and to create an...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2021-01-01
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| Series: | BioTechnologia |
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| Online Access: | https://www.termedia.pl/Study-of-antioxidant-activity-of-liposomal-forms-of-quercetin-and-curcumin-in-ischemic-heart-disease,85,42261,1,1.html |
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| author | Daria Pylypenko Tatiana Gorbach Yuriy Krasnopolsky |
| author_facet | Daria Pylypenko Tatiana Gorbach Yuriy Krasnopolsky |
| author_sort | Daria Pylypenko |
| collection | DOAJ |
| description | Quercetin and curcumin are plant polyphenolic antioxidants with proven pharmacological efficacy. Their use is, however, limited due to low bioavailability and oral administration route. The encapsulation of lipophilic compounds in liposomes enables to increase their bioavailability and to create an injectable form. The present study aimed to comparatively investigate the antioxidant activity of a complex liposomal preparation containing two lipophilic antioxidants (quercetin and curcumin) and their monopreparations in liposomal forms. This study was conducted on Wistar line rats with experimental model of ischemic heart disease. Oxidative stress markers such as total antioxidant activity, malondialdehyde, and peroxidized proteins were analyzed in blood serum and cardiac tissue. Ischemic heart disease is accompanied with lipid peroxidation and changes in the activity of the antioxidant system. The obtained results demonstrated the antioxidant activity of monopreparations of curcumin and quercetin and their complex in liposomal forms. Quercetin and curcumin showed different antioxidant activities in terms of oxidative stress markers. The complex of the two antioxidants showed the synergistic effect of their lipophilic compounds in liposomal forms, which led to the normalization of test parameters according to the level of the control sample. |
| first_indexed | 2024-12-17T06:45:11Z |
| format | Article |
| id | doaj.art-d3a7bd6a513b4d5b951f9de17d9c0f9f |
| institution | Directory Open Access Journal |
| issn | 0860-7796 2353-9461 |
| language | English |
| last_indexed | 2024-12-17T06:45:11Z |
| publishDate | 2021-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | BioTechnologia |
| spelling | doaj.art-d3a7bd6a513b4d5b951f9de17d9c0f9f2022-12-21T21:59:46ZengTermedia Publishing HouseBioTechnologia0860-77962353-94612021-01-01101427328210.5114/bta.2020.10042042261Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart diseaseDaria PylypenkoTatiana GorbachYuriy KrasnopolskyQuercetin and curcumin are plant polyphenolic antioxidants with proven pharmacological efficacy. Their use is, however, limited due to low bioavailability and oral administration route. The encapsulation of lipophilic compounds in liposomes enables to increase their bioavailability and to create an injectable form. The present study aimed to comparatively investigate the antioxidant activity of a complex liposomal preparation containing two lipophilic antioxidants (quercetin and curcumin) and their monopreparations in liposomal forms. This study was conducted on Wistar line rats with experimental model of ischemic heart disease. Oxidative stress markers such as total antioxidant activity, malondialdehyde, and peroxidized proteins were analyzed in blood serum and cardiac tissue. Ischemic heart disease is accompanied with lipid peroxidation and changes in the activity of the antioxidant system. The obtained results demonstrated the antioxidant activity of monopreparations of curcumin and quercetin and their complex in liposomal forms. Quercetin and curcumin showed different antioxidant activities in terms of oxidative stress markers. The complex of the two antioxidants showed the synergistic effect of their lipophilic compounds in liposomal forms, which led to the normalization of test parameters according to the level of the control sample.https://www.termedia.pl/Study-of-antioxidant-activity-of-liposomal-forms-of-quercetin-and-curcumin-in-ischemic-heart-disease,85,42261,1,1.htmlcurcumin antioxidant quercetin liposomes oxidative stress markers |
| spellingShingle | Daria Pylypenko Tatiana Gorbach Yuriy Krasnopolsky Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease BioTechnologia curcumin antioxidant quercetin liposomes oxidative stress markers |
| title | Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease |
| title_full | Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease |
| title_fullStr | Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease |
| title_full_unstemmed | Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease |
| title_short | Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease |
| title_sort | study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease |
| topic | curcumin antioxidant quercetin liposomes oxidative stress markers |
| url | https://www.termedia.pl/Study-of-antioxidant-activity-of-liposomal-forms-of-quercetin-and-curcumin-in-ischemic-heart-disease,85,42261,1,1.html |
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