Interplay between chronic widespread pain and lifestyle factors on the risk of type 2 diabetes: longitudinal data from the Norwegian HUNT Study
Introduction Chronic widespread pain (CWP) and diabetes commonly co-occur; however, it is unclear whether CWP infers an additional risk for diabetes among those with known risk factors for type 2 diabetes. We aimed to examine if CWP magnifies the effect of adverse lifestyle factors on the risk of di...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023-10-01
|
| Series: | BMJ Open Diabetes Research & Care |
| Online Access: | https://drc.bmj.com/content/11/5/e003249.full |
| _version_ | 1797628047979970560 |
|---|---|
| author | Bjørn Olav Åsvold Paul Jarle Mork Tom I L Nilsen Anna Marcuzzi Rocio Caceres-Matos Eugenia Gil-Garcia |
| author_facet | Bjørn Olav Åsvold Paul Jarle Mork Tom I L Nilsen Anna Marcuzzi Rocio Caceres-Matos Eugenia Gil-Garcia |
| author_sort | Bjørn Olav Åsvold |
| collection | DOAJ |
| description | Introduction Chronic widespread pain (CWP) and diabetes commonly co-occur; however, it is unclear whether CWP infers an additional risk for diabetes among those with known risk factors for type 2 diabetes. We aimed to examine if CWP magnifies the effect of adverse lifestyle factors on the risk of diabetes.Research design and methods The study comprised data on 25 528 adults in the Norwegian HUNT Study without diabetes at baseline (2006–2008). We calculated adjusted risk ratios (RRs) with 95% CIs for diabetes at follow-up (2017–2019), associated with CWP and body mass index (BMI), physical activity, and insomnia symptoms. The relative excess risk due to interaction (RERI) was calculated to investigate the synergistic effect between CWP and adverse lifestyle factors.Results Compared with the reference group without chronic pain and no adverse lifestyle factors, those with BMI ≥30 kg/m2 with and without CWP had RRs for diabetes of 10.85 (95% CI 7.83 to 15.05) and 8.87 (95% CI 6.49 to 12.12), respectively; those with physical activity <2 hours/week with and without CWP had RRs for diabetes of 2.26 (95% CI 1.78 to 2.88) and 1.54 (95% CI 1.24 to 1.93), respectively; and those with insomnia symptoms with and without CWP had RRs for diabetes of 1.31 (95% CI 1.07 to 1.60) and 1.27 (95% CI 1.04 to 1.56), respectively. There was little evidence of synergistic effect between CWP and BMI ≥30 kg/m2 (RERI=1.66, 95% CI −0.44 to 3.76), low physical activity (RERI=0.37, 95% CI −0.29 to 1.03) or insomnia symptoms (RERI=−0.09, 95% CI −0.51 to 0.34) on the risk of diabetes.Conclusions These findings show no clear interaction between CWP and adverse lifestyle factors on the risk of diabetes. |
| first_indexed | 2024-03-11T10:33:57Z |
| format | Article |
| id | doaj.art-d3a86e59f38443589fd943273e8a1da0 |
| institution | Directory Open Access Journal |
| issn | 2052-4897 |
| language | English |
| last_indexed | 2024-03-11T10:33:57Z |
| publishDate | 2023-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Diabetes Research & Care |
| spelling | doaj.art-d3a86e59f38443589fd943273e8a1da02023-11-14T13:10:08ZengBMJ Publishing GroupBMJ Open Diabetes Research & Care2052-48972023-10-0111510.1136/bmjdrc-2022-003249Interplay between chronic widespread pain and lifestyle factors on the risk of type 2 diabetes: longitudinal data from the Norwegian HUNT StudyBjørn Olav Åsvold0Paul Jarle Mork1Tom I L Nilsen2Anna Marcuzzi3Rocio Caceres-Matos4Eugenia Gil-Garcia5Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, NorwayDepartment of Nursing, Faculty of Nursing, Physiotherapy and Podiatry, University of Seville, Seville, SpainDepartment of Nursing, Faculty of Nursing, Physiotherapy and Podiatry, University of Seville, Seville, SpainIntroduction Chronic widespread pain (CWP) and diabetes commonly co-occur; however, it is unclear whether CWP infers an additional risk for diabetes among those with known risk factors for type 2 diabetes. We aimed to examine if CWP magnifies the effect of adverse lifestyle factors on the risk of diabetes.Research design and methods The study comprised data on 25 528 adults in the Norwegian HUNT Study without diabetes at baseline (2006–2008). We calculated adjusted risk ratios (RRs) with 95% CIs for diabetes at follow-up (2017–2019), associated with CWP and body mass index (BMI), physical activity, and insomnia symptoms. The relative excess risk due to interaction (RERI) was calculated to investigate the synergistic effect between CWP and adverse lifestyle factors.Results Compared with the reference group without chronic pain and no adverse lifestyle factors, those with BMI ≥30 kg/m2 with and without CWP had RRs for diabetes of 10.85 (95% CI 7.83 to 15.05) and 8.87 (95% CI 6.49 to 12.12), respectively; those with physical activity <2 hours/week with and without CWP had RRs for diabetes of 2.26 (95% CI 1.78 to 2.88) and 1.54 (95% CI 1.24 to 1.93), respectively; and those with insomnia symptoms with and without CWP had RRs for diabetes of 1.31 (95% CI 1.07 to 1.60) and 1.27 (95% CI 1.04 to 1.56), respectively. There was little evidence of synergistic effect between CWP and BMI ≥30 kg/m2 (RERI=1.66, 95% CI −0.44 to 3.76), low physical activity (RERI=0.37, 95% CI −0.29 to 1.03) or insomnia symptoms (RERI=−0.09, 95% CI −0.51 to 0.34) on the risk of diabetes.Conclusions These findings show no clear interaction between CWP and adverse lifestyle factors on the risk of diabetes.https://drc.bmj.com/content/11/5/e003249.full |
| spellingShingle | Bjørn Olav Åsvold Paul Jarle Mork Tom I L Nilsen Anna Marcuzzi Rocio Caceres-Matos Eugenia Gil-Garcia Interplay between chronic widespread pain and lifestyle factors on the risk of type 2 diabetes: longitudinal data from the Norwegian HUNT Study BMJ Open Diabetes Research & Care |
| title | Interplay between chronic widespread pain and lifestyle factors on the risk of type 2 diabetes: longitudinal data from the Norwegian HUNT Study |
| title_full | Interplay between chronic widespread pain and lifestyle factors on the risk of type 2 diabetes: longitudinal data from the Norwegian HUNT Study |
| title_fullStr | Interplay between chronic widespread pain and lifestyle factors on the risk of type 2 diabetes: longitudinal data from the Norwegian HUNT Study |
| title_full_unstemmed | Interplay between chronic widespread pain and lifestyle factors on the risk of type 2 diabetes: longitudinal data from the Norwegian HUNT Study |
| title_short | Interplay between chronic widespread pain and lifestyle factors on the risk of type 2 diabetes: longitudinal data from the Norwegian HUNT Study |
| title_sort | interplay between chronic widespread pain and lifestyle factors on the risk of type 2 diabetes longitudinal data from the norwegian hunt study |
| url | https://drc.bmj.com/content/11/5/e003249.full |
| work_keys_str_mv | AT bjørnolavasvold interplaybetweenchronicwidespreadpainandlifestylefactorsontheriskoftype2diabeteslongitudinaldatafromthenorwegianhuntstudy AT pauljarlemork interplaybetweenchronicwidespreadpainandlifestylefactorsontheriskoftype2diabeteslongitudinaldatafromthenorwegianhuntstudy AT tomilnilsen interplaybetweenchronicwidespreadpainandlifestylefactorsontheriskoftype2diabeteslongitudinaldatafromthenorwegianhuntstudy AT annamarcuzzi interplaybetweenchronicwidespreadpainandlifestylefactorsontheriskoftype2diabeteslongitudinaldatafromthenorwegianhuntstudy AT rociocaceresmatos interplaybetweenchronicwidespreadpainandlifestylefactorsontheriskoftype2diabeteslongitudinaldatafromthenorwegianhuntstudy AT eugeniagilgarcia interplaybetweenchronicwidespreadpainandlifestylefactorsontheriskoftype2diabeteslongitudinaldatafromthenorwegianhuntstudy |